Watson, Alastair - University of East Anglia

个人简介

1977 - B.A. (Hons) Cambridge, Medical Science 1980 M.B.B.S. London University 1983 M.R.C.P. 1989 - M.D. Cambridge University 1999 - F.R.C.P. 2003 - F.R.C.P. Edinburgh Studied medicine at the Universities of Cambridge (Corpus Christi College) and London (St Thomas’ Hospital). Qualified in 1980. After junior posts in London, Edinburgh and Stoke on Trent became medical registrar in the King’s Liver Unit with Roger Williams. In 1985 became a research fellow with Michael Farthing in St Bartholomew’s hospital, London. In 1989 obtained a Medical Doctorate on the absorption of short chain fatty acids. Became a post-doctoral fellow with Mark Donowitz and Chip Montrose at Johns Hopkins Medical School (1988-90). In 1990 won a Senior Research Fellow Award from the American Gastroenterology Association and an award for outstanding accomplishment in Postdoctoral Research from the American Physiological Society. Returned to the University of Manchester in 1991 to work with Lord Turnberg on apoptosis in the GI epithelium. In 1992 was awarded The Sir Francis Avery Jones British Society of Gastroenterology Research Medal. Appointed Professor of Medicine at the University of Liverpool in 1998 where he served a number of senior administrative posts including Head of the Division of Gastroenterology and Head of the Department of Medicine. He was an Associate Editor of GUT (2003 – 04) then its Deputy Editor (2005 – 2007). He currently serves on the Council of the British Society of Gastroenterology and in 2010 was appointed as its first Secretary of International Affairs. In 2010 he was appointed the University of East Anglia as its first Professor of Translational Medicine.

研究领域

Inflammatory Bowel Disease Colorectal Cancer Apoptosis Epithelial barrier function and cell shedding

近期论文

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D Moussata, M Goetz, A Gloeckner, M Kerner, B Campbell, A Hoffman, S Biesterfeld, B Flourie, JC Saurin, PR Galle, MF Neurath, *AJM Watson, *R Kiesslich. Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in IBD in vivo. Gut 2011;60:26-33. AJMW corresponding author and joint senior author A. Marchando, Shen L, Graham WV, Edelblum KL, Duckworth CA, Guan Y, Montrose MH, Turner JR, Watson AJM. The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. Gastroenterology 2011 (In press). Watson AJM, Duckworth CA. Gut microbiota control gut permeability through GLP2. Gastroenterology 2010;138(2):779-81. Watson A.J.M. The new “connexin” to the pathogenesis of E.coli diarrhoea. Gut 2010;59:154-155. Watson A.J.M., Collins PD. Treatment of Inflammatory Bowel Disease with genetically engineered bacteria. Gastroenterology 2010;139:685-687. Watson A.J.M., Collins PD. Colon cancer: A civilization disorder. Falk Symposium 176 Digestive Diseases 2011 (In press). Watson A.J.M. Tremelling M. Mucosal gene expression signatures that predict response of Ulcerative Colitis to Infliximab. Gastroenterology 2011 Feb;140(2):729-31 Marchiando AM, Shen L, Graham WV, Weber CR, Schwarz BT, Austin JR, Guan Y, Watson AJM, Montrose MH, and Turner JR. Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. Journal of Cell Biology 2010;189(1):111-26. Heidi K Baumgartner, Julia V Gerasimenko, Christopher Thorne, Pawel Ferdek, Tullio Pozzan, Alexei V Tepikin, Ole H Petersen, Robert Sutton, Alastair J. M. Watson, Oleg V. Gerasimenko.Calcium elevation in mitochondria is the main Ca2+ requirement for mPTP opening. Journal of Biological Chemistry 2009;284(31):20796-803. Ralf Kiesslich, Martin Goetz, Elizabeth M. Angus, Qiuping Hu, Yanfang Guan, Chris Potten, Terry Allen, Markus F. Neurath, Noah F. Shroyer, Marshall H. Montrose, Alastair J.M. Watson. Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy. Gastroenterology 2007;133:1769-78. Alice.J Walmesley, Jehad Zweiri, Stephen E. Christmas, Alastair.J.M Watson. Rofecoxib has different effects on chemokine production in colorectal cancer cells and tumour immune splenocytes. Journal of Immunotherapy 2007;6:614-623. Alice.J Walmesley, Jehad Zweiri, Stephen E. Christmas, Alastair.J.M Watson. Rofecoxib has different effects on chemokine production in colorectal cancer cells and tumour immune splenocytes. Journal of Immunotherapy 2007;6:614-623. Bach SP, Williamson SE, O'Dwyer ST, Potten CS, Watson AJM. Regional localisation of p53-independent apoptosis determines toxicity to 5-fluorouracil and pyrrolidinedithiocarbamate in the murine gut. British Journal of Cancer 2006; 95: 35-41. Bullen TF, Forrest S, Campbell F, Dodson AR, Hershman MJ, Pritchard DM, Turner JR, Montrose MH, Watson AJM. Characterization of epithelial cell shedding from human small intestine. Lab Invest. 2006 Oct;86(10):1052-63. Dekker B, Keen H, Lyons S, Disley L, Hastings D, Reader A, Ottewell P, Watson AJM and Zweit J. MBP-Annexin V Radiolabelled Directly with Iodine-124 can be used to Image Apoptosis In Vivo using PET. Nuclear Medicine and Biology 2005; 32:241-252. Alastair J.M. Watson, Shaoyou Chu, Leah Sieck, Oleg Gerasimenko, Tim Bullen, Fiona Campbell, Michael McKenna, Tracy Rose, and Marshall H. Montrose. Epithelial barrier function in vivo is sustained despite gaps in epithelial layers. Gastroenterology 2005;129:902-912. Gerasimenko JV, Gerasimenko OV, Palejwala A, Tepikin AV, Petersen OH, Watson AJM. Menadione-induced apoptosis: roles of cytosolic Ca2+ elevations and the mitochondrial permeability transition pore. J Cell Science 2002:115;485-497. Marshman E, Ottewell P.D. Potten C.S. and Watson A.J.M. Caspase activation during spontaneous and radiation-induced apoptosis in the murine intestine. J Pathol 2001;195:285-292