Jie, Yan - National University of Singapore

个人简介

Yan Jie is currently a professor at Department of Physics at National University of Singapore, where he first joined as a faculty member in 2005. He is also a principal investigator at NUS Mechanobiology Institute and NUS Centre for BioImaging Sciences. While being trained in theoretical physics, he has since built a strong interest in studying molecular and cell biology using a combination of novel single-molecule biophysical methods and theoretical modeling. In 2015, Yan Jie was awarded American Physical Society (APS) Fellowship. And in 2016, he received the Singapore National Research Foundation (NRF) Investigatorship as well as the Human Frontier Science Program’s Research Grants. Education PhD in experimental biophysics, University of Illinois, Chicago, USA (2005) PhD, Institute of Theoretical Physics of CAS, China (1998)

研究领域

DNA structures, functions, and transitions Nucleoid associated proteins, bacterial chromosomal DNA packaging and gene regulations Mechanical stability of focal adhesion proteins and their roles in mechanosensing by cells Force-dependent conformations and interactions of nucleic acids and proteins Development of single-molecule manipulation and imaging techniques

近期论文

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Application of piconewton forces to individual filopodia reveals mechanosensory role of L-type Ca2+ channels Artem K Efremov, Mingxi Yao, Yuze Sun, Yee Han Tee, Michael P Sheetz, Alexander D Bershadsky, Boris Martinac, Jie Yan Biomaterials 2022 Modulating binding affinity, specificity and configurations by multivalent interactions Yunxin Deng, Artem K Efremov, Jie Yan Biophysical Journal 2022 Effects of size, cooperativity and competitive binding on protein positioning on DNA Leo S McCormack, Artem K Efremov, Jie Yan Biophysical Journal 2021 Mechanical instability of adherens junctions overrides intrinsic quiescence of hair follicle stem cells Ritusree Biswas, Avinanda Banerjee, Sergio Lembo, Zhihai Zhao, Vairavan Lakshmanan, Ryan Lim, Shimin Le, Manando Nakasaki, Vassily Kutyavin, Graham Wright, Dasaradhi Palakodeti, Robert S Ross, Colin Jamora, Valeri Vasioukhin, Yan Jie, Srikala Raghavan Developmental Cell 2021 Mechanical regulation of tension-transmission supramolecular linkages Shimin Le, Miao Yu, Jie Yan Current Opinion in Solid State and Materials Science 2021 Fungal Wound Healing through Instantaneous Protoplasmic Gelation Tu Anh Nguyen, Shimin Le, Michelle Lee, Jing-Song Fan, Daiwen Yang, Jie Yan, Gregory Jedd Current Biology 2020 Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains Miao Yu, Zhihai Zhao, Zibo Chen, Shimin Le, Jie Yan Nature Communications 2020 Implementing Optogenetic Modulation in Mechanotransduction Miao Yu, Shimin Le, Samuel Barnett, Zhenhuan Guo, Xueying Zhong, Pakorn Kanchanawong, Jie Yan Physics Review X 2020 Mechanical regulation of formin-dependent actin polymerization Shimin Le, Miao Yu, Alexander Bershadsky, Jie Yan Seminars in Cell & Developmental Biology 2019 Direct single-molecule quantification reveals unexpectedly high mechanical stability of vinculin—talin/α-catenin linkages Shimin Le, Miao Yu, Jie Yan Science Advances 2019 Single-molecule manipulation quantification of site-specific DNA binding Xiaodan Zhao, Shiwen Guo, Chen Lu, Jin Chen, Shimin Le, Hongxia Fu, Jie Yan Current opinion in chemical biology 2019 Phosphorylation Reduces the Mechanical Stability of the α-Catenin/ β-Catenin Complex Shimin Le, Miao Yu, Jie Yan Angewandte Chemie 2019 Label-free single-molecule quantification of rapamycin-induced FKBP-FRB dimerization for direct control of cellular mechanotransduction Yinan Wang, Samuel Barnett, Shimin Le, Zhenhuan Guo, Xueying Zhong, Pakorn Kanchanawong, Jie Yan Nano Letters 2019 Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion NO Alieva, AK Efremov, S Hu, D Oh, Z Chen, M Natarajan, HT Ong, A Jégou, G Romet-Lemonne, JT Groves, MP Sheetz, J Yan, AD Bershadsky Nature Communications 2019 Force-dependent regulation of KANK1-talin complex at focal adhesions Miao Yu, Shimin Le, York-Christoph Ammon, Benjamin T Goult, Anna Akhmanova, Jie Yan Nano Letters 2019 Mechanical stability of αT-catenin and its activation by force for vinculin binding Si Ming Pang, Shimin Le, Adam V Kwiatkowski, Jie Yan Molecular Biology of the Cell 2019 Force-dependent binding constants Yinan Wang, Jie Yan, Benjamin T Goult Biochemistry 2019 Direct quantification of the translocation activities of Saccharomyces cerevisiae Pif1 helicase Chen Lu, Shimin Le, Jin Chen, Alicia K Byrd, Daniela Rhodes, Kevin D Raney, Jie Yan Nucleic Acid Research 2019 Understanding the catch-bond kinetics of biomolecules on a one-dimensional energy landscape Shiwen Guo, Artem K Efremov, Jie Yan Communications Chemistry 2019 Dystrophin As A Molecular Shock Absorber Shimin Le, Miao Yu, Ladislav Hovan, Zhihai Zhao, James Ervasti, Jie Yan ACS nano 2018