Steverding, Dietmar - University of East Anglia

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Steverding, Dietmar Dr 收藏完善纠错
University of East Anglia Department of Medicine
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个人简介

After studying Biology and Chemistry at the University of Marburg, I graduated with a Diploma (1987) which is equivalent to a BSc plus an MSc. I stayed at the University of Marburg to undertake a PhD in Biochemistry entitled “On the Mechanism of Energy Transduction in Biological Membranes – Studies on Isolated and in Liposomes Reconstituted Cytochrome c Oxidase” under the supervision of Professor Bernhard Kadenbach. Part of my PhD work I carried out in the laboratories of Professor Sergio Papa at the Institute of Medical Biochemistry and Chemistry, University of Bari, Italy, and Dr Martin Brand at the Department of Biochemistry, University of Cambridge, United Kingdom. These research visits were sponsored by an EMBO Short Term Fellowship and by the Fonds der Chemischen Industrie, respectively. In 1990 I completed my PhD with distinction. After my PhD I took up a position as Head of Laboratories at the Faculty of Process Engineering, University of Applied Sciences Furtwangen (1990-1991). This job included planning and designing of laboratories for the new founded course in Bioengineering. In 1992, I returned to science and took up a position as a postdoctoral research assistant at the prestigious Max-Planck-Institute for Biology in Tübingen to work with Professor Peter Overath on the transferrin receptor of Trypanosoma brucei. This allowed me to get a Research Group Leader position at the Department of Parasitology, University of Heidelberg (1995-2001). I continued my work on the transferrin receptor of T. brucei and started screening of natural and synthetic compounds for trypanocidal and leishmanicidal activity. During this time I completed my Habilitation in Biochemistry (2000) and was awarded the venia legendi and the title “Privatdozent”. After a short research stay at the Interdisciplinary Research Center, University of Gießen (2001), I took up a position as Lecturer in Parasitology at the School of Biological Sciences, University of Bristol (2001-2004). Here I continued my work on screening of compounds for trypanocidal activity and was promoted to Senior Lecturer in 2003. In 2004 I joined the Norwich Medical School at the University of East Anglia as Lecturer in Biochemistry and Genetics. Ever since I am carrying forward my research on antimicrobial drug screening. In 2008 I was promoted to Senior Lecturer again. Career History Career summary 1987-1990, Graduate Teaching Assistant , Faculty of Chemistry, University of Marburg, Germany 1990-1991, Head of Laboratories, Faculty of Process Engineering, University of Applied Sciences Furtwangen, Germany 1992-1995, Postdoctoral Research Assistant, Department of Membrane Biochemistry, Max-Planck-Institute for Biology Tübingen, Germany 1995-2001, Research Group Leader, Department of Parasitology, University of Heidelberg, Germany 2001, Senior Research Assistant, Interdisciplinary Research Center, University of Gießen, Germany 2001-2004, Lecturer/Senior Lecturer in Parasitology, School of Biological Sciences, University of Bristol, United Kingdom. Academic Background 1981-1987, University of Marburg, Germany, Diploma in Chemistry and Biology (equivalent to B.Sc. plus M.Sc.) 1987-1990, University of Marburg, Germany, Ph.D. in Biochemistry (Distinction) 1995-2000, University of Heidelberg, Germany, Habilitation in Biochemistry (venia legendi) Since 2005, member of the British Society for Parasitology

研究领域

My main research interest in the causative agent of human African trypanosomiasis or sleeping sickness, the protozoan parasite Trypanosoma brucei. One area of interest is the transferrin receptor of bloodstream forms of T. brucei which structure is completely different from that of the mammalian transferrin receptor. Especially, I am interested in the interaction between host transferrin and the trypanosomal transferrin receptor. In particular, I want to determine the epitope of host transferrin that is involved in binding to the trypanosomal transferrin receptor. This will be done by crystallography of the ligand-receptor-complex in collaboration with Professor Changjiang Dong. Knowledge of this epitope will provide information for designing peptides that are able to interfere with the binding of host transferrin to the trypanosomal transferrin receptor and could be the starting point for the development of peptidomimetic inhibitors and non-peptide inhibitors as trypanocidal agents. Another area of interest is the screening of compounds for antimicrobial activity. Especially, I have an interest in the antitrypanosomal activity of cysteine protease, proteasome and topoisomerase inhibitors. Primarily, I am testing natural and synthetic compounds for their trypanocidal and cytotoxic activities using cell culture based assays. These investigations are carried out in collaboration with different partners from all over the world. In addition, I have also an interest in screening compounds for activity against fungal infections (e.g. Candida ssp.). A third area of interest in the diagnosis of neglected tropical diseases. I am particular interested in the development of PCR based methods for diagnosis of trypanosomatid infections (Trypanosoma ssp. andLeishmania ssp.). I am also interested in the diagnosis of helminth infections (Echinococcus ssp.) using immunological methods.

