Hajihosseini, Mohammad - University of East Anglia

个人简介

Senior Lecturer in Developmental Neurobiology & Biomedical Sciences - University of East Anglia, Norwich (2003- present) Postdoctoral fellow - University of Birmingham, UK (2001 - 2003) (The Wellcome Trust) Postdoctoral fellow - Imperial Cancer Research Fund (ICRF, now CRUK), Lincoln's Inn Fields, London (1996-2001) (ICRF and Human Frontiers fellowships) Postdoctoral fellow - National Institutes of Neurological Disorders & Stroke (NINDS), National Institutes of Health (NIH) Bethesda, USA, and Pasteur Institute, Paris, France (1994-1996) (The British Trust for Myelin Project) Post-graduate certificate in Higher Education Practice (PGHEP) – University of East Anglia, Norwich Ph.D. - Developmental Neurobiology - National Institute for Medical Research (NIMR), Mill Hill, London (1994) (Medical Research Council Studentship) M.Sc. - Neurological Sciences - University College London, University of London (1990) B.Sc. – Human Biology – King’s College London, University of London (1988)

研究领域

We work to genetically dissect the role/s of Fibroblast Growth Factor (FGF)/ FGF receptor (FGFR) signaling in mammalian organogenesis and stem cell function. In the past we have elucidated some of these roles in the developing craniofacial sutures, axial skeleton, limbs, lungs, genitalia, submandibular glands and the nervous system. Our model organism and research tool is transgenic mice that carry loss- or gain-of-function mutations in FGFs, FGFRs or FGF signaling mediator genes, or allow their conditional deletion or over-expression. In particular, we have used FGFR1 and FGFR2 mutant mice that model two congenital craniosynostosis diseases: Pfeiffer and Apert syndrome. Our current interest is focused on postnatal and adult neurogenesis in the hypothalamus, with relevance to regulation of appetite and energy-expenditure. Our in vivo studies are complimented by in vitro model systems to delineate the role of FGF signaling in progenitor cell growth and differentiation.

