Robinson, Stephen - University of East Anglia - School of Biological Sciences

个人简介

Studied mouse mammary gland development, differentiation and cancer at the University of California Santa Cruz under Professor Charles Daniel. Attained PhD in 1993. Moved to Massachusetts Institute of Technology to conduct postdoctoral research with Professor Richard Hynes studying leukocyte adhesion and rolling. Moved to the United Kingdom in 2000 to conduct postdoctoral research with Professor Kairbaan Hodivala-Dilke at Cancer Research UK studying the role of endothelial integrins in mediating tumour growth and angiogenesis. Started independent research career in 2011 as a Lecturer and Group Leader at UEA. Career History June 2011 – present. Lecturer in Cell Signalling and Angiogenesis, University of East Anglia, School of Biological Sciences, Norwich Research Park, Norwich, UK. 2000 – May 2011. Postdoctoral Fellow, Cancer Research UK, Cell Adhesion and Disease Lab, Centre of Tumour Biology, QMUL, Bart’s Institute of Cancer, London, UK. 1993 - 2000. Postdoctoral Fellow, Massachusetts Institute of Technology, Boston, USA. Under the tutelage of Dr Richard O Hynes. 1987 - 1993. Graduate Student, University of California, Santa Cruz, CA, USA. Under the tutelage of Dr Charles W Daniel.

研究领域

Angiogenesis is the process by which new blood vessels form from those that already exist. It is essential for normal processes such as wound healing. An imbalance in the process is associated with ageing and with a multitude of human diseases, including cancer. Our research is aimed at determining how different cells and molecules contribute to angiogenesis under both normal and pathological situations. Much of my research to date has focused on the role of alphaVbeta3-integrin in angiogenesis. My work as a postdoctoral fellow in the laboratory of Professor Kairbaan Hodivala-Dilke contributed to the seminal findings that alphaVbeta3-integrin can act as a negative regulator of pathological angiogenesis (L.R. Reynolds et al., Nature Medicine 2002) and that low doses of alphaVbeta3-integrin inhibitors can up-regulate angiogenesis (A. Reynolds et al., Nature Medicine, 2009). Recently I showed also that alphaVbeta3-integrin regulates Neuropilin-1 (NRP1)’s function in angiogenesis (S.D. Robinson et al., Journal of Biological Chemistry, 2009).

