Al-Jamal, Wafa - University of East Anglia

个人简介

I am always open to discuss possibilities for postdoctoral work and collaborations. Dr Wafa Al-Jamal completed her BSc in Pharmacy (Honour) from Jordan in 2003. She was awarded an Overseas Research Scholarship Award (ORSA) from the University of London to pursue her PhD under the supervision of Professor K Kostarelos, at The School of Pharmacy, University of London (now known as UCL-School of Pharmacy) (2004-2008). Her PhD research focused on developing novel liposome-based structures for combinatory therapeutic and diagnostic purposes. In 2008, Wafa joined UCL School of Pharmacy as a research fellow focusing on live animal imaging and evaluating organ biodistribution of a variety of novel gene delivery vectors (Adenovirus, liposomes, nanoparticles, quantum dots, dendrimers and carbon nanotubes) in vivo. She also acted as the scientific manager of The Nanomedicine Lab’s partnership in FP7 SONODRUGS project (2008-2012). Within SNODRGUS project, Wafa worked in partnership with Philips Research Eindhoven and other 15 European partners on developing novel temperature and pressure-sensitive delivery systems for oncology and cardiac applications. In November 2012, Wafa was appointed at The Institute of Pharmaceutical Science, King’s College London as a senior research associate, focusing on evaluating the behaviour and the efficacy of personalised nanomedicines to fight cancer. Wafa is currently a Prostate Cancer Research Fellow working on developing nanomedicines to target metastatic cancer.

研究领域

Wafa’s main research interests focus on engineering novel nanomaterials for biomedical applications. Her current research, in Cancer Nanomedicine, aims to design smart vectors to deliver a wide range of therapeutic agents and targeting moieties, and to fabricate multifunctional nanoparticles for combinatory therapy and theranostic applications. Her long-term research career is to facilitate the translation of nanoparticle-based therapeutics from the lab to the clinic. Wafa was the GSK Emerging Scientist Award winner for 2015 for her contribution in the field of Cancer Nanomedicine.

