Minihane, Anne-Marie - University of East Anglia - Department of Nutrition and Preventive Medicine

个人简介

My research investigates the independent and interactive impact of select dietary components (in particular n-3 fatty acids and flavonoids) and common gene variants on cardio-metabolic health. More recently we have also focussed on age-related cognitive decline and Alzheimer’s disease. APOE represents the maingenotype of interest, focussed on gaining an understanding of the aetiology of genotype-health/disease associations, and the impact of APOE genotype on response to dietary change. Having completed my first degree in Nutrition and Biochemistry at University College Cork (Ireland), I moved to the UK to complete my PhD. I have been based here ever since apart from a one year stay at Auckland Medical School (NZ). I enjoy, the outdoors and sports of all varieties, good food and books, and people and places.

研究领域

Nutrigenetics, Dietary n-3 fatty acids and cardio-metabolic health with a focus on lipoprotein metabolism, vascular function and adipose tissue and liver inflammation Diet and cognitive performance Aetiology of the association between the APOE4 genotype and chronic disease risk Determinants of flavonoid metabolism

近期论文

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Rodriguez-Ramiro, I., Vauzour, D., Minihane, A.(2016)Polyphenols and non-alcoholic fatty liver disease: impact and mechanisms: impact and mechanismsCambridgepp. 47-60ISBN 0029-6651 Full Text(Conference contribution)Hazim, S., Curtis, P. J., Schär, M. Y., Ostertag, L. M., Kay, C. D., Minihane, A., Cassidy, A.(2016)Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trialin The American Journal of Clinical Nutrition103.pp. 694-702 Full Text UEA Repository(Article) Tejera, N., Vauzour, D., Betancor, M. B., Sayanova, O., Usher, S., Cochard, M., Rigby, N., Ruiz-Lopez, N., Menoyo, D., Tocher, D. R., Napier, J. A., Minihane, A. M.(2016)A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in micein Journal of Nutrition146.pp. 227-235 Full Text UEA Repository(Article) Minihane, A. M., Armah, C. K., Miles, E. A., Madden, J. M., Clark, A. B., Caslake, M. J., Packard, C. J., Kofler, B. M., Lietz, G., Curtis, P. J., Mathers, J. C., Williams, C. M., Calder, P. C.(2016)Consumption of Fish Oil Providing Amounts of Eicosapentaenoic cid and Docosahexaenoic Acid That Can Be Obtained from the Diet Reduces Blood Pressure in Adults with Systolic Hypertension: A Retrospective Analysisin Journal of Nutrition146.pp. 516-523 Full Text UEA Repository(Article) Minihane, A.(2016)Impact of Genotype on EPA and DHA Status and Responsiveness to Increased Intakesin Nutrients8. Full Text UEA Repository(Article) Shatwan, I. M., Minihane, A., Williams, C. M., Lovegrove, J. A., Jackson, K. G., Vimaleswaran, K. S.(2016)Impact of Lipoprotein Lipase Gene Polymorphism, S447X, on Postprandial Triacylglycerol and Glucose Response to Sequential Meal Ingestionin International Journal of Molecular Sciences17. Full Text UEA Repository(Article) McManus, S., Tejera, N., Awwad, K., Vauzour, D., Rigby, N., Fleming, I., Cassidy, A., Minihane, A.(2016)Differential effects of EPA vs. DHA on postprandial vascular function and the plasma oxylipin profile in menin The Journal of Lipid Research57.pp. 1720-1727 Full Text UEA Repository(Article) Vauzour, D., Camprubi Robles, M., Miquel-Kergoat, S., Andres-Lacueva, C., Bánáti, D., Barberger-Gateau, P., Bowman, G. L., Caberlotto, L., Clarke, R., Hogervorst, E., Kiliaan, A. J., Lucca, U., Manach, C., Minihane, A., Mitchell, E. S., Perneczky, R., Perry, H., Roussel, A., Schuermans, J., Sijben, J., Spencer, J. P., Thuret, S., van de Rest, O., Vandewoude, M., Wesnes, K., Williams, R. J., Williams, R. S., Ramirez, M.(2016)Nutrition for the ageing brain: towards evidence for an optimal dietin Ageing Research Reviews Full Text(Scientific review)Huebbe, P., Dose, J., Schloesser, A., Campbell, G., Gluer, C., Minihane, A., Baines, J. F., Nebel, A., Rimbach, G.