Thomas, Colwyn - University of East Anglia - School of Biological Sciences

个人简介

B.Sc. - Plant Science, University College Cardiff (1981) Ph.D. - University College Cardiff (1984) Post-doctoral researcher, Department of Applied Genetics, John Innes Centre (1984-1988) Senior post-doctoral researcher, Sainsbury Laboratory, John Innes Centre (1989-2001) Lecturer in Biology, University of East Anglia (2001-2009) Senior Lecturer in Biology, University of East Anglia (2009-present)

研究领域

Despite significant advances in plant breeding and agriculture (such as the ‘Green Revolution’) there is still a major challenge to reduce crop losses that result from diseases caused by fungi, bacteria, viruses and nematodes. The Norwich Research Park has a world class reputation in the study of molecular plant pathology. It is hoped that a greater understanding of the molecular interactions that control pathogen infection will have direct applications in creating disease resistant crops. My lab-based research career was focused on the molecular interactions between plants and their pathogens (particularly fungi and viruses), together with the genetic organisation and evolution of plant disease resistance gene loci. This research utilised several model plant-pathogen interactions to determine the genetic and molecular basis of resistance to pathogen infection using primarily the interaction between tomato and the leaf mold pathogen Cladosporium fulvum. In collaboration with Dr Mark Stevens at the British Beet Research Organisation we have also studied the interaction between the economically important luteoviruses and their hosts, including sugar beet and oilseed rape. In the case of Beet Mild Yellows Virus (BMYV- which causes significant losses to the UK sugar beet crop) we have used the model plant Arabidopsis thaliana to identify host genes required for BMYV infection. We have also studied Turnip Yellows Virus which causes significant yield losses in UK oilseed rape.

近期论文

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Soumpourou, E., Iakovidis, M., Chartrain, L., Lyall, V., Thomas, C.(2007)The 'Solanum pimpinellifolium' 'Cf-ECP1' and 'Cf-ECP4' genes for resistance to 'Cladosporium fulvum' are located at the 'Milky Way' locus on the short arm of chromosome 1in Theoretical and Applied Genetics115.pp. 1127-1136 Full Text UEA Repository(Article) Thomas, C., Jones, J.(2007)Molecular analysis of Agrobacterium T-DNA integration in tomato reveals a role for left border sequence homology in most integration events.in Molecular Genetics and Genomics278.pp. 411-420 Full Text UEA Repository(Article) Ledger, W., Anumba, D., Marlow, N., Thomas, C., Wilson, E.(2006)The costs to the NHS of multiple births after IVF treatment in the UKin British Journal of Obstetrics & Gynaecology113.pp. 21-5 UEA Repository(Article) Rivas, S., Thomas, C.(2005)Molecular interactions between tomato and the leaf mold pathogen Cladosporium fulvum.in Annual Review of Phytopathology43.pp. 395-436 Full Text UEA Repository(Article) Wulff, B., Kruijt, M., Collins, P., Thomas, C., Ludwig, A., De Wit, P., Jones, J.(2004)Gene shuffling-generated and natural variants of the tomato resistance gene Cf-9 exhibit different auto-necrosis-inducing activities in Nicotiana species.in The Plant Journal40.pp. 942-956 Full Text UEA Repository(Article) Wulff, B., Thomas, C., Parniske, M., Jones, J.(2004)Genetic variation at the tomato Cf-4/Cf-9 locus induced by EMS mutagenesis and intralocus recombination.in Genetics167.pp. 459-470 Full Text UEA Repository(Article) Briza, J., Niedermeierova, H., Pavingerova, D., Thomas, C., Klimyuk, V., Jones, J.(2002)Transposition patterns of unlinked transposed Ds elements from two T-DNA loci on tomato chromosomes 7 and 8.in Molecular Genetics and Genomics266.pp. 882-890 Full Text UEA Repository(Article) Rivas, S., Thomas, C.(2002)Recent advances in the study of tomato Cf resistance genes.in Molecular Plant Pathology3.pp. 277-282 Full Text UEA Repository(Article) Thomas, C., Kruger, J., Mulder, L., Jones, J. D. G., Smoker, M., Goldstein, C., Dixon, M. S., Tang, S.(2002)A tomato cysteine protease required for Cf-2-dependent disease resistance and suppression of autonecrosisin Science296.pp. 744-747 Full Text UEA Repository(Article) Bertioli, D., Guimraes, P., Jones, J., Thomas, C., Burrows, P., Monte, D., Leal-Bertioli, S.(2001)Expression of tomato Cf genes and their corresponding avirulence genes in transgenic tobacco plants using nematode responsive promoters.in Annals of Applied Biology138.pp. 333-342 Full Text UEA Repository(Article) Wulff, B., Thomas, C., Smoker, M., Grant, M., Jones, J.(2001)Domain swapping and gene shuffling identify sequences required for induction of an Avr-dependent hypersensitive response by the tomato Cf-4 and Cf-9 proteinsin The Plant Cell13.pp. 255-272 Full Text UEA Repository(Article)