Saeed, Aram - University of East Anglia

个人简介

In 2003, I obtained BSc degree in Pharmacy from the HMU (ranking 1st). In 2010, I have gained PhD in Pharmacy from the University of Nottingham with Cameron Alexander, working on therapeutics polymers. Thereafter, I took up a postdoctoral research position at Network of Excellence for Functional Biomaterials (NUIG), focusing on fabrication of Bioactive Tissue Adhesives for wound healing. Following this time, In 2011 I took up a postdoctoral research position at The EPSRC Centre for Innovative Manufacturing in Regenerative Medicine, working with Kevin Shakesheff and Cameron Alexander. In the latter, i focused on the development of Innovative Biomaterials (3D Matrices for Stem Cells Manufacturing) as multilateral collaborations across Nottingham, Loughborough and Keele Universities. In August 2013, I took up a lecturer role in the School of Pharmacy at the University of East Anglia (UEA) to establish a new research group focusing on designing, fabrication, scale up and validation of Advanced Biomaterials for applications in Drug Delivery System (DDS), Tissue Engineering and Regenerative Medicine (TERM)

研究领域

My background and expertise span across several disciplines including polymer science (Chemistry), pharmaceutical formulation (Pharmacy), and tissue engineering and regenerative medicine (Biology and Medicine), in particular: Design and synthesis of biodegradable, stimuli sensitive (temperature and pH) and functionalised polymers using controlled/living polymerisation techniques (ROP, RAFT and ATRP), Fabrication of colloidal nano- and micro-carriers for targeted and controlled-release delivery of biopharmaceuticals, conventional drugs, biopolymers and therapeutic proteins. Design and Synthesis of three-dimensional (3D) cell culture materials as injectable and implantable cell delivery systems. My current research is focused on development of novel technology platforms for application in Drug Delivery and Tissue Engineering and Regenerative Medicine Acellular 3D biomaterial matrices for use in cellular expansion (In vitro use) Injectable hydrogels as cellular and therapeutic proteins delivery system (In vivo cellular based therapy) 3D printing of complex cellular organisation and tissue-like pattern Design, synthesis and characterisation of polymeric nanoparticulate drug delivery system Targeted therapeutics for cancer treatment with “Smart” nanomaterial with controlled-release features

近期论文

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Hruschka, V., Saeed, A., Slezak, P., Cheikh Al Ghanami, R., Feichtinger, G. A., Alexander, C., Redl, H., Shakesheff, K., Wolbank, S.(2015)Evaluation of a thermoresponsive polycaprolactone scaffold for in vitro three-dimensional stem cell differentiationin Tissue engineering. Part A21.pp. 310-319 Full Text UEA Repository(Article) Hruschka, V., Meinl, A., Saeed, A., Cheikh Al Ghanami, R., Redl, H., Shakesheff, K., Wolbank, S.(2013)Gelatin embedding for the preparation of thermoreversible or delicate scaffolds for histological analysisin Biomedical Materials8.pp. 041001 Full Text UEA Repository(Article) Dong, Y., Hassan, W., Zheng, Y., Saeed, A. O., Cao, H., Tai, H., Pandit, A., Wang, W.(2012)Thermoresponsive hyperbranched copolymer with multi acrylate functionality for in situ cross-linkable hyaluronic acid composite semi-IPN hydrogelin Journal of Materials Science-Materials in Medicine23.pp. 25-35 Full Text UEA Repository(Article) Saeed, A. O., Newland, B., Pandit, A., Wang, W.(2012)The reverse of polymer degradation: in situ crosslinked gel formation through disulfide cleavagein Chemical Communications48.pp. 585-587 Full Text UEA Repository(Article) Dong, Y., Saeed, A. O., Hassan, W., Keigher, C., Zheng, Y., Tai, H., Pandit, A., Wang, W.(2012)“One-step” Preparation of Thiol-Ene Clickable PEG-Based Thermoresponsive Hyperbranched Copolymer for In Situ Crosslinking Hybrid Hydrogelin Macromolecular Rapid Communications33.pp. 120-126 Full Text UEA Repository(Article)