Williams, Mark - University of East Anglia - School of Biological Sciences

个人简介

Senior Lecturer in Cell Biology (2004-present) Lecturer in Cell Biology, University of East Anglia (1995-2004) Postdoctoral Research Associate, University of East Anglia (1993-1995) Ph.D. – School of Biological Sciences, University of East Anglia (1993) B.Sc. - Biophysics, University of East Anglia (1989)

研究领域

I am a physiologist interested in the cellular and molecular mechanisms that govern the self-renewal and physiological function of the human intestinal epithelium. A major focus of our work is to understand how age-related molecular damage and inherited genetic defects pre-dispose the intestinal epithelium to the onset of gastrointestinal disease. The ethos of our work is to conduct comparative studies on human tissue samples derived from young and old healthy subjects, and from patients with inflammatory bowel disease and cancer. To this end, our laboratory has developed an ex vivo culture model of the human intestinal epithelium that is amenable to bio-imaging and the investigation of cellular signals for crypt cell proliferation, migration, differentiation and secretion.

近期论文

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Parris, A., Williams, M.(2015)A human colonic crypt culture system to study regulation of stem cell-driven tissue renewal and physiological functionin Methods in Molecular Biology1212.pp. 141-161 Full Text UEA Repository(Article) Reynolds, A., Wharton, N., Parris, A., Mitchell, E., Sobolewski, A., Kam, C., Bigwood, L., El Hadi, A., Münsterberg, A., Lewis, M., Speakman, C., Stebbings, W., Wharton, R., Sargen, K., Tighe, R., Jamieson, C., Hernon, J., Kapur, S., Oue, N., Yasui, W., Williams, M., Aged, 80 and over, Microscopy, Confocal(2014)Canonical Wnt signals combined with suppressed TGFβ/BMP pathways promote renewal of the native human colonic epitheliumin Gut63.pp. 610-621 Full Text UEA Repository(Article) Skoczek, D. A., Walczysko, P., Horn, N., Parris, A., Clare, S., Williams, M., Sobolewski, A.(2014)Luminal Microbes Promote Monocyte-Stem Cell Interactions Across a Healthy Colonic Epitheliumin Journal of Immunology193.pp. 439-451 Full Text UEA Repository(Article) Belshaw, N., Pal, N., Tapp, H., Dainty, J., Lewis, M., Williams, M., Lund, E., Johnson, I.(2010)Patterns of DNA methylation in individual colonic crypts reveal aging and cancer-related field defects in the morphologically normal mucosain Carcinogenesis31.pp. 1158-1163 Full Text UEA Repository(Article) Scobioala-Laker, N., Reynolds, A., Parris, A., Mitchell, E., Lewis, M., Kennedy, H., Stebbings, W., Prior, A., Phillips, M., Beales, I., Williams, M.(2009)A Novel 3D Ex Vivo Model of Native Human Barrett's Oesophagus UEA Repository(Paper)Reynolds, A., Parris, A., Evans, L., Lindqvist, S., Sharp, P., Lewis, M., Tighe, R., Williams, M.(2007)Dynamic and differential regulation of NKCC1 by calcium and cAMPin the native human colonic epitheliumin The Journal of Physiology582.pp. 507-524 Full Text UEA Repository(Article) Williams, M., Spahos, T., Reynolds, A., Parris, A., Tighe, R., Speakman, C., Beales, I., Lewis, M.(2007)Taurodeoxycholic acid induces calcium oscillations in isolated human colonic cryptsin Gastroenterology132.pp. 8 UEA Repository(Article) Parris, A., Reynolds, A., Spahos, A., Munsterberg, A., Tighe, R., Lewis, M., Cook, J., Prior, A., Speakman, C., Stebbings, [. V., Hernon, J., Beales, I., Ellamin, K., Williams, M.