Mayer, Ulrike - University of East Anglia - School of Biological Sciences

个人简介

During my undergraduate studies in Chemistry I majored in Biochemistry. I therefore decided to carry out a biochemical PhD project on hyaluronan at the Max-Planck-Institute of Biochemistry in Martinsried/Germany. In 1988, I joined Dr. Rupert Timpl, a world-renowned expert in extracellular matrix proteins, as a post-doc at the Max-Planck-Institute and worked mainly on the structure/function relationship of extracellular matrix/basement membrane proteins. Research to which I have contributed has involved the biochemical study of nidogen, a major component of basement membranes, and the identification of its binding repertoire to collagen type IV, perlecan and laminin. Of special importance was the identification of the nidogen-binding site within the laminin g1 chain, its characterisation as a single epidermal growth factor-like module of 56 amino acids and its structural characterisation. This work had world-wide impact and generated a model how basement membranes are assembled. In 1992, I moved to the Max-Planck Research Group for extracellular matrix in Erlangen. During that period I initiated in vivo analysis of basement membrane proteins and their cellular receptors using mouse knock-out technology. From 1993-2001, I worked in the Max-Planck-Institute of Biochemistry in Martinsried/Germany as an independent senior scientist in the Department of Protein Chemistry (head: Dr. Rupert Timpl) and established my research group. We were first in demonstrating that mutations in integrin alpha7 lead to a muscular dystrophy and we were amongst the first groups introducing subtle mutations in mice, which allowed us to study a protein-protein interaction in vivo. In 2000 I joined the Wellcome Trust Centre for Cell-Matrix research at the University of Manchester and finally moved to the School of Biological Sciences at the University of East Anglia in 2006 as Professor of Cell Biology. I am still deeply connected with the research area I was trained in as a PhD student and Post-doc, but am taking now a broader approach to understand disease mechanisms when cells fail to communicate with their environment, especially in skeletal muscle. Career History 2005 onwards, Professor of Cell Biology, Biomedical Research Centre, School of Biological Sciences, University of East Anglia, UK 2002-2005, Senior Lecturer in Biological Sciences, Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, UK 2000-2002, Lecturer in Dental Genetics, Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, UK 1994-2000, Junior Research Leader, Max-Planck-Institute of Bochemistry, Martinsried, Germany 1993, Research Assistant, Max-Planck-Research Group for Rheumatology and Immunology, University of Erlangen, Germany 1988-1992, Research Assistant, Department of Exracellular Matrix Research, Max-Planck-Institute of Biochemistry, Martinsried, Germany 1988, Ph.D. in Chemistry, 1988 Ludwig-Maximillian University of Munich, Germany 1984, Diploma in Chemistry Albert-Ludwigs-University of Freiburg, Germany

