Brearley, Charles - University of East Anglia - School of Biological Sciences

个人简介

Studied Biochemistry at the University of Stirling and took a PhD in plant biochemistry at UCNW, Bangor. Undertook post doctoral work in the field of cryopreservation (Brighton) and inositol phosphate biochemistry (Cambridge). Won a BBSRC Advanced Research Fellowship and spent time at the Max-Planck-Institut für Molekulare Pflanzenphysiologie, Potsdam, Germany. Career History Reader, School of Biological Sciences, UEA (2016 -) Senior Lecturer, School of Biological Sciences, UEA (2009 - 2016) Lecturer, School of Biological Sciences, UEA (2001 - 2008) British Council Visiting Researcher, Max-Planck-Institut für Molekulare Pflanzenphysiologie, Germany (1998) BBSRC Advanced Research Fellow, Dept Plant Sciences, University of Cambridge (1997-2000) Postdoctoral Research Associate, Dept Plant Sciences, University of Cambridge (1990-1997) Postdoctoral Researcher, Dept Pharmacy, Brighton Polytechnic (1986-1989) Ph.D. University of Wales (1986)

研究领域

Research in this laboratory addresses the biochemistry and cell biology of inositol phosphates and the enzmes that interconvert them, commonly in plants but also in animal digestive situations where plant materials are components of animal feed. Our research is aligned closely with the needs of, and supported by, industry. Our expertise in inositol phosphate analysis and biochemistry is applied in a number of fields ranging from germination biology, particularly malting scenarios, to human disease. We are developing novel assays of ligand binding to enzymes of inositol metabolism. Our research exploits the disciplines of enzymology and, with Dr Hemmings (BIO), structural biology. Together, we have solved structures of a number of enzymes of inositol metabolism and have developed powerful probes of enzyme function relevant to inositol phosphate signalling in disease contexts.

近期论文

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Stentz, R., Osborne, S., Horn, N., Li, A., Hautefort, I., Bongaerts, R., Rouyer, M., Bailey, P., Shears, S., Hemmings, A., Brearley, C. A., Carding, S.(2014)A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gutin Cell Reports6.pp. 646-656 Full Text UEA Repository(Article) Estavillo, G., Crisp, P., Pornsiriwong, W., Wirtz, M., Collinge, D., Carrie, C., Giraud, E., Whelan, J., David, P., Javot, H., Brearley, C., Hell, R., Marin, E., Pogson, B.(2011)Evidence for a SAL1-PAP Chloroplast Retrograde Pathway That Functions in Drought and High Light Signaling in Arabidopsisin The Plant Cell23.pp. 3992-4012 Full Text UEA Repository(Article) Gonzalez, B., Banos-Sanza, J., Villatea, M., Brearley, C., Sanz-Aparicio, J.(2010)Inositol 1,3,4,5,6-pentakisphosphate 2-kinase is a distant IPK member with a singular inositide binding site for axial 2-OH recognitionin Proceedings of the National Academy of Sciences107.pp. 9608-9613 Full Text UEA Repository(Article) Nagy, R., Grob, H., Weder, B., Green, P., Klein, M., Frelet, A., Schjoerring, J., Brearley, C., Martinoia, E.(2009)The Arabidopsis ATP-binding cassette protein ATMRP5/ATABCC5 is a high-affinity inositol hexakisphosphate transporter involved in guard cell signaling and phytate storagein Journal of Biological Chemistry284.pp. 33614-33622 Full Text UEA Repository(Article)