近期论文

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Behray, M., Webster, C. A., Pereira, S., Ghosh, P., Krishnamurthy, S., Al-Jamal, W. T., Chao, Y.(2016)Synthesis of Diagnostic Silicon Nanoparticles for Targeted Delivery of Thiourea to Epidermal Growth Factor Receptor-Expressing Cancer Cellsin ACS Applied Materials & Interfaces8.pp. 8908–8917 Full Text UEA Repository(Article) Bai, J., Wang, J. T., Rubio, N., Protti, A., Heidari, H., Elgogary, R., Southern, P., Al-jamal, W. T., Sosabowski, J., Shah, A. M., Bals, S., Pankhurst, Q. A., Al-jamal, K. T.(2016)Triple-Modal Imaging of Magnetically-Targeted Nanocapsules in Solid Tumours In Vivoin Theranostics6.pp. 342-356 Full Text UEA Repository(Article) Bai, J., Wang, J. T., Mei, K., Al-Jamal, W. T., Al-jamal, K. T.(2016)Real-time monitoring of magnetic drug targeting using fibered confocal fluorescence microscopyin Journal of Controlled Release Full Text UEA Repository(Article) Hodgins, N. O., Al-Jamal, W. T., Wang, J. T., Parente-Pereira, A. C., Liu, M., Maher, J., Al-Jamal, K. T.(2016)In vitro potency, in vitro and in vivo efficacy of liposomal alendronate in combination with γδ T cell immunotherapy in micein Journal of Controlled Release241.pp. 229–241 Full Text UEA Repository(Article) Al-Jamal, K. T., Bai, J., Wang, J. T., Protti, A., Southern, P., Bogart, L., Heidari, H., Li, X., Cakebread, A., Asker, D., Al-Jamal, W. T., Shah, A., Bals, S., Sosabowski, J., Pankhurst, Q. A.(2016)Magnetic Drug Targeting: Preclinical in Vivo Studies, Mathematical Modeling, and Extrapolation to Humansin Nano Letters16.pp. 5652-5660 Full Text UEA Repository(Article) Guo, C., Al-Jamal, W. T., Toma, F. M., Bianco, A., Prato, M., Al-Jamal, K. T., Kostarelos, K.(2015)Design of Cationic Multi-Walled Carbon Nanotubes as Efficient siRNA Vectors for Lung Cancer Xenograft Eradicationin Bioconjugate Chemistry26.pp. 1370–1379 Full Text UEA Repository(Article) Pereira, S., Lee, J., Rubio, N., Hassan, H. A. F. M., Suffian, I. B. M., Wang, J. T. W., Klippstein, R., Ballesteros, B., Al-Jamal, W. T., Al-Jamal, K. T.(2015)Cationic Liposome- Multi-Walled Carbon Nanotubes Hybrids for Dual siPLK1 and Doxorubicin Delivery In Vitroin Pharmaceutical Research32.pp. 3293-3308 Full Text UEA Repository(Article) El-Gogary, R. I., Rubio Carrero, N., Wang, J. T., Al-Jamal, W. T., Bourgognon, M., Kafa, H., Naeem, M., Klippstein, R., Abbate, V., Leroux, F., Bals, S., Van Tendeloo, G., Kamel, A. O., Awad, G. A. S., Mortada, N. D., Al-Jamal, K. T.(2014)Polyethylene Glycol Conjugated Polymeric Nanocapsules for Targeted Delivery of Quercetin to Folate-Expressing Cancer Cells In Vitro and In Vivoin ACS Nano8.pp. 1384–1401 Full Text UEA Repository(Article) Roberts, R., Al-Jamal, W., Whelband, M., Thomas, P., Jefferson, M., van den Bossche, J., Powell, P. P., Kostarelos, K., Wileman, T.(2013)Autophagy and formation of tubulovesicular autophagosomes provide a barrier against nonviral gene deliveryin Autophagy9.pp. 667-682 Full Text UEA Repository(Article) Al-Jamal, K. T., Al-Jamal, W. T., Wang, J. T., Rubio, N., Buddle, J., Gathercole, D., Zloh, M., Kostarelos, K., Spheroids, Cellular, Melanoma, Experimental, Mice, Nude, Cell Line, Tumor, Neoplasms, Experimental, Mice, Inbred C57BL(2013)Cationic poly-L-lysine dendrimer complexes doxorubicin and delays tumor growth in vitro and in vivoin ACS Nano7.pp. 1905-17 Full Text UEA Repository(Article) Yilmazer, A., Al-Jamal, W. T., Van den Bossche, J., Kostarelos, K., DNA, Viral, Cell Line, Tumor, Mice, Inbred BALB C(2013)The effect of artificial lipid envelopment of Adenovirus 5 (Ad5) on liver de-targeting and hepatotoxicityin Biomaterials34.pp. 1354-1363 Full Text UEA Repository(Article) Al-Ahmady, Z. S., Al-Jamal, W. T., Bossche, J. V., Bui, T. T., Drake, A. F., Mason, A. J., Kostarelos, K., Cell Line, Tumor, Mice, Inbred C57BL(2012)Lipid-peptide vesicle nanoscale hybrids for triggered drug release by mild hyperthermia in vitro and in vivoin ACS Nano6.pp. 9335-9346 Full Text UEA Repository(Article) Lozano, N., Al-Jamal, W. T., Taruttis, A., Beziere, N., Burton, N. C., Van den Bossche, J., Mazza, M., Herzog, E., Ntziachristos, V., Kostarelos, K.(2012)Liposome-gold nanorod hybrids for high-resolution visualization deep in tissuesin Journal of the American Chemical Society134.pp. 13256-13258 Full Text UEA Repository(Article) Al-Jamal, K. T., Nunes, A., Methven, L., Ali-Boucetta, H., Li, S., Toma, F. M., Herrero, M. A., Al-Jamal, W. T., ten Eikelder, H. M. M., Foster, J., Mather, S., Prato, M., Bianco, A., Kostarelos, K., Microscopy, Electron, Models, Molecular, Nanotubes, Carbon(2012)Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profilein Angewandte Chemie International Edition51.pp. 6389-6393 Full Text UEA Repository(Article) Al-Jamal, W. T., Al-Ahmady, Z. S., Kostarelos, K., Hyperthermia, Induced, Mice, Inbred C57BL, Cell Line, Tumor, Calorimetry, Differential Scanning(2012)Pharmacokinetics & tissue distribution of temperature-sensitive liposomal doxorubicin in tumor-bearing mice triggered with mild hyperthermiain Biomaterials33.pp. 4608-4617 Full Text UEA Repository(Article) Al-jamal, K. T., Al-jamal, W. T., Kostarelos, K., Turton, J. A., Florence, A. T.(2012)Anti-angiogenic poly-L-lysine dendrimer binds heparin and neutralizes its activityin Results in Pharma Sciences2.pp. 9-15 Full Text UEA Repository(Article) Al-Jamal, W. T., Kostarelos, K., Cell Line, Tumor(2011)Liposomes: from a clinically established drug delivery system to a nanoparticle platform for theranostic nanomedicinein Accounts of Chemical Research44.pp. 1094-1104 Full Text UEA Repository(Article) Tian, B., Al-Jamal, W. T., Al-Jamal, K. T., Kostarelos, K., Spectrometry, Fluorescence, Antibiotics, Antineoplastic, Microscopy, Atomic Force(2011)Doxorubicin-loaded lipid-quantum dot hybrids: surface topography and release propertiesin International Journal of Pharmaceutics416.pp. 443-447 Full Text UEA Repository(Article) Van den Bossche, J., Al-Jamal, W. T., Yilmazer, A., Bizzarri, E., Tian, B., Kostarelos, K., Mice, Nude, Receptors, Virus(2011)Intracellular trafficking and gene expression of pH-sensitive, artificially enveloped adenoviruses in vitro and in vivoin Biomaterials32.pp. 3085-3093 Full Text UEA Repository(Article) Van den Bossche, J., Al-Jamal, W. T., Tian, B., Nunes, A., Fabbro, C., Bianco, A., Prato, M., Kostarelos, K., Microscopy, Electron, Electrophoresis, Polyacrylamide Gel, Aptamers, Nucleotide, Cell Line, Tumor, Receptors, Cell Surface, Nanotubes, Carbon(2010)Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubesin Chemical communications (Cambridge, England)46.pp. 7379-7381 Full Text UEA Repository(Article)