Watmough, Nick - University of East Anglia - School of Biological Sciences

个人简介

Nick studied biochemistry at Imperial College, London and after graduating in 1982 worked as a research technician in the Muscular Dystrophy Labs at Newcastle General Hospital. In 1984 he moved to the Medical School where he completed a PhD under the supervision of Doug Turnbull. This was followed by postdoctoral work at the University of Colorado Health Sciences Centre (1989-90) before arriving at UEA as a postdoctoral fellow in November 1990. The award of one of the first Wellcome Trust Career Development Award Fellowships in 1994 was followed in 1998 by a Wellcome Trust University Award both held in BIO. Nick was appointed to a Readership in 2001 and since then he has held a number of School and Faculty administrative roles including a period as Associate Dean, Learning and Teaching for SCI (2006-2009). He currently serves as a trustee and treasurer of the Biochemical Society and is the University's Academic Director of Postgraduate Research Degree Programmes. Career History University Academic Director for Postgraduate Research Degree Programmes (2012-2015) Reader in Biochemistry, University of East Anglia (2001-present) Associate Dean (LTQ), Faculty of Science, University of East Anglia (2007-2010) Wellcome Trust University Award Lecturer, University of East Anglia (1998-2003) Wellcome Trust Career Development Award Fellow, University of East Anglia (1994-1998) Postdoctoral Fellow, University of East Anglia (1990-1994) Postdoctoral Fellow, University of Colorado Health Sciences Center (1989-1990) Ph.D. - University of Newcastle-upon-Tyne (1989) B.Sc. - Biochemistry, Imperial College of Science Technology and Medicine (1982)

研究领域

I am a biochemist with interests in heme containing proteins, respiratory enzymes and bioenergetics. In the recent past my research has focused on bacterial enzymes and is closely integrated with a number of other groups in the Centre for Molecular and Structural Biochemistry (CMSB). More recently I have started to collaborate with colleagues in the Biomedical Research Centre to better understand the role of vertebrate globins in cellular and animal models of disease.

