Hall, Lindsay - University of East Anglia

个人简介

Lindsay Hall qualified with a BSc (Hons) in Microbiology from the University of Glasgow in 2003. She went on to study for a PhD in Microbiology and Immunology at the Wellcome Trust Sanger Institute under the supervision of Prof Gordon Dougan. Her thesis focused on designing and creating mucosal vaccines against Mycobacterium tuberculosis and characterising mucosal immune responses (specifically Natural Killer, [NK] cells) induced after oral and intranasal immunisations. Her PhD was part funded through the EU sixth framework programme entitled Mucosal Vaccines Against Poverty Related Diseases (MUVAPRED). In 2007 Lindsay took up a postdoctoral position at the Alimentary Pharambiotic Centre, University College Cork in Ireland. During her time in Cork, Lindsay moved into a new mucosal immunology area; focused on intestinal inflammatory disorders. Her research utilised experimental Ulcerative colitis and enteric pathogen models to understand the protective role of early mucosal immune responses (including NK cells) during acute intestinal inflammation. In Cork, Lindsay also started to work on the bacterial communities that inhabit the gut, termed the microbiota. Specifically understanding the role of individual members (i.e. Bifidobacterium) and their products (exopolysaccharide capsules) in modulating the critical commensal-host interaction. She returned to the UK in October 2011 to take up a lecturing and Principle Investigator position within the Norwich Medical School, UEA. With her move to Norwich, Lindsay also took up a Research Leader position at the Institute of Food Research, working within the Gut Health and Food Safety programme. In 2013 Lindsay was awarded a 5 year Wellcome Trust New Investigator Award and is building her research team that studies the role of early life gut microbiota in resistance to enteric (gut) infections. Most recently (August 2014), Lindsay was promoted to senior lecturer in gastrointestinal sciences. Career History 2014-current Senior Lecturer and Research Leader in Gastrointestinal Sciences, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich. 2011-current Research Leader, Institute of Food Research, Norwich Research Park, Norwich. 2011-2014 Lecturer and Research Leader in Gastrointestinal Sciences, Norwich Medical School, University East Anglia, Norwich Research Park, Norwich. 2007 – 2011 Post Doctoral Research Fellow, Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland. 2003 – 2007: Ph.D, University of Cambridge. The Wellcome Trust Sanger Institute, Hinxton, Cambridge. 1999 – 2003: BSc (Hons), Microbiology, University of Glasgow.

研究领域

Microbiota Early life (neonatal) Probiotics Microbiota-epithelium interactions Natural Killer (NK) Cells Ulcerative colitis Gastroenteritis

