Poschl, Ernst - University of East Anglia - School of Biological Sciences

个人简介

Studied Biology at the Ludwig-Maximilians Universität in Munich (Germany) and graduated in 1979 (Diploma, Biology). After civil service, worked on my PhD thesis at the Max-Planck Institute for Biochemistry in Martinsried (Germany) in the department of ‘Connective Tissue Research’ of Prof. K. Kühn. The thesis focused on novel genes expressed in cartilage (Supervisor: Prof. P.K. Müller) and was finished in 1984 (Dr. rer.nat.). During a period as research scientist at the Sandoz Science Institute (Vienna, Austria), worked on immunological aspects of pharmacologically relevant cytokines. Thereafter, joined the group of Prof. K. Kühn at the Max-Planck Institute in Martinried and focused on various aspects of the genetics and biology of collagen IV and other extracellular matrix. In a number of collaborations with Prof. R. Timpl these studies were extended to other proteins, like perlecan, nidogens or laminins. Established a research group in the Department of ‘Experimental Medicine I’ (Director Prof. K. vonderMark) at the ‘Nikolaus-Fiebiger Zentrum’, a research centre of the Medical Faculty of the University of Erlangen-Nürnberg (Erlangen, Germany). Continued with the analysis of ECM proteins, but also started new projects focusing on the protein family of the annexins or human diseases (Osteaoarthritis). During this period, I was teaching mainly at the Medical Faculty where also the degree of ‘Habilitation’ (Dr. med.habil.; 1997) was received. Joined the School of Biological Sciences at the University of East Anglia in 2005. Career History 2005-present: Senior Lecturer, University of East Anglia, Norwich, UK 1997-2005: Privatdozent (apl. Prof.), University of Erlangen-Nürnberg, Germany 1997: Habilitation (Dr.med.habil.) Medical Faculty, University of Erlangen-Nürnberg, Germany 1992-1997: Research Scientist/Group leader, University of Erlangen-Nürnberg, Germany 1986-1992: Research Assistant, Max-Planck Institute of Biochemistry, Martinsried, Germany 1985-1986: Research Scientist, Sandoz-Forschungs-Institut, Wien, Austria 1985: Research Assistant, Max Planck Institute of Biochemistry, Martinsried, Germany 1984: Dr.rer.nat. (PhD): Biology, University of München, Germany 1979: Diploma Biology, University of München, Germany

研究领域

The group is interested in three major topics: • The analysis of components of the extracellular matrix and the their biological functions in vivo • The biological functions of the prototype member of the annexin protein family, Annexin A5 • The role of perivascular cells during angiogenesis and regenerative processes in skeletal muscle