(2015)Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization—Studies in gene-targeted replacement micein Molecular Nutrition & Food Research59.pp. 334-343 Full Text UEA Repository(Article) Vauzour, D., Tejera, N., O'Neill, C., Booz, V., Jude, B., Wolf, I. M., Rigby, N., Silvan, J. M., Curtis, P. J., Cassidy, A., De Pascual-Teresa, S., Rimbach, G., Minihane, A.(2015)Anthocyanins do not influence long-chain n-3 fatty acid status: Studies in cells, rodents and humansin Journal of Nutritional Biochemistry26.pp. 211-218 Full Text UEA Repository(Article) Chouinard-Watkins, R., Conway, V., Minihane, A., Jackson, K., Lovegrove, J., Plourde, M.(2015)Interaction between BMI and APOE genotype is associated with changes in the plasma long chain polyunsaturated fatty acid response to a fish oil supplement in healthy participants: Plasma FA response to DHA in APOE4 carriersin American Journal of Clinical Nutrition102.pp. 505-513 Full Text UEA Repository(Article) Minihane, A., Vinoy, S., Russell, W. R., Baka, A., Roche, H. M., Tuohy, K. M., Teeling, J. L., Blaak, E. E., Fenech, M., Vauzour, D., McArdle, H. J., Kremer, B. H. A., Sterkman, L., Vafeiadou, K., Benedetti, M. M., Williams, C. M., Calder, P. C.(2015)Low-grade inflammation, diet composition and health: Current research evidence and its translationin British Journal of Nutrition114.pp. 999-1012 Full Text UEA Repository(Article) Vimaleswaran, K. S., Minihane, A. M., Li, Y., Gill, R., Lovegrove, J. A., Williams, C. M., Jackson, K. G.(2015)The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adultsin Nutrition & Metabolism12.pp. 7 Full Text UEA Repository(Article) Macready, A. L., George, T. W., Chong, M. F., Alimbetov, D. S., Jin, Y., Vidal, A., Spencer, J. P. E., Kennedy, O. B., Tuohy, K. M., Minihane, A., Gordon, M. H., Lovegrove, J. A., Anti-Inflammatory Agents, Non-Steroidal(2014)Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease-FLAVURS: a randomized controlled trialin American Journal of Clinical Nutrition99.pp. 479-489 Full Text UEA Repository(Article) Welch, A., Macgregor, A., Minihane, A., Skinner, J., Valdes, A. A., Spector, T. D., Cassidy, A.(2014)Dietary Fat and Fatty Acid Profile Are Associated with Indices of Skeletal Muscle Mass in Women Aged 18-79 Yearsin The Journal of Nutrition144.pp. 327-334 Full Text UEA Repository(Article) Bhattacharya, B. S., Sweby, P. K., Minihane, A., Jackson, K. G., Tindall, M. J.(2014)A mathematical model of the sterol regulatory element binding protein 2 cholesterol biosynthesis pathwayin Journal of Theoretical Biology349.pp. 150-62 Full Text UEA Repository(Article) Koutsos, A., Jackson, K. G., Lockyer, S., Carvalho-Wells, A., Minihane, A., Lovegrove, J. A.(2014)Greater impact of dietary fat manipulation than apolipoprotein E genotype on ex vivo cytokine production - insights from the SATgenε studyin Cytokine66.pp. 156-9 Full Text UEA Repository(Article) Gammon, C. S., Minihane, A., Kruger, R., Conlon, C. A., von Hurst, P. R., Jones, B., Stonehouse, W., Cholesterol, HDL, Polymorphism, Genetic(2014)TaqIB polymorphism in the cholesteryl ester transfer protein (CETP) gene influences lipid responses to the consumption of kiwifruit in hypercholesterolaemic menin British Journal of Nutrition111.pp. 1077-84 Full Text UEA Repository(Article) Conway, V., Allard, M., Minihane, A., Jackson, K. G., Lovegrove, J. A., Plourde, M.(2014)Postprandial enrichment of triacylglycerol-rich lipoproteins with omega-3 fatty acids: lack of an interaction with apolipoprotein E genotype?in Lipids in Health and Disease13.pp. 148 Full Text UEA Repository(Article) Minihane, A.(2014)Nutrigenetics and personalised/stratified approaches to the provision of dietary advicein Archives of Public Health72. Full Text UEA Repository(Article)