Tyler, Kevin - University of East Anglia

个人简介

Protozoan parasites cause many of the world's worst diseases and are amongst the greatest sources of suffering and death. Because most are restricted to the developing world, researching the biology of these organisms with a view to deriving effective drugs, vaccines and diagnostics has been long neglected. My research has been focussed on this group of organisms for many years and my group's research investigates the interactions between these organisms and their human host, and whether by elucidating and disrupting these interactions we can provide novel therapies. In the fight against disease, I believe it is important that tomorrow's doctors are able to incorporate understanding and indeed practice of biomedical research into their treatment of disease; to understand the importance of the evidence base for the practice of modern medicine. For this reason at UEA I have worked to introduce a research project into the MBBS syllabus and an intercalated MRes course for those medical students wishing to pursue research actively during their medical careers. I hope to be able to offer an intercalated PhD course to medical students in the future. Career History Research Assistant, Royal Veterinary College 1990-1992 Independent Research Fellow, Northwestern University Medical School 1998-2003 Lecturer, University of East Anglia, 2003-2008 Senior Lecturer, University of East Anglia, 2008-current Academic Background King's College, University of London, The Strand, London, UK. BSc 1990 Immunology and Molecular Biology London School of Hygiene and Tropical Medicine, Keppel St, London, UK. MSc 1993 Applied Molecular Biology of Infectious Disease University of Manchester, Oxford Road, Manchester, UK. PhD 1998 Biochemistry

研究领域

Cellular Microbiology We are investigating the way in which Trypanosoma cruzi is able to manipulate host cardiomyoctes to facilitate invasion and for intercellular survival. Our approach is primarily by real-time fluorescence microscopy of host/fluorescent protein chimaeras and fluorescent probes and by use of molecular and chemical intervention. Trypanosome Cell Biology We are investigating the requirements and mechanism of cytological change in trypanosomes; in particular, the roles of cytoskeleton and membrane rafts. Parasite Virulence We are investigating the evolution of parasite molecules which are associated with host specificity and virulence in a number of parasites.

