Butt, Julea - University of East Anglia

个人简介

Julea is Professor of Biophysical Chemistry at UEA. Her research elucidates properties of electron transfer proteins relevant to their roles within living organisms and that underpin their rational use in biotechnologies. A range of methods are employed, from molecular biology through to biophysical characterisation with a particular focus on the application of voltammetric, potentiometric and spectroscopic methods. Previously, Julea pioneered the study of adsorbed electroactive proteins for novel perspectives of their biochemistry with Professor Fraser Armstrong, FRS (University of Oxford). This approach, adopted by groups around the world, has become known as protein-film electrochemistry (PFE). In recognition of her achievements Julea received the inaugural Young Investigator Medal from the British Biophysical Society and a Royal Society Leverhulme Trust Senior Research Fellowship in 2015. Julea contributes to teaching in the Schools of Chemistry and Biological Sciences through lectures, seminars and laboratory classes with a focus on topics in biochemistry, reaction kinetics, spectroscopy, electrochemistry and protein structure. She was Deputy Head of the School of Chemistry (2011-2015), Associate Dean for Post-Graduate Research in the Faculty of Science (2011-2014), Director of the Biochemistry Degree Programmes (2006-2011) and a member of the team that launched the School of Pharmacy at UEA.

研究领域

Julea's research focusses on electron transfer (redox) proteins. A suite of electrochemical and spectroscopic methods are employed to reveal properties of purified proteins and their contributions to cellular function. The information obtained provides greater insight into the cellular roles of the redox proteins and informs their exploitation in biotechnologies. Much of our present work involves the multiheme cytochromes that underpin biogeochemical sulfur and nitrogen cycling and extracellular electron transfer in Shewanella oneidensis. You can read more about these projects below.

