Chantry, Andrew - University of East Anglia - School of Biological Sciences

个人简介

BSc from Birmingham University in 1985, and a PhD from the University of London in 1989. He was a postdoctoral fellow at Oxford University (1989-1991), and then an Alexander vonHumboldt Fellow at the Max-Planck Institute in Martinsried (1991-1993), working in Prof. Axel Ullrich’s laboratory. His first independent research group set up in 1993 at Imperial College made significant contributions to defining novel cellular pathways that regulate cell surface receptor activation and dimerisation. This led to the first evidence that transmembrane receptor kinases have specific intracellular dimerisation domains that are essential for receptor activation. Other studies have led to the identification of important cross-talk regulatory mechanisms between receptor tyrosine kinases and calcium signalling pathways. Following his move to UEA in 2000, he began to define novel links between receptor tyrosine kinases and transforming growth factor-b (TGFb), and was the first to demonstrate pathway integration between cytosolic calcium and signalling molecules known as Smad transcription factors. Recently, he established for the first time novel mechanisms for controlling Smad signalling by reversible ubiquitination, linking HECT E3 ubiquitin ligases and deubiquitinating enzymes to TGFb-dependent tumour outgrowth/metastasis. Career History Senior Lecturer in Cell Biology, University of East Anglia (2000-present) Lecturer, Department of Cancer Medicine, Imperial College (1993-2000) Alexander von Humboldt Fellow, Max-Planck-Institute, Munich (1991-1993) Postdoctoral Fellow, University of Oxford (1989-1991) Ph.D. University of London (1989) B.Sc. Medical Biochemistry, University of Birmingham (1985)

研究领域

At present, his laboratory has a translational and drug discovery focus, and has projects aimed at developing novel therapeutic strategies targeting abnormal TGFb activity in cancer metastasis, leukaemia, osteoarthritis, and fibrotic disease.

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Leivonen, S., Lazaridis, K., Decock, J., Chantry, A., Edwards, D., Kähäri, V.(2013)TGF-β-Elicited Induction of Tissue Inhibitor of Metalloproteinases (TIMP)-3 Expression in Fibroblasts Involves Complex Interplay between Smad3, p38α, and ERK1/2in PLoS ONE8. Full Text UEA Repository(Article) Soond, S. M., Smith, P. G., Wahl, L., Swingler, T. E., Clark, I. M., Hemmings, A. M., Chantry, A.(2013)Novel WWP2 ubiquitin ligase isoforms as potential prognostic markers and molecular targets in cancerin Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease1832.pp. 2127-2135 Full Text UEA Repository(Article) Smith, P. G., Tanaka, H., Chantry, A.(2012)A novel co-operative mechanism linking TGFb and Lyn Kinase activation to imatinib resistance in chronic myeloid leukaemia cellsin Oncotarget3.pp. 518-524 UEA Repository(Article) Soond, S., Chantry, A.(2011)How ubiquitination regulates the TGF-β signalling pathway: New insights and new playersin BioEssays33.pp. 749-758 Full Text UEA Repository(Article) Chantry, A.(2011)WWP2 ubiquitin ligase and its isoforms: New biological insight and promising disease targetsin Cell Cycle10.pp. 2437-2439 Full Text UEA Repository(Article) Cutts, A., Soond, S., Powell, S., Chantry, A.(2011)Early phase TGFβ receptor signalling dynamics stabilised by the deubiquitinase UCH37 promotes cell migratory responsesin International Journal of Biochemistry & Cell Biology43.pp. 604-612 Full Text UEA Repository(Article) Soond, S., Chantry, A.(2011)Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMTin Oncogene30.pp. 2451-2462 Full Text UEA Repository(Article) Swingler, T., Culley, K., Nicolas, F., Soond, S., Abu-Elmagd, M., Boot-Handford, R., Young, D., Chantry, A., Munsterberg, A., Hajihosseini, M.(2010)066 Identification and Characterisation of Micrornas Involved in Chondrocyte Differentiation and Osteoarthritis Full Text()Pais, H., Nicolas, F., Soond, S., Swingler, T., Clark, I., Chantry, A., Moulton, V., Dalmay, T.(2010)Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein levelin RNA16.pp. 489-494 Full Text UEA Repository(Article) Traka, M., Gasper, A., Melchini, A., Bacon, J., Needs, P., Frost, V., Chantry, A., Jones, A., Ortori, C., Barrett, D., Ball, R., Mills, R., Mithen, R.(2008)Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostatein PLoS ONE3. Full Text UEA Repository(Article) Frost, V., Grocott, T., Eccles, M. R., Chantry, A.(2008)Self-Regulated Pax Gene Expression and Modulation by the TGFβ Superfamilyin Critical Reviews in Biochemistry and Molecular Biology43.pp. 371-391 Full Text UEA Repository(Article) Møller, G., Frost, V., Melo, J., Chantry, A.(2007)Upregulation of the TGFbeta signalling pathway by Bcr-Abl: Implications for haemopoietic cell growth and chronic myeloid leukaemia.in FEBS Letters581.pp. 1329-1334 Full Text UEA Repository(Article) Grocott, T., Frost, V., Maillard, M., Johansen, T., Wheeler, G. N., Dawes, L. J., Wormstone, I. M., Chantry, A.(2007)The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoterin Nucleic Acids Research35.pp. 890-901 Full Text UEA Repository(Article) Wicks, S., Grocott, T., Haros, K., Maillard, M., ten Dijke, P., Chantry, A.(2006)Reversible uniquitination regulates the Smad/TGF-beta signalling pathway.in Biochemical Society Transactions34.pp. 761-763 Full Text UEA Repository(Article) Wicks, S., Haros, K., Maillard, M., Song, L., Cohen, R., Dijke, P., Chantry, A.(2005)The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGFbeta signalling.in Oncogene24.pp. 8080-8084 Full Text UEA Repository(Article) Wormstone, I., Tamiya, S., Eldred, J., Lazaridis, K., Chantry, A., Reddan, J., Anderson, I., Duncan, G.(2004)Characterisation of TGF-beta 2 signalling and function in a human lens cell line.in Experimental Eye Research78.pp. 705-714 Full Text UEA Repository(Article) Oksvold, M., Thien, C., Widerberg, J., Chantry, A., Huitfeldt, H., Langdon, W.(2004)UV-radiation-induced internalization of the epidermal growth factor receptor requires distinct serine and tyrosine residues in the cytoplasmic carboxy-terminal domain.in Radiation Research161.pp. 685-691 Full Text UEA Repository(Article) Hall, M., Young, D., Waters, J., Rowan, A., Chantry, A., Edwards, D., Clark, I.(2003)The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1.in Journal of Biological Chemistry278.pp. 10304-10313 Full Text UEA Repository(Article) Oksvold, M., Thien, C., Widerberg, J., Chantry, A., Huitfeldt, H., Langdon, W.(2003)Serine mutations that abrogate ligand-induced uniquitination and internalization of the EGF receptor do not affect c-Cb1 association with the receptor.in Oncogene22.pp. 8509-8518 Full Text UEA Repository(Article) Sweetman, D., Smith, T., Farrell, E., Chantry, A., Munsterberg, A.(2003)The conserved glutamine rich region of chick csal1 and csal3 mediates protein interactions with other spalt family members - implications for Townes-Brocks syndrome.in Journal of Biological Chemistry278.pp. 6560-6566 Full Text UEA Repository(Article)