近期论文

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Forde, P. F., Hall, L., de Kruijf, M., Bourke, M. G., Doddy, T., Sadadcharam, M., Soden, D. M.(2015)Non-viral immune electro-gene therapy induces potent anti-tumour responses and has a curative effect in murine colon adenocarcinoma and melanoma cancer modelsin Gene Therapy22.pp. 29–39 Full Text UEA Repository(Article) Forde, P. F., Hall, L. J., Sadadcharam, M., de Kruijf, M., O’ Sullivan, G. C., Soden, D. M.(2014)Development and characterization of an enhanced nonviral expression vector for electroporation cancer treatmentin Molecular Therapy — Methods & Clinical Development1. Full Text UEA Repository(Article) Forde, P. F., Sadadcharam, M., Hall, L. J., O'Donovan, T. R., de Kruijf, M., Byrne, W. L., O'Sullivan, G. C., Soden, D. M.(2014)Enhancement of electroporation facilitated immunogene therapy via T-reg depletionin Cancer Gene Therapy21.pp. 349-354 Full Text UEA Repository(Article) Hall, L. J., Walshaw, J., Watson, A. J. M.(2014)Gut Microbiome in New-Onset Crohn's Diseasein Gastroenterology147.pp. 932–934 Full Text UEA Repository(Article) Watson, A., Hall, L.(2013)Regulation of host gene expression by gut microbiotain Gastroenterology144.pp. 841-4 UEA Repository(Article) Hall, L., Murphy, C., Quinlan, A., Hurley, G., Shanahan, F., Nally, K., Melgar, S.(2013)Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptorin Mucosal Immunology6.pp. 1016-1026 Full Text UEA Repository(Article) Hall, L., Murphy, C., Hurley, G., Quinlan, A., Shanahan, F., Nally, K., Melgar, S.(2013)Natural Killer cells protect against mucosal and systemic infection with the enteric pathogen Citrobacter rodentiumin Infection and Immunity81.pp. 460-469 Full Text UEA Repository(Article) Williams, J. M., Duckworth, C. A., Watson, A. J. M., Frey, M. R., Miguel, J. C., Burkitt, M. D., Sutton, R., Hughes, K. R., Hall, L. J., Caamaño, J. H., Campbell, B. J., Pritchard, D. M.(2013)A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharidein Disease Models & Mechanisms6.pp. 1388-1399 Full Text UEA Repository(Article) Fanning, S., Hall, L., van Sinderen, D.(2012)Bifidobacterium breve UCC2003 surface exopolysaccharide production is a beneficial trait mediating commensal-host interaction through immune modulation and pathogen protection.in Gut Microbes3.pp. 420-5 Full Text UEA Repository(Article) Fanning, S., Hall, L., Cronin, M., Zomer, A., MacSharry, J., Goulding, D., O'Connell Motherway, M., Shanahan, F., Nally, K., Dougan, G., van Sinderen, D.(2012)Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protectionin Proceedings of the National Academy of Sciences109.pp. 2108-2113 Full Text UEA Repository(Article) Hall, L. J., Watson, A. J. M.(2012)Role of autophagy in NOD2-induced inflammation in Crohn's diseasein Gastroenterology142.pp. 1032-1034 Full Text UEA Repository(Article) Murphy, C., Hall, L., Hurley, G., Quinlan, A., MacSharry, J., Shanahan, F., Nally, K., Melgar, S.(2012)The Sphingosine-1-Phosphate Analogue FTY720 Impairs Mucosal Immunity and Clearance of the Enteric Pathogen Citrobacter rodentiumin Infection and Immunity80.pp. 2712-2723 Full Text UEA Repository(Article) Watson, A. J. M., Hall, L. J., Hughes, K. R.(2012)Cell shedding: old questions answeredin Gastroenterology143.pp. 1389-1391 Full Text UEA Repository(Article) Dougan, G., Goulding, D., Hall, L.(2011)Live Vaccines and Their Role in Modern VaccinologySpringerpp. 3-14ISBN 978-3-0346-0276-1 UEA Repository(Chapter)Jansen, A., Hall, L., Clare, S., Goulding, D., Holt, K., Grant, A., Mastroeni, P., Dougan, G., Kingsley, R.(2011)A Salmonella Typhimurium-Typhi genomic chimera: A murine-typphoid model to study Vi polysaccharide capsule functionin PLoS Pathogens7. Full Text UEA Repository(Article) Hall, L., Clare, S., Dougan, G.(2010)NK cells influence both innate and adaptive immune responses after mucosal immunization with antigen and mucosal adjuvantin Journal of Immunology184.pp. 4327-4337 UEA Repository(Article) Hall, L., Clare, S., Dougan, G.(2010)Probing local innate immune responses after mucosal immunisationin Journal of Immune Based Therapies and Vaccines8. UEA Repository(Article) Hall, L., Faivre, E., Quinlan, A., Shanahan, F., Nally, K., Melgar, S.(2010)Induction and activation of adaptive immune populations during acute and chronic phases of a murine model of experimental colitisin Digestive Diseases and Sciences56.pp. 79-89 UEA Repository(Article) Murphy, C., Moloney, G., Hall, L., Quinlan, A., Faivre, E., Casey, P., Shanahan, F., Melgar, S., Nally, K.(2010)Use of bioluminescence imaging to track neutrophil migration and its inhibition in experimental colitisin Clinical and Experimental Immunology162.pp. 188-196 UEA Repository(Article) Hall, L., Clare, S., Pickard, D., Clark, S., Kelly, D., El Ghany, M., Hale, C., Dietrich, J., Andersen, P., Marsh, P., Dougan, G.(2009)Characterisation of a live Salmonella vaccine stably expressing the Mycobacterium tuberculosis Ag85B-ESAT6 fusion proteinin Vaccine27.pp. 6894-6904 UEA Repository(Article)