Bowater, Richard - University of East Anglia - School of Biological Sciences

个人简介

During my research career I have performed a range of studies that have utilised classical biochemical techniques, biophysical methods of analysis, and molecular biology procedures. My Ph.D. was supervised by Dr. David Trentham, FRS, at the National Institute for Medical Research in Mill Hill, London, UK, where I studied the kinetics of energy transduction in rabbit skeletal muscle. My post-doctoral studies continued the combination of biochemistry and biophysics in the laboratory of Prof. David Lilley, FRS, in the Biochemistry Department of the University of Dundee, Dundee, UK. Studies of unusual DNA structures developed into experiments that were among the first to show that the activity of neighbouring promoters can be coupled through DNA topology. In 1994 I moved to the laboratory of Dr. Robert Wells, at the Institute for Biosciences & Technology, Texas A&M University, Houston, USA. Various projects identified that repeating triplet DNA sequences undergo a high level of genetic instability in bacterial cells, with observations being influenced by strain genotype and, in particular, mutations to DNA repair pathways. From 1996 to 1998 I worked in the laboratory of Dr. Tomas Lindahl, FRS, (winner of the 2015 Nobel Prize in Chemistry, along with Modrich & Sancar) at the Clare Hall laboratories of the Imperial Cancer Research Fund (now Cancer Research UK), South Mimms, UK, where I characterised the interactions of human DNA ligases with other proteins. I arrived at the School of Biological Sciences at UEA in 1998 as a UEA Research Fellow, transferring across to academic staff as a Lecturer in 2002 and Senior Lecturer in 2007. My research group has characterised DNA repair processes from a variety of organisms, feeding into wider interests in mechanisms that influence genome stability. The international reputation of our research is reflected in collaborations with researchers in the USA, Germany, Poland, Czech Republic and India. Career History Reader, School of Biological Sciences, UEA (2016-present) Senior Lecturer, School of Biological Sciences, UEA (2007-2016) Lecturer, School of Biological Sciences, UEA (2002-present) University Research Fellow, School of Biological Sciences, UEA (1998-2002) Postdoctoral Fellow, Imperial Cancer Research Fund, South Mimms, UK (1996-1998) Postdoctoral Fellow, Texas A & M University, USA (1994-1996) Postdoctoral Fellow, University of Dundee, UK (1988-1994) Academic Background Ph.D. - University of London, UK (1989); research undertaken at National Institute for Medical Research, London B.Sc. - Biochemistry, University of Sheffield, UK (1984)

研究领域

Having trained as a biochemist, my research interests have broadened out to encompass methodologies that involve biophysical chemistry, microbiology and molecular biology. More recently, I have even dabbled with bioinformatics and structural biology! The research focus of my group is macromolecular interactions of bacterial DNA repair proteins and we have focused attention on DNA ligases. Our experiments are performed in vitro or in bacterial model organisms.

近期论文

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Smith, A., Ball, S., Bowater, R., Wormstone, I.(2016)PARP-1 inhibition influences the oxidative stress response of the human lensin Redox Biology8.pp. 354-362 Full Text UEA Repository(Article) Cobb, A. M., Larrieu, D., Warren, D. T., Liu, Y., Srivastava, S., Smith, A. J., Bowater, R. P., Jackson, S. P., Shanahan, C. M.(2016)Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradientin Aging Cell Full Text UEA Repository(Article) Pergolizzi, G., Wagner, G. K., Bowater, R. P.(2016)Biochemical and structural characterization of DNA ligases from bacteria and archaeain Bioscience Reports36. Full Text UEA Repository(Article) Cotton, C., Bowater, L., Bowater, R. P.(2016)Microbiology survey shows authors have most to gain from peer reviewin FEMS Microbiology Letters363. Full Text UEA Repository(Article) Bowater, R. P., Gates, A. J.(2015)Nucleotides: Structure and Propertiesin eLS Full Text(Scientific review)Bowater, R., Cobb, A., Pivonkova, H., Havran, L., Fojta, M., Biochemistry, Genetics and Molecular Biology (miscellaneous)(2015)Biophysical and electrochemical studies of protein-nucleic acid interactionsin Monatshefte für Chemie - Chemical Monthly146.pp. 723-739 Full Text UEA Repository(Article) Pergolizzi, G., Cominetti, M., Butt, J. N., Field, R. A., Bowater, R., Wagner, G. K.(2015)Base-modified NAD and AMP derivatives and their activity against bacterial DNA ligasesin Organic & Biomolecular Chemistry13.pp. 6380-6398 Full Text UEA Repository(Article) Bowater, R.(2015)Supercoiled DNA: Structurein eLS Full Text(Scientific review)Kelwick, R., Bowater, L., Yeoman, K. H., Bowater, R. P.(2015)Promoting Microbiology Education Through the iGEM Synthetic Biology Competitionin FEMS Microbiology Letters362. Full Text(Scientific review)Smith, A. J. O., Ball, S. S. R., Manzar, K., Bowater, R. P., Wormstone, I. M.(2015)Ku80 Counters Oxidative Stress-Induced DNA Damage and Cataract Formation in the Human Lensin Investigative Ophthalmology and Visual Science56.pp. 7868-7874 Full Text UEA Repository(Article) Bowater, R., Waller, Z.(2014)DNA Structure Full Text()Stejskalová, E., Horáková, P., Vacek, J., Bowater, R. P., Fojta, M.(2014)Enzyme-linked electrochemical DNA ligation assay using magnetic beadsin Analytical and Bioanalytical Chemistry406.pp. 4129-4136 Full Text UEA Repository(Article) Liu, H., Smith, A. J., Lott, M. C., Bao, Y., Bowater, R. P., Reddan, J. R., Wormstone, I. M.(2013)Sulforaphane Can Protect Lens Cells Against Oxidative Stress: Implications for Cataract Preventionin Investigative Ophthalmology & Visual Science54.pp. 5236-5248 Full Text UEA Repository(Article) Cobb, A. M., Jackson, B. R., Kim, E., Bond, P. L., Bowater, R. P.(2013)Sequence-specific and DNA structure-dependent interactions of Escherichia coli MutS and human p53 with DNAin Analytical Biochemistry442.pp. 51-61 Full Text UEA Repository(Article) Bowater, R., Wood, I., Luisi, B.(2012)From Beads on a String to the Pearls of Regulation: the Structure and Dynamics of Chromatinin Biochemical Society Transactions40.pp. 331-334 Full Text UEA Repository(Article) Howell, L., Bowater, R., O'Connell, M., Reszka, A., Neidle, S., Searcey, M.(2012)Synthesis of Small Molecules Targeting Multiple DNA Structures using Click Chemistryin ChemMedChem7.pp. 792-804 Full Text UEA Repository(Article) Cornea, C., Bowater, L., Bowater, R.(2012)Visualizing Science Fiction and relating it to Science Factin The Biochemist34.pp. 4-8 UEA Repository(Article) Cornea, C., Bowater, L., James, H., Bowater, R.(2012)Using science fiction to teach science factsin The Biochemist34.pp. 15-20 UEA Repository(Article) Wang, L., Eldred, J. A., Sidaway, P., Sanderson, J., Smith, A. J. O., Bowater, R. P., Reddan, J. R., Wormstone, I. M.(2012)Sigma 1 receptor stimulation protects against oxidative damage through suppression of the ER stress responses in the human lensin Mechanisms of Ageing and Development133.pp. 665-674 Full Text UEA Repository(Article) Bowater, L., Bowater, R.(2011)Survival of the Fittestin Microbiology Today38.pp. 126-127 UEA Repository(Article)