Hamilton, Christopher - University of East Anglia

个人简介

Chris Hamilton graduated from the University of Liverpool (1994) and got his PhD (1997) from the University of Exeter working with Prof. Stan Roberts on the synthesis of biologically stable nor-carbovir triphosphate analogues as inhibitors of HIV reverse transcriptase. This was followed by postdoctoral appointments with Prof David Gani working on ‘protein phosphatase assay development’ (St Andrews, 1998) and Dr Ian Eggleston/Prof Alan Fairlamb ‘synthesis of lunaria alkaloids & mechanistic studies as trypanothione reductase inhibitors’, (Dundee, 1999-2000). He then worked at UEA with Prof. Rob Field, first as a postdoctoral researcher (Studying Bordetella pertussis lipopolysaccharide biosynthesis, 2001) and then as a fixed term lecturer (2002). Shortly after receiving a Wellcome Trust SHOWCASE award, he took up post as Lecturer in Organic Chemistry at Queen’s University Belfast in late-2003. He returned to UEA (late 2007). His research interests reside at the Chemistry/Biology interface. This is exemplified by the cross section of research group members, which includes researchers with expertise in synthetic chemistry, biochemistry, microbiology and plant biology.

研究领域

Chemical and biochemical functions of low molecular weight thiols in Gram positive bacteria. Redox mechanisms of bioactive organosulfur metabolites from garlic Mechanistic enzymology Our research programs embrace a diverse range of disciplines such as Synthetic Chemistry, Biotransformations, Enzymology, Biochemistry and Molecular/Microbiology. This facilitates the design, synthesis and application of novel chemical tools to address complex biological/medicinal challenges. Traversing these disciplinary boundaries provides a stimulating interdisciplinary research culture, and excellent research training/experience, across the full spectrum of the chemical/life sciences interface from the extremes of Synthetic Organic Chemistry to Cell Biology and beyond.

