Wormstone, Michael - University of East Anglia - School of Biological Sciences

个人简介

Senior Lecturer, University of East Anglia (2008-present) The Humane Research Trust Lecturer, University of East Anglia (2002-2008) Senior Research Associate - University of East Anglia (1997-2002) PhD - University of East Anglia (1997) BSc - Pharmacology, University of Portsmouth (1993)

研究领域

I am a biomedical scientist with primary interests in the use of human tissue to study human eye disease. In particular, I am interested in wound-healing events that follow cataract surgery, which lead to a secondary visual loss known as posterior capsule opacification (PCO). Through the use of human tissue the laboratory aims to further our understanding of the cell and molecular mechanisms underpinning PCO and identify novel targets for future therapeutic development.

近期论文

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Wormstone, I. M., Eldred, J. A.(2016)Experimental models for posterior capsule opacification researchin Experimental Eye Research142.pp. 2-12 Full Text UEA Repository(Article) Smith, A. F., Klotz, A., Wormstone, I. M.(2016)Improving the drug development process by reducing the impact of adverse events: the case of cataracts consideredin Drug Discovery Today21.pp. 510-516 Full Text UEA Repository(Article) Raghavan, C., Smuda, M., Smith, A., Howell, S., Smith, D., Singh, A., Gupta, P., Glomb, M., Wormstone, I., Nagaraj, R.(2016)AGEs in human lens capsule promote the TGFβ2-mediated EMT of lens epithelial cells: Implications for age-associated fibrosisin Aging Cell15.pp. 465–476 Full Text UEA Repository(Article) Smith, A., Ball, S., Bowater, R., Wormstone, I.(2016)PARP-1 inhibition influences the oxidative stress response of the human lensin Redox Biology8.pp. 354-362 Full Text UEA Repository(Article) Eldred, J. A., McDonald, M., Wilkes, H. S., Spalton, D. J., Wormstone, I. M.(2016)Growth factor restriction impedes progression of wound healing following cataract surgery: identification of VEGF as a putative therapeutic targetin Scientific Reports6. Full Text UEA Repository(Article) Smith, A. J. O., Ball, S. S. R., Manzar, K., Bowater, R. P., Wormstone, I. M.(2015)Ku80 Counters Oxidative Stress-Induced DNA Damage and Cataract Formation in the Human Lensin Investigative Ophthalmology and Visual Science56.pp. 7868-7874 Full Text UEA Repository(Article) Spalton, D. J., Russell, S. L., Evans-Gowing, R., Eldred, J. A., Wormstone, I. M.(2014)Effect of total lens epithelial cell destruction on intraocular lens fixation in the human capsular bagin Journal of Cataract and Refractive Surgery40.pp. 306-312 Full Text UEA Repository(Article) Eldred, J. A., Spalton, D. J., Wormstone, I. M.(2014)An In Vitro Evaluation of the Anew Zephyr Open-Bag IOL in the Prevention of Posterior Capsule Opacification Using a Human Capsular Bag Modelin Investigative Ophthalmology and Visual Science55.pp. 7057-7064 Full Text UEA Repository(Article) Wormstone, I., Eldred, J., Dawes, L.(2014)Fibrotic modifications of the lens epitheliumSpringerpp. 143-158ISBN 978-4-431-54299-5(Chapter (peer-reviewed))Liu, H., Smith, A. J., Lott, M. C., Bao, Y., Bowater, R. P., Reddan, J. R., Wormstone, I. M.(2013)Sulforaphane Can Protect Lens Cells Against Oxidative Stress: Implications for Cataract Preventionin Investigative Ophthalmology & Visual Science54.pp. 5236-5248 Full Text UEA Repository(Article) Fang, C., Illingworth, C. D., Qian, L., Wormstone, I. M.(2013)Serum Deprivation Can Suppress Receptor-Mediated Calcium Signaling in Pterygial-Derived Fibroblastsin Investigative Ophthalmology & Visual Science54.pp. 4563-4570 Full Text UEA Repository(Article) Dawes, L. J., Duncan, G., Wormstone, I. M., Cells, Cultured, Lens, Crystalline(2013)Age-related differences in signaling efficiency of human lens cells underpin differential wound healing response rates following cataract surgeryin Investigative Ophthalmology & Visual Science54.pp. 333-42 Full Text UEA Repository(Article) Dawes, L., Illingworth, C., Wormstone, I.(2012)A fully human in vitro capsular bag model to permit intraocular lens evaluationin Investigative Ophthalmology & Visual Science53.pp. 23-29 Full Text UEA Repository(Article) Eldred, J., Hodgkinson, L., Dawes, L., Reddan, J., Edwards, D., Wormstone, I.(2012)MMP2 Activity is Critical for TGF 2-Induced Matrix Contraction--Implications for Fibrosisin Investigative Ophthalmology & Visual Science53.pp. 4085-4098 Full Text UEA Repository(Article) Rhodes, J., Lott, M., Russell, S., Moulton, V., Sanderson, J., Wormstone, I., Broadway, D.(2012)Activation of the innate immune response and interferon signalling in myotonic dystrophy type 1 and type 2 cataractsin Human Molecular Genetics21.pp. 852-862 Full Text UEA Repository(Article) Wang, L., Eldred, J. A., Sidaway, P., Sanderson, J., Smith, A. J. O., Bowater, R. P., Reddan, J. R., Wormstone, I. M.(2012)Sigma 1 receptor stimulation protects against oxidative damage through suppression of the ER stress responses in the human lensin Mechanisms of Ageing and Development133.pp. 665-674 Full Text UEA Repository(Article) Eldred, J., Dawes, L., Wormstone, I.(2011)The lens as a model for fibrotic diseasein Philosophical Transactions of the Royal Society B: Biological Sciences366.pp. 1301-1319 Full Text UEA Repository(Article) Hodgkinson, L., Wang, L., Duncan, G., Edwards, D., Wormstone, I.(2010)ADAM and ADAMTS gene expression in native and wound healing human lens epithelial cellsin Molecular Vision16.pp. 2765-2776 UEA Repository(Article) Wormstone, I.(2010)Posterior Capsule OpacificationAcademic Presspp. 469-475ISBN 9780123742032(Chapter (peer-reviewed))Rhodes, J., Russell, S., Illingworth, C., Duncan, G., Wormstone, I.(2009)Regional Differences in Store-Operated Ca2+ Entry in the Epithelium of the Intact Human Lensin Investigative Ophthalmology & Visual Science50.pp. 4330-4336 Full Text UEA Repository(Article)