Wheeler, Grant - University of East Anglia - School of Biological Sciences

个人简介

Reader in Cell and Developmental Biology 2015-present Senior Lecturer in Cell & Developmental Biology 2010-2014 Lecturer in Cell and Developmental Biology at University of East Anglia, Norwich, England, 2001-2009 Postdoctoral Research Associate and Honorary Lecturer in the lab of Dr Stefan Hoppler, University of Dundee. Studying Wnt signalling in Xenopus development. 1998-2001. Postdoctoral Research Assistant in the lab of Prof. Birgitte Lane, University of Dundee. Looking at the biology of plectin, a component of hemidesmosomes. 1996-1998. Postdoctoral research with Prof. Richard Hynes at the MIT, Cambridge, MA, U.S.A. Studying cytoskeletal interactions of integrins. 1992-1996 Postgraduate studies at the N.I.M.R. in Mill Hill, London, U.K. with Dr. Tony Magee on the cell and molecular biology of desmosomes. 1988-1991 Undergraduate studies in Biochemistry at King's College, University of London, including a sandwich year at the Advanced Drug Delivery Research Unit, Ciba Geigy, Horsham. 1984-1988

研究领域

My group works on the molecular events that govern the origin and migration of different cell types within the developing embryo. The model organism we use is the amphibian Xenopus laevis.

近期论文

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Webster, C., Di Silvio, D., Devarajan, A., Bigini, P., Micotti, E., Giudice, C., Salmona, M., Wheeler, G., Sherwood, V., Baldelli Bombelli, F.(2016)An early developmental vertebrate model for nanomaterial safety: bridging cell-based and mammalian toxicity assessmentin Nanomedicine11.pp. 643-656 Full Text UEA Repository(Article) Hatch, V., Marin Barba, M., Moxon, S., Ford, C., Ward, N., Tomlinson, M., Desanlis, I., Hendry, A., Hontelez, S., van Krujsbergen, I., Veenstra, G. J., Munsterberg, A., Wheeler, G.(2016)The positive transcriptional elongation factor (P-TEFb) is required for neural crest specificationin Developmental Biology416.pp. 361–372 Full Text UEA Repository(Article) Abu-Elmagd, M., Goljanek-Whysall, K., Wheeler, G., Munsterberg, A.(2015)Sprouty2 mediated tuning of signalling is essential for somite myogenesisin BMC Medical Genomics8. Full Text UEA Repository(Article) About-Elhamd, A., Alrefaei, A., Mok, G. F. (., Garcia-Morales, C., Abu-Elmagd, M., Wheeler, G., Munsterberg, A.(2015)Klhl31 attenuates β-catenin dependent Wnt signaling and regulates embryo myogenesisin Developmental Biology402.pp. 61-71 Full Text UEA Repository(Article) Kelwick, R., Desanlis, I., Wheeler, G. N., Edwards, D. R.(2015)The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) familyin Genome Biology16. Full Text UEA Repository(Article) Hoppler, S., Wheeler, G.(2015)It's about time for neural crestin Science348.pp. 1316-1317 Full Text UEA Repository(Article) Ahmed, A., Ward, N. J., Moxon, S., Lopez-Gomollon, S., Viaut, C., Tomlinson, M. L., Patrushev, I., Gilchrist, M. J., Dalmay, T., Dotlic, D., Munsterberg, A. E., Wheeler, G. N.(2015)A Database of microRNA Expression Patterns in Xenopus laevisin PLoS ONE10. Full Text UEA Repository(Article) Song, J., Mccoll, J., Camp Navarro, E., Kennerley, N., Mok, G., Mccormick, D., Grocott, T., Wheeler, G., Munsterberg, A.(2014)Smad1 transcription factor integrates BMP2 and Wnt3a signals in migrating cardiac progenitor cellsin Proceedings of the National Academy of Sciences111.pp. 7337-7342 Full Text UEA Repository(Article) Drakakis, G., Hendry, A., Hanson, K., Brewerton, S., Bodkin, M., Evans, D., Wheeler, G., Bender, A.(2014)Bioactivity Profile Analysis from Automated Phenotype Detection in Xenopus laevis Using Image Processingin MedChemComm5.pp. 386-396 Full Text UEA Repository(Article) Goljanek-Whysall, K., Mok, G. F., Alrefaei, A., Kennerley, N., Wheeler, G., Munsterberg, A.(2014)myomiR-dependent switching of BAF60 variant incorporation into Brg1 chromatin remodeling complexes during embryo myogenesisin Development141.pp. 3378-3387 Full Text UEA Repository(Article) Liggi, S., Drakakis, G., Hendry, A., Hanson, K., Brewerton, S., Wheeler, G., Bodkin, M., Evans, D., Bender, A.(2013)Extensions to In Silico Bioactivity Predictions Using Pathway Annotations and Differential Pharmacology Analysis: Application to Xenopus laevis Phenotypic Readoutsin Molecular Informatics32.pp. 1009-1024 Full Text UEA Repository(Article) Wheeler, G., Field, R., Tomlinson, M.(2012)Phenotypic screens with model organismsCambridge University Presspp. 121-136ISBN 978-0521889483 UEA Repository(Chapter)Wheeler, G., Liu, K.(2012)Xenopus: An ideal system for chemical geneticsin genesis50.pp. 207-218 Full Text UEA Repository(Article) Tomlinson, M., Henry, A., Wheeler, G.(2012)Chemical genetics and drug discovery in Xenopusin Methods in Molecular Biology917.pp. 155-166 UEA Repository(Article) White, R., Cech, J., Ratanasirintrawoot, S., Lin, C., Rahl, P., Burke, C., Langdon, E., Tomlinson, M., Mosher, J., Kaufman, C., Chen, F., Long, H., Kramer, M., Datta, S., Neuberg, D., Granter, S., Young, R., Morrison, S., Wheeler, G., Zon, L.(2011)DHODH modulates transcriptional elongation in the neural crest and melanomain Nature471.pp. 518-522 Full Text UEA Repository(Article) Abou-Elhamd, A., Cooper, O., Garcia-Morales, C., Wheeler, G., Munsterberg, A.(2009)Klhl31 is regulated by myogenic signals in developing somites and modulates Wnt signaling in vitro and in vivo()Garcia-Morales, C., Liu, C., Abu-Elmagd, M., Hajihosseini, M., Wheeler, G.(2009)Frizzled-10 promotes sensory neuron development in Xenopus embryosin Developmental Biology335.pp. 143-155 Full Text UEA Repository(Article) Tomlinson, M., Guan, P., Morris, R., Fidock, M., Rejzek, M., Garcia Morales, C., Field, R., Wheeler, G.(2009)A chemical genomic approach identifies matrix metalloptroteinases as playing an essential and specific role in Xenopus melanophore migrationin Chemistry and Biology16.pp. 93-104 Full Text UEA Repository(Article) Tomlinson, M., Rejzek, M., Fidock, M., Field, R., Wheeler, G.(2009)Chemical genomics identifies compounds affecting Xenopus laevis pigment cell developmentin Molecular BioSystems4.pp. 376-384 Full Text UEA Repository(Article) Wheeler, G., Brandli, A.(2009)Simple vertebrate models for chemical genetics and drug discovery screens: Lessons from zebrafish and Xenopusin Developmental Dynamics238(6).pp. 1287-1308 Full Text UEA Repository(Article)