Mayes, Andrew - University of East Anglia

个人简介

I began my career as a biochemist and did a PhD in physical biochemistry at the interface between biochemistry and chemical engineering (both at the University of Bath). I then spent two years at the Chemical Centre in Lund, Sweden as a Royal Society Travelling Fellow, working in the field of molecular imprinting with Prof. Klaus Mosbach, one of the key innovators in the field. Following that I returned to the UK and worked at the Institute of Biotechnology in Cambridge, working for 4 years with Prof. Chris Lowe on the development of mass producible chemical sensors based on optical holograms. I was then appointed to a lectureship in chemistry at UEA in 1999 and have been here ever since, being promoted to Senior lecturer in 2006. My research revolves around designing custom polymers and materials and applying them to address problems in chemical sensor development, separation science and drug delivery. Further details appear on my research pages. I am passionate about science communication and in particular outreach and engagement work with schools. I have run an annual heat of the RSC Schools’ Analyst Competition at UEA for the past decade and organised the national final of the event in 2007. I have also done many polymers, materials, spectroscopy and forensic schools events (both at UEA and in schools) to a variety of different age groups from 5 to 18. I am Science Link Governor at my local high school (Pakefield High School, Lowestoft) and also serve on the committee of the RSC Analytical Division East Anglia Region, which organises a variety of technical and social meetings for the analytical community.

研究领域

The Mayes group works at the interface between smart polymers and nanostructured materials to develop new approaches to chemical analysis and targeted drug delivery. A particular strength of the group is the application of a wide range of analytical techniques to the characterisation of these often complex materials, to understand their structures and properties better. A number of projects are being pursued involving designing “smart” polymers (e.g. analyte-selective hydrogels or molecularly imprinted polymers - MIPs) and grafting them onto nanoparticles to provide new assay configurations or new approaches for drug delivery. In particular we are interested in grafting thin films of MIPs onto organic or inorganic cores to develop robust and inexpensive “plastic antibodies” that might replace biological antibodies in assays and (bio)chemical sensors. We also work on developing complex hierarchically-structured MIPs (using holograms, nanoporous templates or colloidal crystal arrays for example) that can be used in optical sensing devices (collaboration with Prof. K. Haupt, UTC Compiegne, France). In the area of drug delivery we are especially interested in thermosensitive polymer materials that respond to small changes in temperature by undergoing changes to their properties (e.g. collapsing hydrogels or liquids that turn into gels). Combining these materials with the ability to heat objects using magnetic hyperthermia – a process involving exposing materials containing superparamagnetic nanoparticles to radio-frequency electromagnetic fields - allows us to create novel composite nanomaterials whose properties can be tuned and switched on demand. We have recently developed a model colonic drug delivery system exploiting this process and now wish to develop these concepts into new materials and new areas of drug delivery. In the separations area, we are interested in high temperature chromatography and, in particular, in developing robust new nanoporous polymeric stationary phases that are stable in superheated water and able to separate typical uncharged organic analytes (the kinds of molecules usually separated by reversed phase chromatography) in pure water. Working in superheated water offers some exciting opportunities for separations, but also causes a number of problems that need to be overcome to exploit this interesting area effectively. We also pursue a variety of activities related to applying modern spectroscopic and sensing techniques to problems in marine science, particularly marine sediments, in association with Cefas. We are currently developing visual colourimetric sensors for sediment pH and redox potential and are becoming increasingly interested in marine microplastics and their identification and quantitation. Over the last few years, the group has become involved with applying neutron scattering methods to various problems involving polymers and nanoparticles, including co-nonsolvency phenomena in polymer solutions and the adsorption of ligands, polymers and protein coronas on the surfaces of a variety of nanoparticles. This work has been done in collaboration with Dr. U. Jayasooriya and Dr. F. Baldelli Bombelli. In total we have been granted 24 days of beamtime at ISIS, RAL and ILL Grenoble to pursue this work, through a series of proposals.

近期论文

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Bear, J. C., Hollingsworth, N., Mcnaughter, P. D., Mayes, A. G., Ward, M. B., Nann, T., Hogarth, G., Parkin, I. P.(2014)Copper-Doped CdSe/ZnS Quantum Dots: Controllable Photoactivated Copper(I) Cation Storage and Release Vectors for Catalysisin Angewandte Chemie International Edition53.pp. 1598-1601 Full Text UEA Repository(Article) Fuchs, Y., Kunath, S., Soppera, O., Haupt, K., Mayes, A. G.(2014)Molecularly Imprinted Silver-Halide Reflection Holograms for Label-Free Opto-Chemical Sensingin Advanced Functional Materials24.pp. 688-694 Full Text UEA Repository(Article) Fuchs, Y., Soppera, O., Mayes, A. G., Haupt, K.(2013)Holographic Molecularly Imprinted Polymers for Label-Free Chemical Sensingin Advanced Materials25.pp. 566-570 Full Text UEA Repository(Article) Mcnaughter, P., Bear, J., Steytler, D., Mayes, A., Nann, T.(2011)A Thin Silica-Polymer Shell for Functionalizing Colloidal Inorganic Nanoparticlesin Angewandte Chemie International Edition50.pp. 10384-10387 Full Text UEA Repository(Article)