Sachdeva, Amit - University of East Anglia

个人简介

Amit Sachdeva is a lecturer in Bio-organic Chemistry at UEA and his research interests are in the area of Chemical Biology and Synthetic Biology. Amit completed his PhD from the University of Illinois at Urbana-Champaign, where he was involved in identification of DNA-based enzymes with potential for biomedical and diagnostic applications. He then moved to Cambridge for postdoctoral work at the MRC Laboratory of Molecular Biology. Here, he was involved in developing methods to enable synthesis of proteins containing multiple non-natural amino acids in live cells.

研究领域

Nature elegantly orchestrates complex chemical and physical transformations to accomplish functions as diverse as transmitting information across generations to harvesting energy from sunlight. These natural processes are achieved by the limited chemical functionality available to biology. Expanding the repertoire of chemical functional groups available to biology can lead to development of new biological systems with potential applications in biotechnology, biofuels and medicine. The focus of our current research work is in developing methods to enable genetic incorporation of structurally diverse non-natural amino acids into proteins and also, to employ these non-natural amino acids to create novel proteins that can be used in medicine. We currently have one fully funded PhD position available. Please follow the link to apply for this position. Please email me directly at a.sachdeva@uea.ac.uk for alternative sources of funding or to discuss potential projects. If you are interested in a postdoctoral position in our laboratory, please email me directly. We are very interested in potential postdocs with a strong background in cell biology, synthetic biology or chemical biology. Applicants are encouraged to look for funding sources, including Wellcome Trust Postdoctoral Fellowship, Marie Curie Fellowships, Newton Fellowship.

近期论文

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Rogerson, D., Sachdeva, A., Wang, K., Haq, T., Kazlauskaite, A., Hancock, S., Hugenin-Dezot, N., Muqit, M., Fry, A., Bayliss, R., Chin, J.(2015)Efficient genetic encoding of phosphoserine and its non-hydrolyzable analogin Nature Chemical Biology11.pp. 496–503 Full Text UEA Repository(Article) Brandsen, B. M., Velez, T. E., Sachdeva, A., Ibrahim, N. A., Silverman, S. K.(2014)DNA-Catalyzed Lysine Side Chain Modificationin Angewandte Chemie International Edition53.pp. 9045-9050 Full Text UEA Repository(Article) Elliott, T. S., Townsley, F. M., Bianco, A., Ernst, R. J., Sachdeva, A., Elsässer, S. J., Davis, L., Lang, K., Pisa, R., Greiss, S., Lilley, K. S., Chin, J. W.(2014)Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animalin Nature Biotechnology32.pp. 465-472 Full Text UEA Repository(Article) Wang, K., Sachdeva, A., Cox, D. J., Wilf, N. W., Lang, K., Wallace, S., Mehl, R. A., Chin, J. W.(2014)Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRETin Nature Chemistry6.pp. 393-403 Full Text UEA Repository(Article) Sachdeva, A., Wang, K., Elliott, T., Chin, J. W.(2014)Concerted, Rapid, Quantitative, and Site-Specific Dual Labeling of Proteinsin Journal of the American Chemical Society136.pp. 7785-7788 Full Text UEA Repository(Article) Walsh, S. M., Sachdeva, A., Silverman, S. K.(2013)DNA Catalysts with Tyrosine Kinase Activityin Journal of the American Chemical Society135.pp. 14928-14931 Full Text UEA Repository(Article) Sachdeva, A., Silverman, S. K.(2012)DNA-catalyzed reactivity of a phosphoramidate functional group and formation of an unusual pyrophosphoramidate linkagein Organic & Biomolecular Chemistry10.pp. 122-125 Full Text UEA Repository(Article) Sachdeva, A., Chandra, M., Chandrasekar, J., Silverman, S. K.(2012)Covalent Tagging of Phosphorylated Peptides by Phosphate-Specific Deoxyribozymesin ChemBioChem13.pp. 654-657 Full Text UEA Repository(Article) Sachdeva, A., Silverman, S. K.(2010)DNA-catalyzed serine side chain reactivity and selectivityin Chemical Communications46.pp. 2215 Full Text UEA Repository(Article) Chandra, M., Sachdeva, A., Silverman, S. K.(2009)DNA-catalyzed sequence-specific hydrolysis of DNAin Nature Chemical Biology5.pp. 718-720 Full Text UEA Repository(Article) Kaiser, M., Nambissan, P., Banerjee, M., Sachdeva, A., Pujari, P.(2007)Positron lifetime studies and coincidence Doppler broadening spectroscopy of Al-6Mg-xSc (x= 0 to 0.6 wt.%) alloyin Journal of Materials Science42. Full Text UEA Repository(Article) Sudarshan, K., Rath, S., Patri, M., Sachdeva, A., Pujari, P.(2007)Positron annihilation spectroscopic studies of fluorinated ethylene propylene copolymer-g-polystyrenein Polymer48.pp. 6434-6438 Full Text UEA Repository(Article) Sachdeva, A., Sodaye, S., Pandey, A. K., Goswami, A.(2006)Formation of Silver Nanoparticles in Poly(perfluorosulfonic) Acid Membranein Analytical Chemistry78.pp. 7169-7174 Full Text UEA Repository(Article) Dutta, D., Sachdeva, A., Pujari, P.(2006)Positron annihilation studies on the phase transition of benzene and reactivity of nitrobenzene in confined framework of ZSM-5 zeolitein Chemical Physics Letters432.pp. 116-121 Full Text UEA Repository(Article) Sachdeva, A., Chavan, S., Goswami, A., Tyagi, A., Pujari, P.(2005)Positron annihilation spectroscopic studies on Nd-doped ceriain Journal of Solid State Chemistry178.pp. 2062-2066 Full Text UEA Repository(Article) Sachdeva, A., Sudarshan, K., Pujari, P. K., Goswami, A., Sreejith, K., George, V. C., Pillai, C. G. S., Dua, A. K.(2004)Identification of nitrogen decorated vacancies in CVD diamond films using positron annihilation coincidence Doppler broadening spectroscopyin Diamond and Related Materials13.pp. 1719-1724 Full Text UEA Repository(Article) Dutt, G. B., Sachdeva, A.(2003)Temperature-dependent rotational relaxation in a viscous alkane: Interplay of shape factor and boundary condition on molecular rotationin The Journal of Chemical Physics118. Full Text UEA Repository(Article)