近期论文

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Heath, G. R., Li, M., Polignano, I. L., Richens, J., Catucci, G., O'Shea, P., Sadeghi, S. J., Gilardi, G., Butt, J., Jeuken, L. J. C.(2016)Layer-by-Layer Assembly of Supported Lipid Bilayer Poly-l-Lysine Multilayersin Biomacromolecules17.pp. 324-335 Full Text UEA Repository(Article) White, G., Edwards, M., Gomez Perez, L., Richardson, D., Butt, J., Clarke, T.(2016)Mechanisms of Bacterial Extracellular Electron Exchange.ElsevierISBN 978-0-12-804823-8 Full Text UEA Repository(Chapter)Lee, C., Reuillard, B., Sokol, K., Laftsoglou, T., Lockwood, C., Rowe, S., Hwang, E. T., Fontecilla-Camps, J., Jeuken, L., Butt, J., Reisner, E.(2016)A decahaem cytochrome as an electron conduit in protein-enzyme redox processesin Chemical Communications52.pp. 7390-7390 Full Text UEA Repository(Article) Maalcke, W. J., Reimann, J., de Vries, S., Butt, J. N., Dietl, A., Kip, N., Mersdorf, U., Barends, T. R. M., Jetten, M. S. M., Keltjens, J. T., Kartal, B.(2016)Characterization of anammox hydrazine dehydrogenase, a key Nin Journal of Biological Chemistry291.pp. 17077-17092 Full Text UEA Repository(Article) Breuer, M., Rosso, K., Blumberger, J., Butt, J.(2015)Multi-heme Cytochromes in Shewanella oneidensis MR-1: Structures, functions and opportunitiesin Journal of The Royal Society Interface12. Full Text UEA Repository(Article) Lockwood, C., Burlat, B., Cheesman, M., Kern, M., Simon, J., Clarke, T., Richardson, D., Butt, J.(2015)Resolution of Key Roles for the Distal Pocket Histidine in Cytochrome c Nitrite Reductasesin Journal of the American Chemical Society137.pp. 3059–3068 Full Text UEA Repository(Article) Hwang, E. T., Sheikh, K., Orchard, K., Hojo, D., Radu, V., Lee, C., Ainsworth, E., Lockwood, C., Gross, M., Adschiri, T., Reisner, E., Butt, J., Jeuken, L. J. C.(2015)A Decaheme Cytochrome as a Molecular Electron Conduit in Dye-Sensitized Photoanodesin Advanced Functional Materials25.pp. 2308–2315 Full Text UEA Repository(Article) Beckwith, C., Edwards, M., Lawes, M., Shi, L., Butt, J., Richardson, D., Clarke, T.(2015)Characterisation of MtoD from Sideroxydans lithotrophicus: a cytochrome c electron shuttle used in lithoautotrophic growthin Frontiers in Microbiology6. Full Text UEA Repository(Article) Pergolizzi, G., Cominetti, M., Butt, J. N., Field, R. A., Bowater, R., Wagner, G. K.(2015)Base-modified NAD and AMP derivatives and their activity against bacterial DNA ligasesin Organic & Biomolecular Chemistry13.pp. 6380-6398 Full Text UEA Repository(Article) Edwards, M., White, G., Norman, M., Tome-Fernandez, A., Ainsworth, E., Shi, L., Fredrickson, J., Zachara, J., Butt, J., Richardson, D., Clarke, T.(2015)Redox Linked Flavin Sites in Extracellular Decaheme Proteins Involved in Microbe-Mineral Electron Transferin Scientific Reports5. Full Text UEA Repository(Article) Butt, J., Gates, A., Marritt, S., Richardson, D.(2015)Enzyme Film ElectrochemistryWiley-Blackwellpp. 105-120ISBN 978-0-470-57845-2(Chapter (peer-reviewed))Kurth, J. M., Dahl, C., Butt, J. N.(2015)Catalytic Protein Film Electrochemistry Provides a Direct Measure of the Tetrathionate/Thiosulfate Reduction Potentialin Journal of the American Chemical Society137.pp. 13232–13235 Full Text UEA Repository(Article) Maalcke, W. J., Dietl, A., Marritt, S. J., Butt, J. N., Jetten, M. S. M., Keltjens, J. T., Barends, T. R. M., Kartal, B.(2014)Structural basis of biological NO generation by octaheme oxidoreductasesin Journal of Biological Chemistry289.pp. 1228-1242 Full Text UEA Repository(Article) Edwards, M. J., Baiden, N., Johs, A., Tomanicek, S. J., Liang, L., Shi, L., Fredrickson, J. K., Zachara, J. M., Gates, A. J., Butt, J. N., Richardson, D. J., Clarke, T. A.(2014)The X-ray crystal structure of Shewanella oneidensis OmcA reveals new insight at the microbe-mineral interfacein FEBS Letters588.pp. 1886-1890 Full Text UEA Repository(Article) Butt, J.(2014)Explorations of time and electrochemical potential: opportunities for fresh perspectives on signalling proteinsin Biochemical Society Transactions42.pp. 47-51 Full Text UEA Repository(Article) Liu, Y., Wang, Z., Liu, J., Levar, C., Edwards, M., Babauta, J., Kennedy, D., Shi, Z., Bayenal, H., Bond, D. R., Clarke, T., Butt, J., Richardson, D., Rosso, K., Zachara, J., Fredrickson, J., Shi, L.(2014)A trans-outer membrane porin-cytochrome protein complex for extracellular electron transfer by Geobacter sulfurreducens PCAin Environmental Microbiology Reports6.pp. 776-785 Full Text UEA Repository(Article) White, G., Shi, Z., Shi, L., Wang, Z., Dohnalkova, A. C., Marshall, M. J., Fredrickson, J. K., Zachara, J. M., Butt, J., Richardson, D., Clarke, T., cytochrome, mineral respiration(2013)Rapid electron exchange between surface-exposed bacterial cytochromes and Fe(III) minerals.in Proceedings of the National Academy of Sciences of the United States of America (PNAS)110.pp. 6346-6351 Full Text UEA Repository(Article) Richardson, D., Butt, J., Clarke, T.(2013)Controlling electron transfer at the microbe-mineral interfacein Proceedings of the National Academy of Sciences of the United States of America (PNAS)110.pp. 7537-7538 Full Text UEA Repository(Article) Doyle, R., Marritt, S., Gwyer, J., Lowe, T., Cheesman, M., Butt, J., Tikhonova, T., Popov, V.(2013)Contrasting catalytic profiles of multiheme nitrite reductases containing CxxCK heme-binding motifsin JBIC Journal of Biological Inorganic Chemistry18.pp. 655-667 Full Text UEA Repository(Article)