Hemmings, Andrew - University of East Anglia

个人简介

Reader in Structural Biology, University of East Anglia (2002-present) Senior Lecturer, University of East Anglia (2000-2002) Lecturer, University of East Anglia (1994-2000) STA Research Fellow, Tsukuba, Japan (1993-1994) Lecturer, Birkbeck College, London (1989-1993) Cray Research Fellow, Birkbeck College, London (1988-1989) Royal Society Research Fellow, Beijing, China (1987-1988) Ph.D. University of London (1987) B.Sc. Chemistry, University College London (1982)

研究领域

I am interested in the structural basis for the molecular interactions which underpin biological processes. My group employs techniques in structural, molecular and computational biology to study fundamental problems in mechanistic enzymology and molecular recognition. I am particularly interested in the question of bacterial survival (life – respiration and uptake of nutrients, particularly metals; and death – production of cytotoxic proteins). The aim of this research is to provide insights into how the structures of bacterial proteins and their complexes with ligands and substrates (e.g. RNA/DNA, metal ions and sugars) determine the likelihood of survival of the bacterium. The group forms part of the UEA Centre for Molecular and Structural Biochemistry (CMSB) and has particular expertise in studies of metal and cofactor-rich proteins.

近期论文

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Salmon, M., Thimmappa, R. B., Minto, R. E., Melton, R. E., Hughes, R. K., O'Maille, P. E., Hemmings, A. M., Osbourn, A.(2016)A conserved amino acid residue critical for product and substrate specificity in plant triterpene synthasesin Proceedings of the National Academy of Sciences of the United States of America (PNAS)113.pp. E4407–E4414 Full Text UEA Repository(Article) Bradley, J. M., Svistunenko, D. A., Lawson, T. L., Hemmings, A. M., Moore, G. R., Le Brun, N. E.(2015)Three aromatic residues are required for electron transfer during iron mineralization in Bacterioferritinin Angewandte Chemie International Edition127.pp. 14976–14980 Full Text UEA Repository(Article) Etzold, S., Kober, O. I., Mackenzie, D. A., Tailford, L. E., Gunning, A. P., Walshaw, J., Hemmings, A. M., Juge, N.(2014)Structural basis for adaptation of lactobacilli to gastrointestinal mucusin Environmental Microbiology16.pp. 888-903 Full Text UEA Repository(Article) Stentz, R., Osborne, S., Horn, N., Li, A., Hautefort, I., Bongaerts, R., Rouyer, M., Bailey, P., Shears, S., Hemmings, A., Brearley, C. A., Carding, S.(2014)A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gutin Cell Reports6.pp. 646-656 Full Text UEA Repository(Article) Etzold, S., Mackenzie, D. A., Jeffers, F., Walshaw, J., Roos, S., Hemmings, A. M., Juge, N.(2014)Structural and molecular insights into novel surface-exposed mucus adhesins from Lactobacillus reuteri human strains: A novel mucus adhesin from Lactobacillus reuteriin Molecular Microbiology92.pp. 543-556 Full Text UEA Repository(Article) Holmes, N., Walshaw, J., Leggett, R., Thibessard, A., Dalton, K., Gillespie, M., Hemmings, A., Gust, B., Kelemen, G.(2013)Coiled-coil protein Scy is a key component of a multiprotein assembly contrlling polarized growth in Streptomycesin Proceedings of the National Academy of Sciences of the United States of America (PNAS)110.pp. 397-406 UEA Repository(Article) Soond, S. M., Smith, P. G., Wahl, L., Swingler, T. E., Clark, I. M., Hemmings, A. M., Chantry, A.(2013)Novel WWP2 ubiquitin ligase isoforms as potential prognostic markers and molecular targets in cancerin Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease1832.pp. 2127-2135 Full Text UEA Repository(Article) Geisler, K., Hughes, R. K., Sainsbury, F., Lomonossoff, G. P., Rejzek, M., Fairhurst, S., Olsen, C., Motawia, M. S., Melton, R. E., Hemmings, A. M., Bak, S., Osbourn, A.