近期论文

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Steverding, D., Tyler, K. K., Sexton, D. W.(2016)Evaluation of marking of peer-marking in oral presentationin Perspectives on Medical Education5.pp. 103-107 Full Text UEA Repository(Article) Bouzid, M., Elwin, K., Nader, J., Chalmers, R., Hunter, P., Tyler, K.(2016)Novel real-time PCR assays for the specific detection of human infective Cryptosporidium speciesin Virulence7.pp. 395-399 Full Text UEA Repository(Article) Steverding, D., Tyler, K.(2015)Of mice and men: are billions victim to toxoplasma mid control?in Microbiology Today52.pp. 10-13 UEA Repository(Article) McBurney, S., Kelly-Clark, W., Forzan, M., Lawson, B., Tyler, K., Greenwood, S.(2015)Molecular characterization of Trichomonas gallinae isolates recovered from the Canadian Maritime provinces’ wild avifauna reveals the presence of the genotype responsible for the European finch trichomonosis epidemic and additional strainsin Parasitology142.pp. 1053-1062 Full Text UEA Repository(Article) Stoco, P. H., Wagner, G., Talavera-lopez, C., Gerber, A., Zaha, A., Thompson, C. E., Bartholomeu, D. C., Lückemeyer, D. D., Bahia, D., Loreto, E., Prestes, E. B., Lima, F. M., Rodrigues-Luiz, G., Vallejo, G. A., Filho, J. F. D. S., Schenkman, S., Monteiro, K. M., Tyler, K. M., Almeida, L. G. P. D., Ortiz, M. F., Chiurillo, M. A., Moraes, M. H. D., Cunha, O. D. L., Mendonça-Neto, R., Silva, R., Teixeira, S. M. R., Murta, S. M. F., Sincero, T. C. M., Mendes, T. A. D. O., Urmenyi, T. P., Silva, V. G., DaRocha, W. D., Andersson, B., Romanha, Á. J., Steindel, M., Vasconcelos, A. T. R. D., Grisard, E. C., Kissinger, J. C. (ed.)(2014)Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeliin PLoS Neglected Tropical Diseases8. Full Text UEA Repository(Article) Bouzid, M., Hunter, P., McDonald, V., Elwin, K., Chalmers, R. M., Tyler, K.(2013)A new heterogeneous family of telomerically encoded Cryptosporidium proteinsin Evolutionary Applications6.pp. 207-217 Full Text UEA Repository(Article) Butler, C., Wheeler, G., Tyler, K.(2013)Visual discrimination of membrane domains in live cells by widefield microscopySpringer-Verlag Berlin Heidelbergpp. 163-184ISBN 9783642331275 Full Text UEA Repository(Chapter)Butler, C. E., de Carvalho, T. M. U., Grisard, E. C., Field, R. A., Tyler, K.(2013)Trans-sialidase Stimulates Eat Me Response from Epithelial Cellsin Traffic14.pp. 853-869 Full Text UEA Repository(Article) Chi, J. F., Lawson, B., Durrant, C., Beckmann, K., John, S., Alrefaei, A. F., Kirkbride, K., Bell, D. J., Cunningham, A. A., Tyler, K. M.(2013)The finch epidemic strain of Trichomonas gallinae is predominant in British non-passerinesin Parasitology140.pp. 1234-1245 Full Text UEA Repository(Article) Bouzid, M., Hunter, P., Chalmers, R. M., Tyler, K.(2013)Cryptosporidium pathogenicity and virulencein Clinical Microbiology Reviews26.pp. 115-134 Full Text UEA Repository(Article) Machado, F., Tyler, K., Brant, F., Esper, L., Teixeira, M., Tanowitz, H.(2012)Pathogenesis of Chagas disease: time to move onin Frontiers in BiosciencesE4.pp. 1743-1758 UEA Repository(Article) Steverding, D., Tyler, K., Grisard, E.(2012)Delivering on promise? The Impact of Kinetoplastid Genomics on Sleeping Sickness, Chagas Disease and LeishmaniasisSpringer Science + Business Mediapp. 131-143 Full Text UEA Repository(Chapter)Jobe, M., Anwuzia-Iwegbu, C., Banful, A., Bosier, E., Iqbal, M., Jones, K., Lecutier, S. J., Lepper, K., Redmond, M., Ross-Parker, A., Ward, E., Wernham, P., Whidden, E. M., Tyler, K., Steverding, D.(2012)Differential in vitro activity of the DNA topoisomerase inhibitor idarubicin against Trypanosoma rangeli and Trypanosoma cruziin Memórias do Instituto Oswaldo Cruz107.pp. 946-50 UEA Repository(Article) Franzén, O., Talavera-López, C., Ochaya, S., Butler, C., Messenger, L. A., Lewis, M. D., Llewellyn, M. S., Marinkelle, C. J., Tyler, K., Miles, M. A., Andersson, B., DNA, Protozoan(2012)Comparative genomic analysis of human infective Trypanosoma cruzi lineages with the bat-restricted subspecies T. cruzi marinkelleiin BMC Genomics13. Full Text UEA Repository(Article) Butler, C., Tyler, K., Models, Biological(2012)Membrane traffic and synaptic cross-talk during host cell entry by Trypanosoma cruziin Cellular Microbiology14.pp. 1345-1353 Full Text UEA Repository(Article) Lawson, B., Cunningham, A., Chantrey, J., Hughes, L., John, S., Bunbury, N., Bell, D., Tyler, K.(2011)A clonal strain of Trichomonas gallinae is the aetiologic agent of an emerging avian epidemic diseasein Infection, Genetics and Evolution11.pp. 1638-1645 Full Text UEA Repository(Article) Lawson, B., Robinson, R., Neimanis, A., Handeland, K., Isomursu, M., Agren, E., Hamnes, I., Tyler, K., Chantrey, J., Hughes, L., Pennycott, T., Simpson, V., John, S., Peck, K., Toms, M., Bennett, M., Kirkwood, J., Cunningham, A., Communicable Diseases, Emerging(2011)Evidence of spread of the emerging infectious disease, finch trichomonosis, by migrating birdsin EcoHealth8.pp. 143-53 Full Text UEA Repository(Article) Wheeler, G., Tyler, K.(2011)Widefield microscopy for live imaging of lipid domains and membrane dynamicsin BBA - Biomembranes1808.pp. 634-641 Full Text UEA Repository(Article) Yoshida, N., Tyler, K., Llewellyn, M.(2011)Trypanosoma cruzi joins the emerging food-borne parasitesin Trends in Parasitology27.pp. 459-466 UEA Repository(Article) Yoshida, N., Tyler, K., Llewellyn, M. S., Communicable Diseases, Emerging, Intestinal Diseases, Parasitic(2011)Invasion mechanisms among emerging food-borne protozoan parasitesin Trends in Parasitology27.pp. 459-466 Full Text UEA Repository(Article)