MacMillan, Fraser - University of East Anglia

个人简介

Fraser obtained a BSc in Chemistry from the University of Sheffield in 1987 and a Dr. rer. nat. from the Department of Chemistry at the Free University of Berlin (Germany) in 1993. He pursued post-doctoral research at the Technical University Berlin (Germany) (1993-1995), the Commissariat de l’Energie Atomique, Saclay, France (1995-1998) and the Johann Wolfgang Goethe-University Frankfurt (Germany) (1998-2006). Fraser is currently a Reader in the School of Chemistry at the University of East Anglia, Norwich where he joined the faculty in 2007. To coincide with his appointment Fraser has won a Royal Society Wolfson Research Merit Award. He leads biological EPR research in the Henry Welcome Laboratory. His present research aims to elucidate structure / function / dynamics relationships in biomacromolecules and macromolecular complexes. Particular emphasis being on the application, and expansion, of electron paramagnetic resonance methods to study membrane proteins.

研究领域

All Aspects of Paramagnetic Resonance Spectroscopy (EPR, ESR) including Multi-Frequency (S-, X-, Q-, W-bands) EPR and Pulsed EPR (ENDOR, PELDOR, ESEEM, HYSCORE) Spectroscopy Membrane and metalloproteins including photosynthetic and respiratory proteins Structure/function/dynamics relationships in biomacromolecules Electron transfer and (ABC-)transporter proteins

