Miller, Ben - University of East Anglia - School of Biological Sciences

个人简介

Ben Miller is the Eastern ARC Fellow in Synthetic Biology at the University of East Anglia. Ben is a molecular biologist with an interest in calcium signalling pathways and synthetic biology in plants. His research is focussed on how plants use calcium as a second messenger to respond and adapt to the environment. Career History Eastern ARC Fellow in Synthetic Biology, University of East Anglia (2015 - Present) Post-doctoral Scientist, John Innes Centre (2012 - 2015) PhD, John Innes Centre (2012) BSc, University of Durham (2008)

研究领域

Plants use calcium as a second messenger in signal transduction pathways associated with many different biological processes, for example during drought, salt or cold stress, and during interactions with pathogens or symbionts. These different stimuli are able to induce different calcium signals in plant cells, but it is unclear how these different calcium signals bring about further specific responses. Many calcium-binding proteins have been identified in plants and most of these proteins possess EF-hand motifs which have been shown to directly bind calcium ions. We are interested in understanding how these calcium-binding proteins decode different calcium signals into specific signalling responses. If you are interested in a postdoctoral position in our laboratory, please e-mail me directly to discuss possibilities. We are very interested in potential postdocs with a strong background in plant biology, synthetic biology or biochemistry. Applicants are encouraged to look for funding sources

近期论文

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Sun, J., Miller, J. B., Granqvist, E., Wiley-Kalil, A., Gobbato, E., Maillet, F., Cottaz, S., Samain, E., Venkateshwaran, M., Fort, S., Morris, R. J., Ané, J., Dénarié, J., Oldroyd, G. E. D.(2015)Activation of symbiosis signaling by arbuscular mycorrhizal fungi in legumes and ricein The Plant Cell27.pp. 823-838 Full Text UEA Repository(Article) Patron, N. J., Orzaez, D., Marillonnet, S., Warzecha, H., Matthewman, C., Youles, M., Raitskin, O., Leveau, A., Farré, G., Rogers, C., Smith, A., Hibberd, J., Webb, A. A. R., Locke, J., Schornack, S., Ajioka, J., Baulcombe, D. C., Zipfel, C., Kamoun, S., Jones, J. D. G., Kuhn, H., Robatzek, S., Van Esse, H. P., Sanders, D., Oldroyd, G., Martin, C., Field, R., O'Connor, S., Fox, S., Wulff, B., Miller, B., Breakspear, A., Radhakrishnan, G., Delaux, P., Loqué, D., Granell, A., Tissier, A., Shih, P., Brutnell, T. P., Quick, W. P., Rischer, H., Fraser, P. D., Aharoni, A., Raines, C., South, P. F., Ané, J., Hamberger, B. R., Langdale, J., Stougaard, J., Bouwmeester, H., Udvardi, M., Murray, J. A. H., Ntoukakis, V., Schäfer, P., Denby, K., Edwards, K. J., Osbourn, A., Haseloff, J.(2015)Standards for plant synthetic biology: a common syntax for exchange of DNA partsin New Phytologist208.pp. 13-19 Full Text UEA Repository(Article) Miller, J. B., Pratap, A., Miyahara, A., Zhou, L., Bornemann, S., Morris, R. J., Oldroyd, G. E. D.(2013)Calcium/Calmodulin-dependent protein kinase is negatively and positively regulated by calcium, providing a mechanism for decoding calcium responses during symbiosis signalingin The Plant Cell25.pp. 5053-5066 Full Text UEA Repository(Article) Routray, P., Miller, J. B., Du, L., Oldroyd, G., Poovaiah, B. W., Mutagenesis, Site-Directed(2013)Phosphorylation of S344 in the calmodulin-binding domain negatively affects CCaMK function during bacterial and fungal symbiosesin The Plant Journal76.pp. 287-96 Full Text UEA Repository(Article) Gobbato, E., Marsh, J. F., Vernié, T., Wang, E., Maillet, F., Kim, J., Miller, J. B., Sun, J., Bano, S. A., Ratet, P., Mysore, K. S., Dénarié, J., Schultze, M., Oldroyd, G. E. D., Gene Expression Regulation, Plant(2012)A GRAS-type transcription factor with a specific function in mycorrhizal signalingin Current Biology22.pp. 2236-2241 Full Text UEA Repository(Article)