近期论文

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Terpolilli, J. J., Masakapalli, S. K., Karunakaran, R., Webb, I. U. C., Green, R., Watmough, N. J., Kruger, N. J., Ratcliffe, R. G., Poole, P. S.(2016)Lipogenesis and redox balance in nitrogen-fixing pea bacteroidsin Journal of Bacteriology198.pp. 2864-2875 Full Text UEA Repository(Article) Van Wonderen, J. H., Oganesyan, V. S., Watmough, N. J., Richardson, D. J., Thomson, A. J., Cheesman, M. R.(2013)Unexpected weak magnetic exchange coupling between haem and non-haem iron in the catalytic site of nitric oxide reductase (NorBC) from Paracoccus denitrificans.in Biochemical Journal451.pp. 389-394 Full Text UEA Repository(Article) Clarke, T., Edwards, M., Gates, A., Hall, A., White, G., Bradley, J., Reardon, C., Shi, L., Beliaev, A., Marshall, M., Wang, Z., Watmough, N., Fredrickson, J., Zachara, J., Butt, J., Richardson, D.(2011)Structure of a bacterial cell surface decaheme electron conduitin Proceedings of the National Academy of Sciences108.pp. 9384-9389 Full Text UEA Repository(Article) Clarke, T., Fairhurst, S., Lowe, D. J., Watmough, N., Eady, R. R.(2011)Electron transfer and half-reactivity in nitrogenasein Biochemical Society Transactions39.pp. 201-206 Full Text UEA Repository(Article) Crack, J., Smith, L., Stapleton, M., Peck, J., Watmough, N., Buttner, M., Buxton, R., Green, J., Oganesyan, V., Thomson, A., Le Brun, N.(2011)Mechanistic Insight into the Nitrosylation of the [4Fe−4S] Cluster of WhiB-like Proteinsin Journal of the American Chemical Society133.pp. 1112-1121 Full Text UEA Repository(Article) Field, S., Roldan, M., Marritt, S., Butt, J., Richardson, D., Watmough, N.(2011)Electron transfer to the active site of the bacterial nitric oxide reductase is controlled by ligand binding to heme b3in Biochimica et Biophysica Acta (BBA) - Bioenergetics1807.pp. 451-457 Full Text UEA Repository(Article) Martínez‑Espinosa, R. M., Cole, J. A., Richardson, D., Watmough, N.(2011)Enzymology and ecology of the nitrogen cyclein Biochemical Society Transactions39.pp. 175-178 Full Text UEA Repository(Article) Ozturk, M., Watmough, N.(2011)Mutagenesis of tyrosine residues within helix VII in subunit I of the cytochrome cbb3 oxidase from Rhodobacter capsulatusin Molecular Biology Reports38.pp. 3319-3326 Full Text UEA Repository(Article) Todd, J., Curson, A., Nikolaidou-Katsaraidou, N., Brearley, C., Watmough, N., Chan, Y., Bulman Page, P., Sun, L., Johnston, A.(2010)Molecular dissection of bacterial acrylate catabolism - unexpected links with dimethylsulfoniopropionate catabolism and dimethyl sulfide productionin Environmental Microbiology12.pp. 327-343 Full Text UEA Repository(Article) Watmough, N., Frerman, F. E.(2010)The electron transfer flavoprotein: Ubiquinone oxidoreductasesin Biochimica et Biophysica Acta (BBA) - Bioenergetics1797.pp. 1910-1916 Full Text UEA Repository(Article) Becker, C., Watmough, N., Elliott, S.(2009)Electrochemical evidence for multiple peroxidatic heme states of the diheme cytochrome c peroxidase of Pseudomonas aeruginosain Biochemistry48.pp. 87-95 Full Text UEA Repository(Article) Flock, U., Lachmann, P., Reimann, J., Watmough, N., Adelroth, P.(2009)Exploring the terminal region of the proton pathway in the bacterial nitric oxide reductasein Journal of Inorganic Biochemistry103.pp. 845-850 Full Text UEA Repository(Article) Richardson, D., Felgate, H., Watmough, N., Thomson, A., Baggs, E.(2009)Mitigating release of the potent greenhouse gase N2O from the nitrogen cyclein Trends in Biotechnology27.pp. 288-297 Full Text UEA Repository(Article) Watmough, N., Field, S., Hughes, R., Richardson, D.(2009)The bacterial respiratory nitric oxide reductasein Biochemical Society Transactions37.pp. 392-399 Full Text UEA Repository(Article) Flock, U., Thorndycroft, F., Matorin, A., Richardson, D., Watmough, N., Adelroth, P.(2008)Defining the proton entry point in the bacterial respiratory nitric oxide reductasein Journal of Biological Chemistry283.pp. 3839-3845 Full Text UEA Repository(Article) Fielding, A., Usselman, R., Watmough, N., Simkovic, M., Frerman, F., Eaton, G., Eaton, S.(2008)Electron Spin Relaxation Enhancement Measurements of Interspin Distances in Human, Porcine and Rhodobacter Electron Transfer Flavoprotein-ubiquinone Oxidoreductase (ETF-QO)in Journal of Magnetic Resonance190.pp. 222-232 Full Text UEA Repository(Article) Echalier, A., Brittain, T., Wright, T., Boycheva, S., Mortuza, G., Fulop, V., Watmough, N.(2008)Redox-linked structural changes associated with the formation of a catalytically competent form of the dihaem cytochrome c peroxidase from Pseudomonas aeruginosain Biochemistry47.pp. 1947-1956 Full Text UEA Repository(Article) Field, S., Thorndycroft, F., Matorin, A., Richardson, D., Watmough, N.(2008)The Paracoccus denitrificans respiratory NO reductase (NorBC)in Methods in Enzymology437.pp. 79-101 Full Text UEA Repository(Article) Kapetanaki, S., Field, S., Hughes, R., Watmough, N., Liebl, U., Vos, M.(2008)Ultrafast Ligand Binding Dynamics in the Active Site of Native Bacterial Nitric Oxide Reductasein Biochimica et Biophysica Acta - Bioenergetics1777.pp. 919-924 Full Text UEA Repository(Article) Usselman, R., Fielding, A., Frerman, F., Watmough, N., Eaton, G., Eaton, S.(2008)Impact of Mutations on the Midpoint Potential of the [4Fe-4S]+1,+2 Cluster and on Catalytic Activity in Electron Transfer Flavoprotein-ubiquinone Oxidoreductase (ETF-QO)in Biochemistry47.pp. 92-100 Full Text UEA Repository(Article)