近期论文

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Zhou, Z., Pausch, F., Schlötzer-Schrehardt, U., Brachvogel, B., Pöschl, E.(2016)Induction of initial steps of angiogenic differentiation and maturation of endothelial cells by pericytes in vitro and the role of collagen IVin Histochemistry and Cell Biology145.pp. 511-525 Full Text UEA Repository(Article) Pitzler, L., Auler, M., Probst, K., Frie, C., Bergmeier, V., Holzer, T., Belluocio, D., Van der Bergen, J., Etich, J., Ehlen, H., Zhou, Z., Bielke, W., Poschl, E., Paulsson, M., Brachvogel, B.(2016)miR-126-3p promotes matrix-dependent perivascular cell attachment, migration and intercellular interactionin Stem Cells34.pp. 1297-1309 Full Text UEA Repository(Article) Kreft, S., Klatt, A. R., Strassburger, J., Poschl, E., Flower, R. J., Emig, S., Reutlingsperger, C., Brisson, A., Brachvogel, B.(2016)Skin wound repair is not altered in the absence of endogenous AnxA1 or AnxA5, but pharmacological concentrations of AnxA4 and AnxA5 inhibit wound hemostasisin Cells Tissues Organs201.pp. 287-298 Full Text UEA Repository(Article) Grskovic, I., Kutsch, A., Frie, C., Groma, G., Stermann, J., Schlötzer-Schrehardt, U., Niehoff, A., Moss, S., Rosenbaum, S., Poschl, E., Chmielewski, M., Rappl, G., Abken, H., Bateman, J., Cheah, K., Paulsson, M., Brachvogel, B.(2012)Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle-mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 responsein Journal of Bone and Mineral Research27.pp. 2399-412 Full Text UEA Repository(Article) Poschl, E.(2012)Improved methods for detection of β-galactosidase (lacZ) activity in hard tissuein Histochemistry and Cell Biology137.pp. 841-847 Full Text UEA Repository(Article) Ueki, H., Mizushina, T., Laoharatchatathanin, T., Terashima, R., Nishimura, Y., Rieanrakwong, D., Yonezawa, T., Kurusu, S., Hasegawa, Y., Brachvogel, B., Poschl, E., Kawaminami, M.(2012)Loss of maternal annexin A5 increases the likelihood of placental platelet thrombosis and foetal lossin Scientific Reports2.pp. 827 UEA Repository(Article) Bouter, A., Gounou, C., Bérat, R., Tan, S., Gallois, B., Granier, T., d'Estaintot, B., Pöschl, E., Brachvogel, B., Brisson, A.(2011)Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repairin Nature Communications2.pp. 274 Full Text UEA Repository(Article) Rosenbaum, S., Kreft, S., Etich, J., Frie, C., Stermann, J., Grskovic, I., Frey, B., Mielenz, D., Pöschl, E., Gaipl, U., Paulsson, M., Brachvogel, B., Evolution, Molecular(2011)Identification of novel binding partners (annexins) for the cell death signal phosphatidylserine and definition of their recognition motifin Journal of Biological Chemistry286.pp. 5708-16 Full Text UEA Repository(Article) Cooley, L., Handsley, M., Zhou, Z., Lafleur, M., Pennington, C., Thompson, E., Poschl, E., Edwards, D.(2010)Reversible trans-differentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitroin Journal of Cell Science123.pp. 3808-3816 Full Text UEA Repository(Article) Belluoccio, D., Grskovic, I., Niehoff, A., Schlotzer-Schrehardt, U., Rosenbaum, S., Etich, J., Frie, C., Pausch, F., Moss, S., Poschl, E., Bateman, J., Brachvogel, B.(2009)Deficiency of annexins A5 and A6 induces complex changes in the transcriptome of growth plate cartilage but does not inhibit the induction of mineralizationin Journal of Bone and Mineral Research25.pp. 141-153 Full Text UEA Repository(Article) Frey, B., Munoz, L., Pausch, F., Sieber, R., Franz, S., Brachvogel, B., Poschl, E., Schneider, H., Rodel, F., Sauer, R., Fietkau, R., Herrmann, M., Gaipl, U.(2008)The immune reaction against allogeneic necrotic cells is reduced in Annexin A5 knock out mice whose macrophages display an anti-inflammatory phenotypein Journal of Cellular and Molecular Medicine13.pp. 1391-1399 Full Text UEA Repository(Article) Munoz, L., Frey, B., Pausch, F., Baum, W., Mueller, R., Brachvogel, B., Poschl, E., Rodel, F., von der Mark, K., Herrmann, M., Gaipl, U.(2007)The Role of Annexin A5 in the Modulation of the Immune Response Against Dying and Dead Cells Full Text()Brachvogel, B., Pausch, F., Farlie, P., Gaipl, U., Etich, J., Zhou, Z., Cameron, T., von der Mark, K., Bateman, J. F., Pöschl, E., Cells, Cultured, Neovascularization, Physiologic(2007)Isolated Anxa5(+)/Sca-1(+) perivascular cells from mouse meningeal vasculature retain their perivascular phenotype in vitro and in vivoin Experimental Cell Research313.pp. 2730-2743 Full Text UEA Repository(Article) Gaipl, U., Munoz, L., Rodel, F., Pausch, F., Frey, B., Brachvogel, B., von der Mark, K., Poschl, E.(2007)Modulation of the immune system by dying clls an the phosphatidylserine-ligand annexin A5in Autoimmunity40.pp. 254-259 Full Text UEA Repository(Article) Gebhard, S., Hattori, T., Bauer, E., Bosl, M., Schlund, B., Poschl, E., Adam, N., de Crombrugghe, B., von der Mark, K.(2007)BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoterin Histochemistry and Cell Biology127.pp. 183-194 Full Text UEA Repository(Article) Mittag, J., Oehr, W., Heuer, H., Hamalainen, T., Brachvogel, B., Poschl, E., Bauer, K.(2007)Expression and thyroid hormone regulation of annexins in the anterior pituitaryin Journal of Endocrinology195.pp. 385-392 Full Text UEA Repository(Article) Munoz, L., Franz, S., Pausch, F., Furnrohr, B., Sheriff, A., Vogt, B., Kern, P., Baum, W., Stach, C., von Laer, D., Brachvogel, B., Poschl, E., Herrmann, M., Gaipl, U.(2007)The influence on the immunomodulatory effects of dying and dead cells of Annexin Vin Journal of Leukocyte Biology81.pp. 6-14 Full Text UEA Repository(Article) von der Mark, H., Poschl, E., Lanig, H., Sasaki, T., Deutzman, R., von der Mark, K.(2007)Distinct Acidic Clusters and Hydrophobic Residues in the Alternative Splice Domains X1 and X2 of alpha7 Integrins Define Specificity for Laminin Isoformsin Journal of Molecular Biology371.pp. 1188-1203 Full Text UEA Repository(Article) Schmidl, M., Adam, N., Surmann-Schmitt, C., Hattori, T., Stock, M., Dietz, U., Decrombrugghe, B., Poschl, E., von der Mark, K.(2006)Twisted gastrulation modulates BMP- induced collagen II and X expression in chondrocytes in vitro and in vivoin Journal of Biological Chemistry281.pp. 31790-31800 Full Text UEA Repository(Article) Brachvogel, B., Moch, H., Pausch, F., Schlotzer-Schrehardt, U., Hofmann, C., Hallmann, R., von der Mark, K., Winkler, T., Poschl, E.(2005)Perivascular cells expressing annexin A5 define a novel mesenchymal stem cell-like population with the capacity to differentiate into multiple mesenchymal lineages.in Development132.pp. 2657-2668 Full Text UEA Repository(Article)