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Pellegatta, M., De Arcangelis, A., D'urso, A., Nodari, A., Zambroni, D., Ghidinelli, M., Matafora, V., Williamson, C., Georges-labouesse, E., Kreidberg, J., Mayer, U., Mckee, K. K., Yurchenco, P. D., Quattrini, A., Wrabetz, L., Feltri, M. L.(2013)α6β1 and α7β1 Integrins Are Required in Schwann Cells to Sort Axonsin The Journal of Neuroscience33.pp. 17995-18007 Full Text UEA Repository(Article) Elkina, Y., Palus, S., Tschirner, A., Hartmann, K., Von Haehling, S., Doehner, W., Mayer, U., Coats, A. J., Beadle, J., Anker, S. D., Springer, J.(2013)Tandospirone reduces wasting and improves cardiac function in experimental cancer cachexiain International Journal of Cardiology170.pp. 160-166 Full Text UEA Repository(Article) Ackroyd, M., Whitmore, C., Prior, S., Kaluarachchi, M., Nikolic, M., Mayer, U., Muntoni, F., Brown, S.(2011)Fukutin-Related Protein Alters the Deposition of Laminin in the Eye and Brainin The Journal of Neuroscience31.pp. 12927-12935 Full Text UEA Repository(Article) Mokkapati, S., Fleger-Weckmann, A., Bechtel, M., Koch, M., Breitkreutz, D., Mayer, U., Smyth, N., Nischt, R.(2011)Basement Membrane Deposition of Nidogen 1 but Not Nidogen 2 Requires the Nidogen Binding Module of the Laminin 1 Chainin Journal of Biological Chemistry286.pp. 1911-1918 Full Text UEA Repository(Article) Makwana, M., Werner, A., Acosta-Saltos, A., Gonitel, R., Pararajasingham, A., Ruff, C., Rumajogee, P., Cuthill, D., Galiano, M., Bohatschek, M., Wallace, A., Anderson, P., Mayer, U., Behrens, A., Raivich, G.(2010)Peripheral facial nerve axotomy in mice causes sprouting of motor axons into perineuronal central white matter: Time course and molecular characterizationin Journal of Comparative Neurology518.pp. 699-721 Full Text UEA Repository(Article) Aigner, B., Rathkolb, B., Klaften, M., Sedlmeier, R., Klempt, M., Wagner, S., Michel, D., Mayer, U., Klopstock, T., Hrabe de Angelis, M., Wolf, E.(2009)Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in plasma enzyme activities as novel organ-specific disease modelsin Experimental Physiology94.pp. 412-421 Full Text UEA Repository(Article) Han, R., Kanagawa, M., Yoshida-Moriguchi, T., Rader, E., Ng, R., Michele, D., Muirhead, D., Kunz, S., Moore, S., Iannaccone, S., Miyake, K., McNeil, P., Mayer, U., Oldstone, M., Faulkner, J., Campbell, K.(2009)Inaugural Article: Basal lamina strengthens cell membrane integrity via the laminin G domain-binding motif of -dystroglycanin Proceedings of the National Academy of Sciences106.pp. 12573-12579 Full Text UEA Repository(Article) Hager, M., Meszaros, R., Bigotti, M., Allamand, V., Akerlund, M., Kalamajski, S., Brancaccio, A., Mayer, U., Durbeej, M.(2008)Cib2 binds integrin 7B 1D and is reduced in laminin 2 chain deficient muscular dystrophyin Journal of Biological Chemistry283.pp. 24760-24769 Full Text UEA Repository(Article) Wang, H., Chang, L., Brixius, K., Wickstrom, S., Montanez, E., Thievessen, I., Schwander, M., Muller, U., Bloch, W., Mayer, U., Fassler, R.(2008)Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damagein Journal of Cell Biology180.pp. 1037-1049 Full Text UEA Repository(Article) Bass, M., Roach, K., Morgan, M., Mostafavi-Pour, Z., Schoen, T., Muramatsu, T., Mayer, U., Ballestrem, C., Spatz, J., Humphries, M.(2007)Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrixin Journal of Cell Biology177.pp. 527-538 Full Text UEA Repository(Article) Candiello, J., Balasubramani, M., Schreiber, E. M., Cole, G. J., Mayer, U., Halfter, W., Lin, H.(2007)Biomechanical properties of native basement membranesin FEBS Journal274.pp. 2897-2908 Full Text UEA Repository(Article) Hanft, L., Bogan, D., Mayer, U., Kaufman, S., Kornegay, J., Ervasti, J.(2007)Cytoplasmic y-actin expression in diverse animal models of muscular dystrophyin Neuromuscular Disorders17.pp. 569-574 Full Text UEA Repository(Article) Leclere, P., Norman, E., Groutsi, F., Coffin, R., Mayer, U., Pizzey, J., Tonge, D.(2007)Impaired axonal regeneration by isolectin B4-binding dorsal root ganglion neurons in vitro.in The Journal of Neuroscience27.pp. 1190-1199 Full Text UEA Repository(Article) Gawlika, K., Mayer, U., Blomberg, K., Sonnenberg, A., Ekblom, P., Durbeej, M.(2006)Laminin alpha1 chain mediated reduction of laminin alpha2 chain deficient muscular dystrophy involves integrin alpha7beta1 and dystroglycanin FEBS Letters580.pp. 1759-1765 Full Text UEA Repository(Article) Guo, C., Willem, M., Werner, A., Raivich, G., Emerson, M., Neyses, L., Mayer, U.(2006)Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophyin Human Molecular Genetics15.pp. 989-998 Full Text UEA Repository(Article) Haubst, N., Georges-Labouesse, E., De Arcangelis, A., Mayer, U., Gotz, M.(2006)Basement membrane attachment is dispensable for radial glial cell fate and for proliferation, but affects positioning of neuronal subtypes.in Development133.pp. 3245-3254 Full Text UEA Repository(Article) Macdonald, P., Progias, P., Ciani, B., Patel, S., Mayer, U., Steinmetz, M., Kammerer, R.(2006)Structure of the extracellular domain of tie receptor tyrosine kinases and localization of the angiopoietin-binding epitope.in Journal of Biological Chemistry281.pp. 28408-28414 Full Text UEA Repository(Article) Rogers, L., Mayer, U.(2006)Insights into integrin function in skeletal muscle.Landes Biosciencepp. 138-151 UEA Repository(Chapter)Smirnov, S., Harrison, D., Mckee, K., Mayer, U., Yurchenco, P.(2006)Laminin-nidogen interaction in the induction of AChR clustering. Full Text()Smith, N., Losty, P., Connell, M., Mayer, U., Jesudason, E.(2006)Abnormal lung development precedes oligohydramnios in a transgenic murine model of renal dysgenesisin Journal of Urology175.pp. 783-786 Full Text UEA Repository(Article)