近期论文

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Su, X., Esser, A. K., Amend, S. R., Xiang, J., Ross, M. H., Fox, G. C., Kobayashi, T., Steri, V., Roomp, K., Fontana, F., Hurchla, M. A., Knolhoff, B. L., Meyer, M. A., Morgan, E. A., Tomasson, J. C., Novack, J. S., Zou, W., Faccio, R., Novack, D. V., Robinson, S. D., Teitelbaum, S. L., DeNardo, D. G., Schneider, J. G., Weilbaecher, K. N.(2016)Antagonizing integrin beta3 increases immune suppression in cancerin Cancer Research76.pp. 3484-3495 Full Text UEA Repository(Article) Kelwick, R., Wagstaff, L., Decock, J., Roghi, C., Cooley, L. S., Robinson, S. D., Arnold, H., Gavrilovic, J., Jaworski, D. M., Yamamoto, K., Nagase, H., Seubert, B., Krüger, A., Edwards, D. R.(2015)Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15: ADAMTS-15 Inhibits Breast Cancer Cell Migrationin International Journal of Cancer136.pp. E14–E26 Full Text UEA Repository(Article) Decock, J., Hendrickx, W., Thirkettle, S., Gutiérrez-Fernández, A., Robinson, S. D., Edwards, D. R.(2015)Pleiotropic functions of the tumor- and metastasis-suppressing Matrix Metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic micein Breast Cancer Research17. Full Text UEA Repository(Article) Ellison, T. S., Atkinson, S. J., Steri, V., Kirkup, B. M., Preedy, M. E. J., Johnson, R. T., Ruhrberg, C., Edwards, D. R., Schneider, J. G., Weilbaecher, K., Robinson, S. D.(2015)Suppression of β3-integrin in mice triggers a neuropilin-1- dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesisin Disease Models & Mechanisms8.pp. 1105-1119 Full Text UEA Repository(Article) Steri, V., Ellison, T. S., Gontarczyk, A. M., Weilbaecher, K., Schneider, J. G., Edwards, D., Fruttiger, M., Hodivala-Dilke, K. M., Robinson, S. D., Cell Line, Tumor, Endothelium, Vascular, Mice, Inbred C57BL, Neoplasms, Experimental, Neovascularization, Pathologic(2014)Acute depletion of endothelial β3-integrin transiently inhibits tumor growth and angiogenesis in micein Circulation Research114.pp. 79-91 Full Text UEA Repository(Article) Jones, D. T., Lechertier, T., Reynolds, L. E., Mitter, R., Robinson, S., Kirn-Safran, C. B., Hodivala-Dilke, K. M., Robinson, S.(2013)Endogenous ribosomal protein L29 (RPL29): a newly identified regulator of angiogenesis in micein Disease Models & Mechanisms6.pp. 115-24 Full Text UEA Repository(Article) Kostourou, V., Lechertier, T., Reynolds, L., Lees, D., Baker, M., Jones, D., Tavora, B., Ramjuan, A., Birdsey, G., Robinson, S., Parsons, M., Randi, A., Hart, I., Hodivala-Dilke, K.(2013)FAK-heterozygous mice display enhanced tumour angiogenesisin Nature Communications4. Full Text UEA Repository(Article) Baker, M., Reynolds, L., Robinson, S., Lees, D., Parsons, M., Elia, G., Hodivala-Dilke, K.(2013)Stromal Claudin14-heterozygosity, but not deletion, increases tumour blood leakage without affecting tumour growthin PLoS ONE8. Full Text UEA Repository(Article) Baker, M., Robinson, S., Lechertier, T., Barber, P. R., Tavora, B., D'Amico, G., Jones, D. T., Vojnovic, B., Hodivala-Dilke, K., Microscopy, Fluorescence, Microscopy, Phase-Contrast, Neovascularization, Physiologic, Mice, Inbred C57BL(2012)Use of the mouse aortic ring assay to study angiogenesisin Nature Protocols7.pp. 89-104 Full Text UEA Repository(Article) Robinson, S., Hodivala-Dilke, K.(2011)The role of β3-integrins in tumor angiogenesis: context is everythingin Current Opinion in Cell Biology23.pp. 630-637 Full Text UEA Repository(Article) Tavora, B., Batista, S., Reynolds, L., Jadeja, S., Robinson, S., Kostourou, V., Hart, I., Fruttiger, M., Parsons, M., Hodivala-Dilke, K.(2010)Endothelial FAK is required for tumour angiogenesisin EMBO Molecular Medicine2.pp. 516-528 Full Text UEA Repository(Article) da Silva, R., Tavora, B., Robinson, S., Reynolds, L., Szekeres, C., Lamar, J., Batista, S., Kostourou, V., Germain, M., Reynolds, A., Jones, D., Watson, A., Jones, J., Harris, A., Hart, I., Iruela-Arispe, M., DiPersio, C., Kreidberg, J., Hodivala-Dilke, K.(2010)Endothelial α3β1-Integrin Represses Pathological Angiogenesis and Sustains Endothelial-VEGFin American Journal of Pathology177.pp. 1534-1548 Full Text UEA Repository(Article) Reynolds, L., Watson, A., Baker, M., Jones, T., D’Amico, G., Robinson, S., Joffre, C., Garrido-Urbani, S., Rodriguez-Manzaneque, J., Martino-Echarri, E., Aurrand-Lions, M., Sheer, D., Dagna-Bricarelli, F., Nizetic, D., McCabe, C., Turnell, A., Kermorgant, S., Imhof, B., Adams, R., Fisher, E., Tybulewicz, V., Hart, I., Hodivala-Dilke, K.(2010)Tumour angiogenesis is reduced in the Tc1 mouse model of Down’s syndromein Nature465.pp. 813-817 Full Text UEA Repository(Article) Worth, D., Hodivala-Dilke, K., Robinson, S., King, S., Morton, P., Gertler, F., Humphries, M., Parsons, M.(2010)Alpha v 3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migrationin Journal of Cell Biology189.pp. 369-383 Full Text UEA Repository(Article) D'Amico, G., Robinson, S., Germain, M., Reynolds, L., Thomas, G., Elia, G., Saunders, G., Fruttiger, M., Tybulewicz, V., Mavria, G., Hodivala-Dilke, K.(2010)Endothelial-Rac1 is not required for tumor angiogenesis unless αvβ3-integrin is absentin PLoS ONE5. Full Text UEA Repository(Article) Germain, M., De Arcangelis, A., Robinson, S., Baker, M., Tavora, B., D'Amico, G., Silva, R., Kostourou, V., Reynolds, L., Watson, A., Jones, J., Georges-Labouesse, E., Hodivala-Dilke, K.(2010)Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesisin The Journal of Pathology220.pp. 370-381 Full Text UEA Repository(Article) Robinson, S., Reynolds, L., Kostourou, V., Reynolds, A., da Silva, R., Tavora, B., Baker, M., Marshall, J., Hodivala-Dilke, K.(2009)avβ3 Integrin Limits the Contribution of Neuropilin-1 to Vascular Endothelial Growth Factor-induced Angiogenesisin Journal of Biological Chemistry284.pp. 33966-33981 Full Text UEA Repository(Article) D'Amico, G., Jones, D., Nye, E., Sapienza, K., Ramjuan, A., Reynolds, L., Robinson, S., Kostourou, V., Martinez, D., Aubyn, D., Grose, R., Thomas, G., Spencer-Dene, B., Zicha, D., Davies, D., Tybulewicz, V., Hodivala-Dilke, K.(2009)Regulation of lymphatic-blood vessel separation by endothelial Rac1in Development136.pp. 4043-4053 Full Text UEA Repository(Article) Reynolds, A., Hart, I., Watson, A., Welti, J., Silva, R., Robinson, S., Da Violante, G., Gourlaouen, M., Salih, M., Jones, M., Jones, D., Saunders, G., Kostourou, V., Perron-Sierra, F., Norman, J., Tucker, G., Hodivala-Dilke, K.(2009)Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitorsin Nature Medicine15.pp. 392-400 Full Text UEA Repository(Article) Reynolds, L., Conti, F., Silva, R., Robinson, S., Iyer, V., Rudling, R., Cross, B., Nye, E., Hart, I., DiPersio, C., Hodivala-Dilke, K.(2008)α3β1 integrin–controlled Smad7 regulates reepithelialization during wound healing in micein Journal of Clinical Investigation118.pp. 965-974 Full Text UEA Repository(Article)