Hutchings, Matthew - University of East Anglia - School of Biological Sciences

个人简介

1991 to 1994 University of Portsmouth. BSc (Hons) Biology. First Class 1994 to 1998 University of Southampton. Ph.D 1998 to 2001 University of East Anglia. Senior Research Associate 2001 to 2005 John Innes Centre. Project Scientist 2006 to 2010 University of East Anglia. RCUK Fellow 2011 to 2012 Lecturer 2012 to 2013 Senior Lecturer 2013 to 2016 Reader 2016 onwards Professor of Molecular Microbiology

研究领域

Analysis and rewiring of conserved and essential signal tranduction pathways in Streptomyces bacteria to activate antibiotic production. Developing synthetic biology tools to unlock and discover new antibiotics in filamentous actinomycetes. Understanding how nitric oxide gas acts as a signal to trigger cell division and antibiotic production in Streptomyces species. Understanding the formation or protective symbioses between plant roots and Streptomyces bacteria. Understanding microbiome formation using leafcutter ants as a model.

近期论文

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Crack, J., Hutchings, M., Thomson, A., Le Brun, N.(2016)Biochemical properties of Paracoccus denitrificans FnrP: Reactions with molecular oxygen and nitric oxidein JBIC Journal of Biological Inorganic Chemistry21.pp. 71-82 Full Text UEA Repository(Article) Crack, J., Svistunenko, D. A., Munnoch, J., Thomson, A., Hutchings, M., Le Brun, N.(2016)Differentiated, promoter-specific response of [4Fe-4S] NsrR DNA-binding to reaction with nitric oxidein Journal of Biological Chemistry291.pp. 8663-8672 Full Text UEA Repository(Article) Munnoch, J. T., Widdick, D. A., Chandra, G., Sutcliffe, I. C., Palmer, T., Hutchings, M. I.(2016)Cosmid based mutagenesis causes genetic instability in Streptomyces coelicolor, as shown by targeting of the lipoprotein signal peptidase genein Scientific Reports6. Full Text UEA Repository(Article) Munnoch, J. T., Pellicer Martinez, M. T., Svistunenko, D. A., Crack, J. C., Le Brun, N. E., Hutchings, M. I.(2016)Characterization of a putative NsrR homologue in Streptomyces venezuelae reveals a new member of the Rrf2 superfamilyin Scientific Reports6. Full Text UEA Repository(Article) Crack, J., Munnoch, J. T., Dodd, E., Knowles, F., Al-Bassam, M., Kamali, S., Holland, A., Cramer, S., Hamilton, C., Johnson, M., Thomson, A., Hutchings, M., Le Brun, N.(2015)NsrR from Streptomyces coelicolor Is a Nitric Oxide-sensing [4Fe-4S] Cluster Protein with a Specialized Regulatory Functionin The Journal of Biological Chemistry290.pp. 12689-12704 Full Text UEA Repository(Article) Seipke, R. F., Patrick, E., Hutchings, M. I., Hutchings, M.(2014)Regulation of antimycin biosynthesis by the orphan ECF RNA polymerase sigma factor σ (AntA.)in PeerJ2.pp. e253 Full Text UEA Repository(Article) Gao, H., Grüschow, S., Barke, J., Seipke, R. F., Hill, L. M., Orivel, J., Yu, D. W., Hutchings, M., Goss, R. J. M.(2014)Filipins: the first antifungal “weed killers” identified from bacteria isolated from the trap-antin RSC Advances4.pp. 57267-57270 Full Text UEA Repository(Article) Clark, L., Seipke, R., Prieto, P., Willemse, J., van Wezel, G., Hutchings, M., Hoskisson, P.(2013)Mammalian cell entry genes in Streptomyces may provide clues to the evolution of bacterial virulencein Scientific Reports3. Full Text UEA Repository(Article) Seipke, R. F., Hutchings, M. I.(2013)The regulation and biosynthesis of antimycinsin Beilstein Journal of Organic Chemistry9.pp. 2556-2563 Full Text UEA Repository(Article) Seipke, R. F., Barke, J., Heavens, D., Yu, D. W., Hutchings, M. I.(2013)Analysis of the bacterial communities associated with two ant-plant symbiosesin MicrobiologyOpen2.pp. 276-283 Full Text UEA Repository(Article) Crack, J., Green, J., Hutchings, M., Thomson, A., Le Brun, N.(2012)Bacterial iron-sulfur regulatory proteins as biological sensor-switchesin Antioxidants & Redox Signaling17.pp. 1215-1231 Full Text UEA Repository(Article) Seipke, R., Barke, J., Ruiz-Gonzalez, M., Orivel, J., Yu, D., Hutchings, M.(2012)Fungus-growingin Antonie van Leeuwenhoek101.pp. 443-447 Full Text UEA Repository(Article) Willemse, J., Ruban-osmialowska, B., Widdick, D., Celler, K., Hutchings, M. I., Van Wezel, G. P., Palmer, T.(2012)Dynamic Localization of Tat Protein Transport Machinery Components in Streptomyces coelicolorin Journal of Bacteriology194.pp. 6272-6281 Full Text UEA Repository(Article) Sutcliffe, I. C., Harrington, D. J., Hutchings, M. I.(2012)A phylum level analysis reveals lipoprotein biosynthesis to be a fundamental property of bacteriain Protein & Cell3.pp. 163-170 Full Text UEA Repository(Article) Seipke, R., Gruschow, S., Goss, R., Hutchings, M.(2012)Isolating antifungals from fungus-growing ant symbionts using a genome-guided chemistry approachin Methods in Enzymology517.pp. 47-70 Full Text UEA Repository(Article) Moore, J., Bradshaw, E., Seipke, R., Hutchings, M., McArthur (JIC), M.(2012)Use and discovery of chemical elicitors that stimulate biosynthetic gene clusters in Streptomyces bacteriain Methods in Enzymology517.pp. 367-385 Full Text UEA Repository(Article) Seipke, R., Crossman, L., Drou, N., Heavens, D., Bibb, M., Caccamo, M., Hutchings, M.(2011)Draft Genome Sequence of Streptomyces Strain S4, a Symbiont of the Leaf-Cutting Ant Acromyrmex octospinosusin Journal of Bacteriology193.pp. 4270-4271 Full Text UEA Repository(Article) Barke, J., Seipke, R., Yu, D., Hutchings, M.(2011)A mutualistic microbiome: How do fungus-growing ants select their antibiotic-producing bacteria?in Communicative and Integrative Biology4.pp. 41-43 Full Text UEA Repository(Article) Bellota-Anton, C., Munnoch, J., Robb, R., Adamczyk, K., Candelaresi, M., Parker, A., Dixon, R., Hutchings, M.(2011)Spectroscopic analysis of protein Fe-NO complexesin Biochemical Society Transactions39.pp. 1293-1298 UEA Repository(Article) Palmer, T., Hutchings, M.(2011)Protein secretion in StreptomycesAcademic Press UEA Repository(Chapter)