近期论文

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Kay, K. L., Hamilton, C. J., Le Brun, N. E.(2016)Mass spectrometry ofin Metallomics8.pp. 709-719 Full Text UEA Repository(Article) Sharma, S. V., Van Laer, K., Messens, J., Hamilton, C. J.(2016)Thiol redox and pKa properties of mycothiol, the predomiant low molecular weight thiol cofactor in the Actinomycetesin ChemBioChem17.pp. 1689–1692 Full Text(Letter)Crack, J., Munnoch, J. T., Dodd, E., Knowles, F., Al-Bassam, M., Kamali, S., Holland, A., Cramer, S., Hamilton, C., Johnson, M., Thomson, A., Hutchings, M., Le Brun, N.(2015)NsrR from Streptomyces coelicolor Is a Nitric Oxide-sensing [4Fe-4S] Cluster Protein with a Specialized Regulatory Functionin The Journal of Biological Chemistry290.pp. 12689-12704 Full Text UEA Repository(Article) O'neill, E. C., Trick, M., Hill, L., Rejzek, M., Dusi, R. G., Hamilton, C. J., Zimba, P. V., Henrissat, B., Field, R. A.(2015)The transcriptome of Euglena gracilis reveals unexpected metabolic capabilities for carbohydrate and natural product biochemistryin Molecular BioSystems11.pp. 2808-2820 Full Text UEA Repository(Article) Posada, A. C., Kolar, S. L., Dusi, R. G., Francois, P., Roberts, A. A., Hamilton, C. J., Liu, G. Y., Cheung, A.(2014)The Importance of Bacillithiol in the Oxidative Stress Response of Staphylococcus aureusin Infection and Immunity82.pp. 316-332 Full Text UEA Repository(Article) Luan, H., Meng, N., Fu, J., Chen, X., Xu, X., Feng, Q., Jiang, H., Dai, J., Yuan, X., Lu, Y., Roberts, A. A., Luo, X., Chen, M., Xu, S., Li, J., Hamilton, C., Fang, C., Wang, J., Chuang, E. Y. (ed.)(2014)Genome-Wide Transcriptome and Antioxidant Analyses on Gamma-Irradiated Phases of Deinococcus radiodurans R1in PLoS ONE9. Full Text UEA Repository(Article) Gaballa, A., Chi, B. K., Roberts, A. A., Becher, D., Hamilton, C., Antelmann, H., Helmann, J. D.(2014)Redox Regulation in Bacillus subtilis : The Bacilliredoxins BrxA(YphP) and BrxB(YqiW) Function in De-bacillithiolation of S -Bacillithiolated OhrR and MetEin Antioxidants & Redox Signaling21.pp. 357-367 Full Text UEA Repository(Article) Chandrangsu, P., Dusi, R., Hamilton, C. J., Helmann, J. D., Hamilton, C.(2014)Methylglyoxal resistance in Bacillus subtilis : contributions of bacillithiol-dependent and independent pathways: Methylglyoxal resistance in Bacillus subtilisin Molecular Microbiology91.pp. 706-715 Full Text UEA Repository(Article) Fang, Z., Roberts, A., Weidman, K., Sharma, S., Claiborne, A., Hamilton, C., Dos Santos, P. C.(2013)Cross functionalities of Bacillus deacetylases involved in bacillithial biosynthesis and bacillitiol-S-conjugate detoxification pathwaysin Biochemistry Journal454.pp. 239-247 Full Text UEA Repository(Article) Sharma, S. V., Arbach, M., Roberts, A. A., Macdonald, C. J., Groom, M., Hamilton, C. J.(2013)Biophysical Features of Bacillithiol, the Glutathione Surrogate of Bacillus subtilis and other Firmicutesin ChemBioChem14.pp. 2160-2168 Full Text UEA Repository(Article) Gaballa, A., Antelmann, H., Hamilton, C. J., Helmann, J. D.(2013)Regulation of Bacillus subtilis bacillithiol biosynthesis operons by Spxin Microbiology159.pp. 2025-2035 Full Text UEA Repository(Article) Iqbal, A., Chibli, H., Hamilton, C.(2013)Stability of aminooxy glycosides to glycosidase catalysed hydrolysisin Carbohydrate Research377.pp. 1-3 Full Text UEA Repository(Article) Rajkarnikar, A., Strankman, A., Duran, S., Vargas, D., Roberts, A. A., Barretto, K., Upton, H., Hamilton, C. J., Rawat, M.(2013)Analysis of mutants disrupted in bacillithiol metabolism in Staphylococcus aureusin Biochemical and Biophysical Research Communications436.pp. 128-133 Full Text UEA Repository(Article) Roberts, A., Sharma, S., Strankman, A., Duran, S., Rawat, M., Hamilton, C., Hamilton, C.(2013)Mechanistic studies of FosB: a divalent-metal-dependent bacillithiol-S-transferase that mediates fosfomycin resistance in Staphylococcus aureusin Biochemical Journal451.pp. 69-79 Full Text UEA Repository(Article) Pöther, D., Gierok, P., Harms, M., Mostertz, J., Hochgräfe, F., Antelmann, H., Hamilton, C. J., Borovok, I., Lalk, M., Aharonowitz, Y., Hecker, M., Hamilton, C.(2013)Distribution and infection-related functions of bacillithiol in Staphylococcus aureusin International Journal of Medical Microbiology303.pp. 114-123 Full Text UEA Repository(Article) Chi, B. K., Roberts, A. A., Huyen, T. T. T., Bäsell, K., Becher, D., Albrecht, D., Hamilton, C. J., Antelmann, H., Hamilton, C.(2013)S-Bacillithiolation Protects Conserved and Essential Proteins Against Hypochlorite Stress in Firmicutes Bacteriain Antioxidants & Redox Signaling18.pp. 1273-1295 Full Text UEA Repository(Article) Antelmann, H., Hamilton, C.(2012)Bacterial mechanisms of reversible protein S-thiolation: structural and mechanistic insights into mycoredoxinsin Molecular Microbiology86.pp. 759-764 Full Text UEA Repository(Article) Banoz-Sanz, J., Sanz-Aparicio, J., Whitfield, H., Hamilton, C., Brearley, C., Gonzalez, B.(2012)Conformational changes in Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase Upon Substrate Binding: The Role of N-Terminal Lobe and Enantiomeric Substrate Preferencein The Journal of Biological Chemistry287.pp. 29237-29249 UEA Repository(Article) Banos-sanz, J. I., Sanz-aparicio, J., Whitfield, H., Hamilton, C., Brearley, C. A., Gonzalez, B.(2012)Conformational Changes in Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase upon Substrate Binding: Role of N-terminal lobe and enantiomeric substrate preferencein Journal of Biological Chemistry287.pp. 29237-29249 Full Text UEA Repository(Article) Sharma, S., Jothivasan, V., Newton, G., Upton, H., Wakabayashi, J., Kane, M., Roberts, A., Rawat, M., La Clair, J., Hamilton, C.(2011)Chemical and chemoenzymatic syntheses of bacillithiol, a unique low molecular weight thiol amongst low G + C Gram positive bacteriain Angewandte Chemie International Edition50.pp. 7101-7104 Full Text UEA Repository(Article)