个人简介

学习背景 2009 年 09 月 - 2013 年 06 月，就读于山东大学化学与化工学院，获学士学位。 2013 年 09 月 - 2018 年 06 月，在清华大学生命科学学院攻读，获博士学位。 工作经历 2018 年 08 月 - 2022 年 07 月，在美国普林斯顿大学分子生物学系担任博士后。 2022 年 07 月 - 至今，担任武汉大学药学院教授、博士生导师。

研究领域

1.疾病相关膜蛋白（如离子通道、转运蛋白）功能机制研究 2.膜蛋白翻译后修饰的化学生物学研究 3.靶向重要膜蛋白多肽或小分子药物开发

疾病相关膜蛋白功能机制解析，膜蛋白翻译后修饰的化学生物学研究

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

First Author and Corresponding Author ¨ 1.Shuai Gao#,Xia Yao#, Nieng Yan. “Structure of human Cav2.2 channel blocked by the painkiller ziconotide” (Nature, 2021, 596, 143-147) ¨ 2. Shuai Gao*, Nieng Yan*. “Structural basis of Cav1.1 modulation by dihydropyridine compounds” (Angew. Chem. Int. Ed. Engl. 2020, 60, 3131-3137, Corresponding Author) ¨ 3. Shuai Gao, William C. Valinsky, Nguyen Cam On, Patrick R. Houlihan, Qian Qu, Lei Liu, Xiaojing Pan, David E. Clapham, and Nieng Yan. “Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+ channels in nanodisc” (Proceedings of the National Academy of Sciences. 2020, 117, 14187-14193) ¨ 4. Xia Yao#, Shuai Gao#, Nieng Yan. “Structural basis for pore blockade of human voltage-gated calcium channel Cav1. 3 by motion sickness drug cinnarizine” (Cell Research, 2022) ¨ 5. Yaping Pan#*, Zhenning Ren#,Shuai Gao#*, Jiemin Shen#, Lie Wang, Zhichun Xu, YeYu, Preetham Bachina, Hanzhi Zhang, Xiao Fan, Arthur Laganowsky, Nieng Yan, Ming Zhou*. “Structural basis of ion transport and inhibition in ferroportin” (Nature communications, 2020, 11, 5896, Corresponding Author) ¨ 6. Qian Qu#, Shuai Gao#, Fangming Wu#, Mengge Zhang, Ying Li, Longhua Zhang, Donald Bierer, Changlin Tian, Jishen Zheng, Lei Liu. “Synthesis of disulfide surrogate peptides incorporating large-span surrogate bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy” (Angew. Chem. Int. Ed. Engl. 2020, 59, 6037-6045) ¨ 7. Chenchen Chen#, Shuai Gao#, Huasong Ai, Qian Qu, Changlin Tian, and Yiming Li.“Racemic X-ray structure of L-type calcium channel antagonist Calciseptine prepared by total chemical synthesis” (Science China Chemistry 2018, 61, 702-707) ¨ 8. Shuai Gao#, Man Pan#, Yong Zheng#, Yichao Huang, Qingyun Zheng, Demeng Sun, Lining Lu, Xiaodan Tan, Xianglong Tan, Huan Lan, Jiaxing Wang, Tian Wang, Jiawei Wang, and Lei Liu. “Monomer/Oligomer Quasi-Racemic Protein Crystallography” (J. Am. Chem. Soc. 2016, 138, 14497−14502) ¨ 9. Man Pan#, Shuai Gao#, Yong Zheng#, Xiaodan Tan, Huan Lan, Xianglong Tan, Demeng Sun, Lining Lu, Tian Wang, Qingyun Zheng, Yichao Huang, Jiawei Wang, and Lei Liu. “Quasi-Racemic X‑ray Structures of K27-Linked Ubiquitin Chains Prepared by Total Chemical Synthesis” (J. Am. Chem. Soc. 2016, 138, 7429−7435)