(2006)Human colonic crypt renewal ex vivo.in Gastroenterology130.pp. 1677 UEA Repository(Article) Parris, A., Reynolds, A., Spahos, T., Williams, M.(2005)Wnt signalling mobilises beta-catenin and stimulates cell proliferation in isolated human colonic cryptsin Gastroenterology128.pp. 489 UEA Repository(Article) Reynolds, A., Addison, S., Lindqvist, S., Williams, M.(2005)Propagating calcium signals along human colonic crypts dynamically regulate NKCC1 phosphorylation and activity.in Gastroenterology128.pp. 357-358 UEA Repository(Article) Parris, A., Reynolds, A., Addison, S., Lindqvist, S., Hernon, J., Spahos, T., Tighe, T., Lewis, M., Mackay, J., Westgarth, D., Fellows, F., Bell, D., Kapur, S., Prior, A., Williams, M.(2004)Spatial correlation between acetylcholine-induced calcium signals and acetylcholine-induced cell proliferation along the isolated human colonic crypt axis.in Gastroenterology126.pp. 140 UEA Repository(Article) Addison, S., Lindqvist, S., Setchell, O., Hernon, J., Tighe, R., Rhodes, M., Stebbings, W., Williams, M.(2003)Top-down aberrant calcium signals in colonic crypts derived from the flat mucosa of polyp- and colorectal cancer-patientsin Gastroenterology124.pp. A282 Full Text UEA Repository(Article) Addison, S., Lindqvist, S., Setchell, O., Hernon, J., Tighe, R., Mackay, J., Rhodes, M., Stebbings, W., Williams, M.(2003)Prostaglandin E2 induces calcium signals in the proliferative zone of isolated human colonic cryptsin Gastroenterology124.pp. A276-A276 Full Text UEA Repository(Article) Hernon, J., Lindqvist, S., Prior, A., Williams, M.(2003)Carbachol induces ERK 1/2 activation and stimulates cell proliferation via a metalloproteinase- and TGFá dependent pathwayin Gastroenterology124.pp. 285 Full Text UEA Repository(Article) Olano-Martin, E., Williams, M., Gibson, G. R., Rastall, R. A.(2003)Pectins and pectic-oligosaccharides inhibit Escherichia coliO157:H7 Shiga toxin as directed towards the human colonic cell line HT29in FEMS Microbiology Letters218.pp. 101-105 Full Text UEA Repository(Article) Hernon, J., Lindqvist, S., Rhodes, M., Speakman, C., Stebbings, W., Williams, M.(2002)Acetylcholine stimulates Human Colonic epithelial cell growth via calcium dependent MAP Kinase activationin Colorectal Diseasepp. 4-41 UEA Repository(Article) Hernon, J., Lindqvist, S., Rhodes, M., Speakman, C., Tighe, R., Murphy, G., Stebbings, W., Williams, M.(2002)Molecular mechanisms of acetylcholine-induced ERK1/2 activation in HT29 cells and isolated human colonic cryptsin Gastroenterology122.pp. 991-991 UEA Repository(Article) Hotchkiss, A., Olano-Martin, E., Williams, M., Grace, W., Gibson, G., Rastall, R.(2002)Pectic oligosaccharides as prebiotics.in Abstracts of Papers of the American Chemical Society223.pp. 34 UEA Repository(Article) Lindqvist, S., Hernon, J., Sharp, P., Johns, N., Addison, S., Watson, M., Tighe, R., Greer, S., Mackay, J., Rhodes, M., Lewis, M., Stebbings, W., Speakman, C., Evangelista, S., Johnson, I., Williams, M., Dose-Response Relationship, Drug, Receptor, Muscarinic M3, Receptors, Muscarinic(2002)The colon-selective spasmolytic otilonium bromide inhibits muscarinic M(3) receptor-coupled calcium signals in isolated human colonic cryptsin British Journal of Pharmacology137.pp. 1134-1142 Full Text UEA Repository(Article) Sharp, P., Tandy, S., Yamaji, S., Tennant, J., Williams, M., Singh Srai, S. K.(2002)Rapid regulation of divalent metal transporter (DMT1) protein but not mRNA expression by non-haem iron in human intestinal Caco-2 cellsin FEBS Letters510.pp. 71-76 Full Text UEA Repository(Article)