近期论文

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Steverding, D., Sexton, D.W., Wang, X., Gehrke, S.S., Wagner, G.K. & Caffrey, C.R. (2012) Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target. Int. J. Parasitol. 42, 481-488 Steverding, D., Wang, X., Potts, B.C.M. & Palladino, M.A. (2012) Trypanocidal activity of β-lactone-γ-lactam proteasome inhibitors. Planta Med. 78, 131-134 Steverding, D. & Wang, X. (2009) Evaluation of anti-sleeping sickness drugs and topoisomerase inhibitors in combination on Trypanosoma brucei. J. Antimicrob. Chemother. 63, 1293-1295 Deterding, A., Dungey, F.A., Thompson, K.-A. & Steverding, D. (2005) Anti-trypanosomal activities of DNA topoisomerase inhibitors. Acta Trop. 93, 311-316 Becker, S., Franco, J.R., Simarro, P.P., Stich, A., Abel, P.M. & Steverding, D. (2004). Real-time PCR for detection of Trypanosoma brucei in human blood samples. Diagn. Microbiol. Infect. Dis. 50, 193-199 Genn, R.J., Pemberton, A.J., Royle, H.J., Spackman, R.W., Smith, E., Rivett, A.J. & Steverding, D. (2004) Trypanocidal effect of α’,β’-epoxyketones indicates that trypanosomes are particularly sensitive to inhibitors of proteasome trypsin-like activity. Int. J. Antimicrob. Agents 24, 286-289 Nkemgu-Njinkeng, J., Rosenkranz, V., Wink, M. & Steverding, D. (2002) Antitrypanosomal activities of proteasome inhibitors. Antimicrob. Agents Chemother. 46, 2038-2040 Kabiri, M. & Steverding, D. (2000) Studies on the recycling of the transferrin receptor in Trypanosoma brucei using an inducible gene expression system. Eur. J. Biochem. 267, 3309-3314 Fast, B., Kremp, K., Boshart, M. & Steverding, D. (1999) Iron-dependent regulation of transferrin-receptor expression in Trypanosoma brucei. Biochem. J. 342, 691-696 Steverding, D., Stierhof, Y.-D., Fuchs, H., Tauber, R. & Overath P. (1995) Transferrin binding protein complex is the receptor for transferrin uptake in Trypanosoma brucei. J. Cell Biol. 131, 1173-1182 Caffrey, C.R. & Steverding, D. (2008) Recent initiatives and strategies to developing new drugs for tropical parasitic diseases. Expert Opin. Drug Discov., 3, 173-186 Caffrey, C.R., Steverding, D., Swenerton, R.K., Kelly, B., Walshe, D., Debnath, A., Zhou, Y.-M., Doyle, P.S., Fafarman, A.T., Zorn, J.A., Land, K.M., Beauchene, J., Schreiber, K., Moll, H., Ponte-Sucre, A., Schirmeister, T., Saravanamuthu, A., Fairlamb, A.H., Cohen, F.E., McKerrow, J.H., Weisman, J.L. & May, B.C.H. (2007) Bis-acridines as lead anti-parasitic agents: structure activity analysis of a discrete compound library in vitro. Antimicrob. Agents Chemother. 51, 2164-2172 Steverding, D. (2006) On the significance of host antibody response to the Trypanosoma bruceitransferrin receptor during chronic infection. Microbes Infect. 8, 2777-2782 Ginger, M.L., Ngazoa, E., Pereira, C.A., Pullen, T.J., Kabiri, M., Becker, K., Gull, K., & Steverding, D. (2005) Intracellular positioning of isoforms explains an unusually large adenylate kinase gene family in the parasite Trypanosoma brucei. J. Biol. Chem. 280, 11781-11789 Deterding, A., Dungey, F.A., Thompson, K.-A. & Steverding, D. (2005) Anti-trypanosomal activities of DNA topoisomerase inhibitors. Acta Trop. 93, 311-316 Becker, S., Franco, J.R., Simarro, P.P., Stich, A., Abel, P.M. & Steverding, D. (2004) Real-time PCR for detection of Trypanosoma brucei in human blood samples. Diagn. Microbiol. Infect. Dis. 50, 193-199 Genn, R.J., Pemberton, A.J., Royle, H.J., Spackman, R.W., Smith, E., Rivett, A.J. & Steverding, D. (2004) Trypanocidal effect of α’,β’-epoxyketones indicates that trypanosomes are particularly sensitive to inhibitors of proteasome trypsin-like activity. Int. J. Antimicrob. Agents 24, 286-289 Nkemgu-Njinkeng, J., Rosenkranz, V., Wink, M. & Steverding, D. (2002) Antitrypanosomal activities of proteasome inhibitors. Antimicrob. Agents Chemother. 46, 2038-2040 Kabiri, M., & Steverding, D. (2001) Identification of a developmentally regulated iron superoxide dismutase in Trypanosoma brucei. Biochem. J. 360, 173-177 Hofer, A., Steverding, D., Chabes, A., Brun, R. & Thelander, L. (2001) Trypanosoma brucei CTP synthetase: a new target for the treatment of African sleeping sickness Proc. Natl. Acad. Sci. USA 98, 6412-6416

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