Ellis, Vince - University of East Anglia - School of Biological Sciences

个人简介

Professor of Biochemistry, University of East Anglia (2007-present) Reader, University of East Anglia (2001-2007) British Heart Foundation Senior Research Fellow, University of East Anglia (2000-2006) Honorary Senior Lecturer, Thrombosis Research Institute, London (1995-2000) Danish Cancer Society Senior Research Fellow, University of Copenhagen (1989-1994) Honorary Lecturer, King's College School of Medicine, London (1987-1989) Research Assistant/Research Fellow, King's College School of Medicine, London (1979-1986) Ph.D. - Biochemistry, University of London (1984) B.Sc. - Biochemistry, University of Liverpool (1978)

研究领域

My laboratory is investigating the mechanisms underlying the regulation of serine protease activity and function in pericellular proteolysis, with emphasis on the plasminogen activation system and type-II transmembrane serine protease. The aim of this research programme is to understand at the molecular level how the activity of these powerful proteolytic systems are controlled and how they becomes deregulated in various diseases, in particular those of the cardiovascular system.

近期论文

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Gray, K., Elghadban, S., Thongyoo, P., Owen, K. A., Szabo, R., Bugge, T. H., Tate, E. W., Leatherbarrow, R. J., Ellis, V.(2014)Potent and specific inhibition of the biological activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-IIin Thrombosis and Haemostasis112. Full Text UEA Repository(Article) Ellis, V.(2012)Matrix Proteases in Health and Disease: BEHRENDT:MATRIX PROTEASES O-BKWiley-VCH Verlag GmbH & Co. KGaAISBN 9783527329915 Full Text UEA Repository(Book)Roy, S., Bingle, L., Marshall, J. F., Bass, R., Ellis, V., Speight, P. M., Whawell, S. A.(2011)The role of α9β1 integrin in modulating epithelial cell behaviour: α9β1 integrin and epithelial cell behaviourin Journal of Oral Pathology and Medicine40.pp. 755-761 Full Text UEA Repository(Article) Owen, K., Qiu, D., Alves, J., Schumacher, A., Kilpatrick, L., Li, J., Harris, J., Ellis, V.(2010)Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPAin Biochemical Journal426.pp. 219-228 Full Text UEA Repository(Article) Ravenhill, L., Wagstaff, L., Edwards, D., Ellis, V., Bass, R.(2010)G-helix of Maspin Mediates Effects on Cell Migration and Adhesionin Journal of Biological Chemistry285.pp. 36285-36292 Full Text UEA Repository(Article) Bass, R., Wagstaff, L., Ravenhill, L., Ellis, V.(2009)Binding of Extracellular Maspin to 1 Integrins Inhibits Vascular Smooth Muscle Cell Migrationin Journal of Biological Chemistry284.pp. 27712-27720 Full Text UEA Repository(Article) Bass, R., Ellis, V.(2009)Regulation of urokinase receptor function and pericellular proteolysis by the integrin α5β1in Thrombosis and Haemostasis101.pp. 954-962 Full Text UEA Repository(Article) Qiu, D., Owen, K., Gray, K., Bass, R., Ellis, V.(2007)Roles and regulation of membrane-associated serine proteasesin Biochemical Society Transactions35.pp. 583-587 Full Text UEA Repository(Article) Kilpatrick, L., Harris, R., Owen, K., Bass, R., Ghorayeb, C., Bar-Or, A., Ellis, V.(2006)Initiation of plasminogen activation on the surface of monocytes expressing the type II transmembrane serine protease matriptase.in Blood108.pp. 2616-2623 Full Text UEA Repository(Article) Bass, R., Ellis, V.(2005)Regulation of uPAR function by the integrin alpha 5 eta 1.in Thrombosis and Haemostasis93.pp. 70 UEA Repository(Article) Bass, R., Werner, F., Odintsova, E., Sugiura, T., Berditchevski, F., Ellis, V.(2005)Regulation of urokinase receptor proteolytic function by the tetraspanin CD82.in Journal of Biological Chemistry280.pp. 14811-14818 Full Text UEA Repository(Article) Gray, K., Ellis, V.(2005)Proteolytic processing of neurotrophin and its effect on vascular smooth muscle cell behaviour.in Thrombosis and Haemostasis93.pp. 98 UEA Repository(Article) Kilpatrick, L., Owen, K., Harris, R., Ellis, V.(2005)Dual roles of the type-II transmembrane serine proteases matriptase and hepsin in the activation of pro-uPA and HGF/SF at the cell surface.in Thrombosis and Haemostasis93.pp. 14 UEA Repository(Article) Riddick, A., Shukla, C., Pennington, C., Bass, R., Nuttall, R., Hogan, A., Sethia, K., Ellis, V., Collins, A., Maitland, N., Ball, R., Edwards, D.(2005)Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues.in British Journal of Cancer92.pp. 2171-2180 Full Text UEA Repository(Article) Dalvi, N., Thomas, G., Marshall, J., Morgan, M., Bass, R., Ellis, V., Speight, P., Whawell, S.(2004)Modulation of the urokinase-type plasminogen activator receptor by the beta 6 integrin subunit.in Biochemical and Biophysical Research Communications317.pp. 92-99 Full Text UEA Repository(Article) Ellis, V.(2004)Urokinase plasminogen activatorISBN 978-0-12-079610-6 UEA Repository(Chapter)Ellis, V.(2003)Plasminogen activation at the cell surface.in Current Topics in Developmental Biology54.pp. 263-312 Full Text UEA Repository(Article) Ellis, V.(2003)Plasminogen activators - structure and function.Kluwer Academic/Plenum Publisherspp. 19-46 UEA Repository(Chapter)Miles, L., Ellis, V.(2003)alpha-enolase comes muscling in on plasminogen activation.in Thrombosis and Haemostasis90.pp. 564-566 UEA Repository(Article) Razzaq, T., Bass, R., Vines, D., Werner, F., Whawell, S., Ellis, V.(2003)Functional regulation of tissue plasminogen activator on the surface of vascular smooth muscle cells by the type-II transmembrane protein p63 (CKAP4).in Journal of Biological Chemistry278.pp. 42679-42685 Full Text UEA Repository(Article)