Qi, Sheng - University of East Anglia

个人简介

Sheng obtained her BEng. (Hons) in Industrial Pharmacy in 2001 (China Pharmaceutical University). After completing her PhD in 2004 (Queen’s University of Belfast) in the area of lipid based microparticulate drug delivery systems, Sheng worked as a postdoctoral scientist studying the structure and stability of amorphous polymer-drug dispersions. In 2007 Sheng joined the School of Pharmacy at UEA as a lecturer and was promoted to senior lecturer in 2013. Sheng has worked closely with leading pharmaceutical and excipient companies in the areas of pharmaceutical processing, physicochemical characterisation, and formulation development.

研究领域

Sheng’s current research interests mainly focus on gaining a fundamental understanding of the behaviour of drug-polymer/lipid dispersions in solid (phase behaviour) and liquid (in biological fluids) states, and developing new approaches for stabilising supersaturated drug dispersions. By working with industrial partners as well as cross-discipline collaborators, her group is aiming to contribute to the interdisciplinary research area of enhancing drug absorption via tailoring the physical chemistry of drug formulations. Current research interests include Hot melt extrusion/injection moulding for drug delivery Electrospinning and electrospray-formulation design and processing control Drug-polymer/lipid solubility and miscibility Phase separation behaviour of polymer-drug dispersions Polymer facilitated drug solubilisation in biological fluids Lipid-based liquid crystalline platform for drug delivery Effect of manufacturing processes on stability of amorphous pharmaceuticals

近期论文

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Bouman, J., Belton, P., Venema, P., van der Linden, E., de Vries, R., Qi, S.(2016)Controlled release from zein matrices: Interplay of drug hydrophobicity and pHin Pharmaceutical Research33.pp. 673-685 Full Text UEA Repository(Article) Tipduangta, P., Belton, P., Fabian, L., Wang, L. Y., Tang, H., Eddledton, M., Qi, S.(2016)Electrospun polymer blend nanofibers for tuneable drug delivery: the role of transformative phase separation on controlling the release ratein Molecular Pharmaceutics13.pp. 25-39 Full Text UEA Repository(Article) Qi, S., Craig, D.(2016)Recent developments in micro- and nanofabrication techniques for the preparation of amorphous pharmaceutical dosage formsin Advanced Drug Delivery Reviews100.pp. 67-84 Full Text UEA Repository(Article) Che Rose, L., Bear, J. C., McNaughter, P., Southern, P., Piggott, R. B., Parkin, I. P., Qi, S., Mayes, A.(2016)A SPION-eicosane protective coating for water soluble capsules: Evidence for on-demand drug release triggered by magnetic hyperthermiain Scientific Reports6. Full Text UEA Repository(Article) Yang, X., Ding, Y., Ji, T., Zhao, X., Wang, H., Zhao, X., Zhao, R., Wei, J., Qi, S., Nie, G.(2016)Improvement of the in vitro safety profile and cytoprotective efficacy of amifostine against chemotherapy by PEGylation strategyin Biochemical Pharmacology108.pp. 11-21 Full Text UEA Repository(Article) Che Rose, L., Bear, J. C., Southern, P., McNaughter, P. D., Piggott, R. B., Parkin, I. P., Qi, S., Hills, B. P., Mayes, A. G.(2016)On-demand, magnetic hyperthermia-triggered drug delivery: Optimisation for the GI tractin Journal of Materials Chemistry B4.pp. 1704-1711 Full Text UEA Repository(Article) Alhijjaj, M., Yassin, S., Reading, M., Zeitler, J. A., Belton, P., Qi, S.(2016)Characterization of heterogeneity and spatial distribution of phases in complex solid dispersions by thermal analysis by structural characterization and X-ray micro computed tomographyin Pharmaceutical Research Full Text UEA Repository(Article) Qi, S.(2016)Processing-Induced Disorder in Pharmaceutical Materialspp. 467-491 UEA Repository(Chapter)Dudognon, E., Qi, S.(2016)Disorders in Pharmaceutical Polymerspp. 201-241 UEA Repository(Chapter)Qi, S.(2016)Thermal Analysis of PharmaceuticalsSpringer-Verlag New YorkISBN 978-1-4939-4029-5 UEA Repository(Chapter)Alhijjaj, M., Belton, P., Qi, S.(2016)An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling (FDM) 3D printingin European Journal of Pharmaceutics and Biopharmaceutics108.pp. 111–125 Full Text UEA Repository(Article) Bouman, J., Belton, P., Venema, P., van der Linden, E., de Vries, R., Qi, S.(2015)The development of direct extrusion-injection moulded zein matrices as novel oral controlled drug delivery systemsin Pharmaceutical Research32.pp. 2775-2786 Full Text UEA Repository(Article) Qi, S., Craig, D., Otun, S.(2015)The Use of Quasi-Isothermal Modulated Temperature Differential Scanning Calorimetry for the Characterization of Slow Crystallization Processes in Lipid-Based Solid Self-Emulsifying Systemsin Pharmaceutical Research32.pp. 1316-1324 Full Text UEA Repository(Article) Yang, Z., Nollenberger, K., Albers, J., Craig, D., Qi, S.(2015)Molecular Indicators of Surface and Bulk Instability of Hot Melt Extruded Amorphous Solid Dispersionsin Pharmaceutical Research32.pp. 1210-1228 Full Text UEA Repository(Article) Codoni, D., Belton, P., Qi, S.(2015)Nano-structural analysis of water distribution in hydrated multi-component gels using thermal and NMR relaxometryin Molecular Pharmaceutics12.pp. 2068-2079 Full Text UEA Repository(Article) Ke, P., Qi, S., Sadowski, G., Ouyang, D.(2015)Computational Pharmaceutics: Application of Molecular Modeling in Drug Delivery: Solid dispersion - a pragmatic method to improve the bioavailability of poorly soluble drugsWileyISBN 978-1-118-57399-0 UEA Repository(Book)Tipduangta, P., Takieddin, K., Fabian, L., Belton, P., Qi, S.(2015)A New Low Melting-point Polymorph of Fenofibrate Prepared via Talc Induced Heterogeneous Nucleationin Crystal Growth & Design15.pp. 5011–5020 Full Text UEA Repository(Article) Chan, S., Qi, S., Craig, D. Q.(2015)An Investigation into the Influence of Drug-Polymer Interactions on the Miscibility, Processability and Structure of Polyvinylpyrrolidone-Based Hot Melt Extrusion Formulationsin International Journal of Pharmaceutics496.pp. 95-106 Full Text UEA Repository(Article) Alhijjaj, M., Reading, M., Belton, P., Qi, S.(2015)Thermal Analysis by Structural Characterization (TASC) as a novel method for assessing heterogeneity in complex solid pharmaceutical dosage formsin Analytical Chemistry87.pp. 10848–10855 Full Text UEA Repository(Article) Codoni, D., Cowan, J., Bradley, J., O'Connell, M., McAuley, W., Qi, S.(2015)Disc-shaped polyoxyethylene glycol glycerides gel nanoparticles as novel protein delivery vehiclesin International Journal of Pharmaceutics496.pp. 1015-1025 Full Text UEA Repository(Article)