Clarke, Tom - University of East Anglia - School of Biological Sciences

个人简介

Lecturer, University of East Anglia (2011-present) RCUK research Fellow, University of East Anglia (2006-2011) Senior Research Associate, University of East Anglia (2003-2006) Research Fellow, University of Michigan (2001-2003) Ph.D. John Innes Centre, University of East Anglia (1998-2001) M.Sc. Biomolecular Technology, University of Leicester (1997) B.Sc. Biochemistry, University College London, University of London (1992-1995)

研究领域

My interests lie in the characterisation of enzymes that contain metal cofactors, principally enzymes involved in bacterial respiration. These include soluble cytoplasmic and periplasmic proteins, integral membrane proteins as well as extracellular membrane associated proteins that interact with the environment. In collaboration with colleagues in the Centre for Molecular and Structural Biochemistry, my research combines a broad range of biological, biochemical and biophysical techniques to explore protein-protein interactions, electron transfer between cofactors and the mechanism of enzyme catalysis.

近期论文

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Edwards, M., White, G., Norman, M., Tome-Fernandez, A., Ainsworth, E., Shi, L., Fredrickson, J., Zachara, J., Butt, J., Richardson, D., Clarke, T.(2015)Redox Linked Flavin Sites in Extracellular Decaheme Proteins Involved in Microbe-Mineral Electron Transferin Scientific Reports5. Full Text UEA Repository(Article) Clarke, T., Edwards, M., Gates, A., Hall, A., White, G., Bradley, J., Reardon, C., Shi, L., Beliaev, A., Marshall, M., Wang, Z., Watmough, N., Fredrickson, J., Zachara, J., Butt, J., Richardson, D.(2011)Structure of a bacterial cell surface decaheme electron conduitin Proceedings of the National Academy of Sciences108.pp. 9384-9389 Full Text UEA Repository(Article)