近期论文

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Siggers, P., Carré, G., Bogani, D., Warr, N., Wells, S., Hilton, H., Esapa, C., Hajihosseini, M. K., Greenfield, A.(2014)A Novel Mouse Fgfr2 Mutant, Hobbyhorse (hob), Exhibits Complete XY Gonadal Sex Reversalin PLoS ONE9. Full Text UEA Repository(Article) Haan, N., Goodman, T., Najdi-samiei, A., Stratford, C. M., Rice, R., El Agha, E., Bellusci, S., Hajihosseini, M. K.(2013)Fgf10-Expressing Tanycytes Add New Neurons to the Appetite/Energy-Balance Regulating Centers of the Postnatal and Adult Hypothalamusin The Journal of Neuroscience33.pp. 6170-6180 Full Text UEA Repository(Article) Danopoulos, S., Parsa, S., Al Alam, D., Tabatabai, R., Baptista, S., Tiozzo, C., Carraro, G., Wheeler, M., Barreto, G., Braun, T., Li, X., Hajihosseini, M., Bellusci, S.(2013)Transient Inhibition of FGFR2b-Ligands Signaling Leads to Irreversible Loss of Cellular β-Catenin Organization and Signaling in AER during Mouse Limb Developmentin PLoS ONE8. Full Text UEA Repository(Article) Königshoff, M., El Agha, E., Al Alam, D., Carraro, G., MacKenzie, B., Goth, K., De Langhe, S., Voswinckel, R., Hajihosseini, M., Rehan, V., Bellusci, S.(2012)Characterization of a Novel Fibroblast Growth Factor 10 (Fgf10) Knock-In Mouse Line to Target Mesenchymal Progenitors during Embryonic Developmentin PLoS ONE7. Full Text UEA Repository(Article) Swingler, T., Wheeler, G., Carmont, V., Elliott, H., Barter, M., Abu-Elmagd, M., Donell, S., Boot-Handford, R., Hajihosseini, M., Munsterberg, A., Dalmay, T., Young, D., Clark, I.(2012)The expression and function of microRNAs in chondrogenesis and osteoarthritisin Arthritis & Rheumatism64.pp. 1909-1919 Full Text UEA Repository(Article) Wheldon, L., Khodabukus, N., Patey, S., Smith, T., Heath, J., Hajihosseini, M.(2011)Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse modelin Biochemical Journal436.pp. 71-81 Full Text UEA Repository(Article) Swingler, T., Culley, K., Nicolas, F., Soond, S., Abu-Elmagd, M., Boot-Handford, R., Young, D., Chantry, A., Munsterberg, A., Hajihosseini, M.(2010)066 Identification and Characterisation of Micrornas Involved in Chondrocyte Differentiation and Osteoarthritis Full Text()Garcia-Morales, C., Liu, C., Abu-Elmagd, M., Hajihosseini, M., Wheeler, G.(2009)Frizzled-10 promotes sensory neuron development in Xenopus embryosin Developmental Biology335.pp. 143-155 Full Text UEA Repository(Article) Hajihosseini, M., Duarte, R., Pegrum, J., Donjacour, A., Lana-Elola, E., Rice, D., Sharpe, J., Dickson, C.(2009)Evidence that Fgf10 contributes to the skeletal and visceral defects of an Apert syndrome mouse modelin Developmental Dynamics238.pp. 376-385 Full Text UEA Repository(Article) Redshaw, N., Wheeler, G., Hajihosseini, M., Dalmay, T.(2009)microRNA-449 is a putative regulator of choroid plexus development and functionin Brain Research1250.pp. 20-26 Full Text UEA Repository(Article) Tiozzo, C., Langhe, S. D., Carraro, G., Alam, D. A., Nagy, A., Wigfall, C., Hajihosseini, M., Warburton, D., Minoo, P., Bellusci, S.(2009)Fibroblast Growth Factor 10 Plays a Causative Role in the Tracheal Cartilage Defects in a Mouse Model of Apert Syndromein Pediatric Research66.pp. 386-390 Full Text UEA Repository(Article) Hajihosseini, M., De Langhe, S., Lana-Elola, E., Morrison, H., Sparshott, N., Kelly, R., Sharpe, J., Rice, D., Bellusci, S.(2008)Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesisin Molecular and Cellular Neuroscience37.pp. 857-868 Full Text UEA Repository(Article) De Langhe, S., Carraro, G., Li, C., Tefft, D., Xu, X., Chai, Y., Minoo, P., Hajihosseini, M., Drouin, J., Kaartinen, V., Bellusci, S.(2008)Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signalingin PLoS ONE3. Full Text UEA Repository(Article) Hajihosseini, M.(2008)FGF Signalling in cranial suture development and pathogenesisFront Oral Biol, Basel, Kargerpp. 160-177 UEA Repository(Chapter)De Langhe, S., Carraro, G., Warburton, D., Hajihosseini, M., Bellusci, S.(2006)Levels of mesenchymal FGFR2 signalling modulate smooth muscle progenitor cell commitment in the lung.in Developmental Biology299.pp. 52-62 Full Text UEA Repository(Article) Tuddenham, L., Wheeler, G., Ntouniafousara, S., Waters, J., Hajihosseini, M., Clark, I., Dalmay, T.(2006)The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cellsin FEBS Letters580.pp. 4214-4217 Full Text UEA Repository(Article) Jaskoll, T., Abichaker, G., Witcher, D., Sala, F., Bellusci, S., Hajihosseini, M., Melnick, M.(2005)FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesisin BMC Developmental Biology5. Full Text UEA Repository(Article) Hajihosseini, M., Lalioti, M., Arthaud, S., Burgar, R., Brown, J., Twigg, S., Wilkie, A., Heath, J.(2004)Skeletal development is regulated by fibroblast growth factor receptor 1 signalling.in Development113.pp. 325-335 Full Text UEA Repository(Article) Satoh, Y., Haraguchi, R., Wright, T., Mansour, S., Partanen, J., Hajihosseini, M., Eswarakumar, V., Lonai, P., Yamada, G.(2004)Regulation of external genitalia development by concerted action of FGF ligands and FGF receptors.in Anatomy and Embryology208.pp. 479-486 Full Text UEA Repository(Article) Hajihosseini, M., Heath, J.(2002)Expression patterns of fibroblast growth factors-18 and -20 in mouse embryos is suggestive of novel roles in calvarial and limb development.in Mechanisms of Development113.pp. 79-83 Full Text UEA Repository(Article)