(2013)Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plantsin Proceedings of the National Academy of Sciences of the United States of America (PNAS)110.pp. E3360-E3367 Full Text UEA Repository(Article) Bradley, J., Marritt, S., Kihlken, M., Haynes, K., Hemmings, A., Berks, B., Cheesman, M., Butt, J.(2012)Redox and Chemical Activities of the Hemes in the Sulfur Oxidation Pathway Enzyme SoxAXin Journal of Biological Chemistry287.pp. 40350-40359 Full Text UEA Repository(Article) Lockwood, C., Clarke, T., Butt, J., Hemmings, A., Richardson, D.(2011)Characterization of the active site and calcium binding in cytochromecnitrite reductasesin Biochemical Society Transactions39.pp. 1871-1875 Full Text UEA Repository(Article) Kemp, G., Clarke, T., Marritt, S., Lockwood, C., Poock, S., Hemmings, A., Richardson, D., Cheesman, M., Butt, J.(2010)Kinetic and thermodynamic resolution of the interactions between sulfite and the pentahaem cytochrome NrfA fromEscherichia coliin Biochemical Journal431.pp. 73-80 Full Text UEA Repository(Article) Hearnshaw, S., West, C., Singleton, C., Zhou, L., Kihlken, M., Strange, R., Le Brun, N., Hemmings, A.(2009)A Tetranuclear Cu(I) Cluster in the Metallochaperone Protein CopZin Biochemistry48.pp. 9324-9326 Full Text UEA Repository(Article) MacKenzie, D., Tailford, L., Hemmings, A., Juge, N.(2009)Crystal Structure of a Mucus-binding Protein Repeat Reveals an Unexpected Functional Immunoglobulin Binding Activityin Journal of Biological Chemistry284.pp. 32444-32453 Full Text UEA Repository(Article) Singleton, C., Hearnshaw, S., Zhou, L., Le Brun, N., Hemmings, A.(2009)Mechanistic insights into Cu(I) cluster transfer between the chaperone CopZ and its cognate Cu(I)-transporting P-type ATPase, CopAin Biochemical Journal424.pp. 347-356 Full Text UEA Repository(Article) Caddick, S., Harrison, C., Stavridou, I., Mitchell, J., Hemmings, A., Brearley, C.(2008)Solanum tuberosum inositol phosphate kinase (StlTPK1) displaying inositol phosphate-inositol phosphate and inositol phosphate-ADP phosphotransferase activitiesin FEBS Letters582.pp. 1731-1737 Full Text UEA Repository(Article) Clarke, T., Kemp, G., Van Wonderen, J., Doyle, R., Cole, J., Tovell, N., Cheesman, M., Butt, J., Richardson, D., Hemmings, A.(2008)Role of a conserved gluatmine residue in tuning the catalytic activity of Escherichia coli cytochrome c nitrite reductasein Biochemistry47.pp. 3789-3799 Full Text UEA Repository(Article) Clarke, T., Mills, P., Poock, S., Butt, J., Cheesman, M., Cole, J., Hinton, J., Hemmings, A., Kemp, G., Soderberg, C., Spiro, S., Van Wonderen, J., Richardson, D.(2008)Escherichia coli cytochrome c nitrite reductase NrfAin Methods in Enzymology437.pp. 63-77 Full Text UEA Repository(Article) Clarke, T., Cole, J., Richardson, D., Hemmings, A.(2007)The crystal structure of the pentahaem c-type cytochrome NrfB and characterization of its solution-state interaction with the pentahaem nitrite reductase NrfAin Biochemical Journal406.pp. 19-30 Full Text UEA Repository(Article) Jepson, B., Mohan, S., Clarke, T., Gates, A., Cole, J., Butler, C., Butt, J., Hemmings, A., Richardson, D.(2007)Spectropotentiometric and structural analysis of the periplasmic nitrate reductase from Escherichia coli.in Journal of Biological Chemistry282.pp. 6425-6437 Full Text UEA Repository(Article) Sauve, V., Bruno, S., Berks, B., Hemmings, A.(2007)The SoxYZ complex carries sulfur cycle intermediates on a peptide swinging armin Journal of Biological Chemistry282.pp. 23194-23204 Full Text UEA Repository(Article)