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Mullen, A., Hall, J., Diegel, J., Hassan, I., Fey, A., MacMillan, F.(2016)Membrane transporters studied by EPR spectroscopy: structure determination and elucidation of functional dynamicsin Biochemical Society Transactions44.pp. 905-915 Full Text UEA Repository(Article) Deplazes, E., Begg, S. L., Van Wonderen, J. H., Campbell, R., Kobe, B., Paton, J. C., MacMillan, F., McDevitt, C. A., O'Mara, M. L.(2015)Characterizing the conformational dynamics of metal-free PsaA using molecular dynamics simulations and electron paramagnetic resonance spectroscopyin Biophysical Chemistry207.pp. 51-60 Full Text UEA Repository(Article) Stockner, T., Mullen, A., Macmillan, F.(2015)Investigating the dynamic nature of the ABC transporters: ABCB1 and MsbA as examples for the potential synergies of MD theory and EPR applicationsin Biochemical Society Transactions43.pp. 1023-1032 Full Text UEA Repository(Article) Van Wonderen, J., McMahon, R., OMara, M., McDevitt, C., Thomson, A., Kerr, I., MacMillan, F., Callaghan, R.(2014)The central cavity of ABCB1 undergoes alternating access during ATP hydrolysisin FEBS Journal281.pp. 2190-2201 Full Text UEA Repository(Article) Van Wonderen, J., Kostrz, D., Dennison, C., MacMillan, F.(2013)Refined distances between paramagnetic centers of a multi-copper nitrite reductase determined by pulsed EPR (iDEER) spectroscopyin Angewandte Chemie International Edition52.pp. 1990-1993 Full Text UEA Repository(Article) Riikonen, J., Salomäki, M., Van Wonderen, J., Kemell, M., Xu, W., Korhonen, O., Ritala, M., MacMillan, F., Salonen, J., Lehto, V.(2012)Surface chemistry, reactivity, and pore structure of porous silicon oxidized by various methodsin Langmuir28.pp. 10573-10583 Full Text UEA Repository(Article) Hilbers, F., van Wonderen, J., Lorenzen, W., Bode, H. B., MacMillan, F., Ludwig, B., Michel, H.(2012)The catalase activity of the aa(3) cytochrome c oxidase from Paracoccus denitrificansin Biochimica et Biophysica Acta - Bioenergetics1817.pp. S108-S108 Full Text UEA Repository(Article) von der Hocht, I., Van Wonderen, J., Hilbers, F., Angerer, H., Macmillan, F., Michel, H.(2011)Interconversions of P and F intermediates of cytochrome c oxidase from Paracoccus denitrificansin Proceedings of the National Academy of Sciences of the United States of America (PNAS)108.pp. 3964-3969 Full Text UEA Repository(Article) Macmillan, F., Kacprzak, S., Hellwig, P., Grimaldi, S., Michel, H., Kaupp, M.(2011)Elucidating mechanisms in haem copper oxidases: The high-affinity Q(H) binding site in quinol oxidase as studied by DONUT-HYSCORE spectroscopy and density functional theoryin Faraday Discussions148.pp. 315-344 Full Text UEA Repository(Article) Macmillan, F., Hunte, C.(2010)Quinone binding and catalysisin Biochimica et Biophysica Acta - Bioenergetics1797.pp. 1841 Full Text UEA Repository(Article) Macmillan, F., Lange, C., Bawn, M., Hunte, C.(2010)Resolving the EPR Spectra in the Cytochrome bc (1) Complex from Saccharomyces cerevisiaein Applied Magnetic Resonance37.pp. 305-316 Full Text UEA Repository(Article) MacMillan, F., Cammack, R.(2010)Electron Magnetic Resonance of Iron-Sulfur Proteins in Electron-Transfer Chains: Resolving ComplexitySpringer-Verlag Berlin Heidelbergpp. 11-44ISBN 978-1-4419-1138-4 Full Text(Chapter (peer-reviewed))Macmillan, F., Van Wonderen, J., Cheesman, M., Van Der Hocht, I., Angerer, H., Gennis, R., Michel, H.(2010)Using EPR up close and from afar: Elucidating mechanisms in haem copper oxidasesin Biochimica et Biophysica Acta - Bioenergetics1797.pp. 97 Full Text UEA Repository(Article) von der Hocht, I., van Wonderen, J. H., MacMillan, F., Michel, H.(2010)Interconversions of P and F intermediates of cytochrome c oxidase from Paracoccus denitrificansin Biochimica et Biophysica Acta - Bioenergetics1797.pp. 102-102 Full Text UEA Repository(Article) Michel, H., Angerer, H., Koepke, J., Macmillan, F.(2008)P/19 Evidence for the presence of a peroxide in the binuclear site of oxidized cytochrome c oxidase: The new catalytic cyclein Biochimica et Biophysica Acta - Bioenergetics1777.pp. S6-S7 Full Text UEA Repository(Article) Teutloff, C., White, G., Gennis, R. B., Thomson, A. J., Macmillan, F.(2008)S11.8 The coupling of electron and proton transfer in haem copper oxidases as studied by peldor spectroscopyin Biochimica et Biophysica Acta - Bioenergetics1777.pp. S67 Full Text UEA Repository(Article) Macmillan, F., Angerer, H., Kaupp, M., Teutloff, C., Michel, H.(2008)S11/7 The mechanism of haem copper oxidases studied by EPR spectroscopyin Biochimica et Biophysica Acta - Bioenergetics1777.pp. S66-S67 Full Text UEA Repository(Article) Angerer, H., Macmillan, F., Michel, H.(2008)S11.38 The reversibility of P → F state transition in cytochrome c oxidase from Paracoccus denitrificansin Biochimica et Biophysica Acta - Bioenergetics1777.pp. S74 Full Text UEA Repository(Article) Barthelme, D., Scheele, U., Dinkelaker, S., Janoschka, A., Macmillan, F., Albers, S. V., Driessen, A. J. M., Stagni, M. S., Bill, E., Meyer-Klaucke, W., Schunemann, V., Tampe, R.(2007)Structural organization of essential iron-sulfur clusters in the evolutionarily highly conserved ATP-binding cassette protein ABCE1in Journal of Biological Chemistry282.pp. 14598-14607 Full Text UEA Repository(Article) Wenz, T., Covian, R., Hellwig, P., Macmillan, F., Meunier, B., Trumpower, B. L., Hunte, C.(2007)Mutational analysis of cytochrome b at the ubiquinol oxidation site of yeast complex IIIin Journal of Biological Chemistry282.pp. 3977-3988 Full Text UEA Repository(Article)