Powell, Penny - University of East Anglia

个人简介

2015-present 2007-2015 Senior Lecturer, Norwich Medical School, UEA Lecturer, Norwich Medical School, UEA 1994-2005 Senior Scientist and Group Leader, Institute for Animal Health, Pirbright UK. 1991-1994 Research Assistant Professor, Harvard Medical School, Boston, Massachussetts, USA 1987-1991 Postdoctoral Fellow, Harvard Medical School, Boston, Massachussets, USA 1984-1987 Postdoctoral Fellow, St Louis University Medical School, St Louis, Missouri, USA 1984 PhD Biochemistry, Imperial College, University of London 1980 BSc Biochemistry, Imperial College, University of London. Biography After completing her PhD in biochemistry and genetics in London, Penny moved to Washington University Medical School, St Louis as a postdoc with Bill Sly, to study lysosomal storage diseases and the intracellular trafficking of lysosomal enzymes by the mannose 6-phosphate receptor. As one of the first labs to clone the gene for a lysosomal enzyme, beta-glucuronidase, it was later pivitol in gene replacement therapy for this lysosomal storage disease. She subsequently moved to Harvard Medical School, Boston to the angiogenesis group of Mike Klagsbrun and Judah Folkman to investigate vascular growth factors in development, injury and vascular remodelling during pulmonary hypertension. Then recruited as a Senior Scientist to the Institute for Animal Health, Pirbright, she investigated viral proteins which inhibit inflammatory and innate immune responses during viral infection. Currently at Norwich Medical School, University of East Anglia, she studies innate immune responses to viruses, including interferon signalling, RNA interference, stress and autophagy. This includes state-of-the art tissue engineering to grow mouse intestinal organoids or "mini-guts" in culture from stem cells to investigate responses to viral infection and inflammatory stimuli associated with Crohn’s disease by global transcriptomic and proteomic analysis.

研究领域

Viral evasion of the innate immune response Viral proteins that inhibit interferon, RNA interference and inflammatory pathways Stress responses to viral infection Regulation of the innate immune response by autophagy Autophagy pathways as a barrier to gene delivery into cells Innate immunity in the small intestine Innate signalling during gut differentiation from stem cells into small intestinal crypts Use of next generation sequencing (NGS) to detect anti-viral resistance and small viral RNAs

近期论文

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Wileman, T., Netherton, C., Powell, P.(2016)Virus Factories and Mini-Organelles Generated for Virus ReplicationElsevierpp. 819–827 Full Text(Entry for encyclopedia/dictionary) Nasef, N. A., Mehta, S., Powell, P., Marlow, G., Wileman, T., Ferguson, L. R.(2015)Extracts of Feijoa Inhibit Toll-Like Receptor 2 Signaling and Activate Autophagy Implicating a Role in Dietary Control of IBDin PLoS ONE10. Full Text UEA Repository(Article) Jefferson, M., Whelband, M., Mohorianu, I., Powell, P. P.(2014)The pestivirus N terminal protease N(pro) redistributes to mitochondria and peroxisomes suggesting new sites for regulation of IRF3 by N(pro.)in PLoS ONE9. Full Text UEA Repository(Article) Jefferson, M., Donaszi-ivanov, A., Pollen, S., Dalmay, T., Saalbach, G., Powell, P. P.(2014)Host Factors interacting with the Pestivirus N terminal protease, Npro are Components of the Ribonucleoprotein Complexin Journal of Virology88.pp. 10340-10353 Full Text UEA Repository(Article) Goldspink, D., Gadsby, J., Bellett, G., Keynton, J., Tyrrell, B., Lund, E., Powell, P., Thomas, P., Mogensen, M.(2013)The microtubule end-binding protein EB2 is a central regulator of microtubule reorganisation in apico-basal epithelial differentiationin Journal of Cell Science126.pp. 4000-4014 Full Text UEA Repository(Article) Roberts, R., Al-Jamal, W., Whelband, M., Thomas, P., Jefferson, M., van den Bossche, J., Powell, P. P., Kostarelos, K., Wileman, T.(2013)Autophagy and formation of tubulovesicular autophagosomes provide a barrier against nonviral gene deliveryin Autophagy9.pp. 667-682 Full Text UEA Repository(Article) Zhou, Z., Mogensen, M. M., Powell, P. P., Curry, S., Wileman, T., Microscopy, Fluorescence(2013)Foot-and-mouth disease virus 3C protease induces fragmentation of the Golgi compartment and blocks intra-Golgi transportin Journal of Virology87.pp. 11721-11729 Full Text UEA Repository(Article) Donaszi-Ivanov, A., Mohorianu, I., Dalmay, T., Powell, P. P.(2013)Small RNA analysis in Sindbis virus infected human HEK293 cellsin PLoS ONE8. Full Text UEA Repository(Article) Greatorex, J. S., Page, R. F., Curran, M. D., Digard, P., Enstone, J. E., Wreghitt, T., Powell, P., Sexton, D., Vivancos, R., Nguyen-Van-Tam, J. S., RNA, Viral, Influenza A Virus, H1N1 Subtype(2010)Effectiveness of common household cleaning agents in reducing the viability of human influenza A/H1N1in PLoS ONE5. Full Text UEA Repository(Article) Doceul, V., Charleston, B., Crooke, H., Reid, E., Powell, P., Seago, J.(2008)The Npro product of classical swine fever virus interacts with IkappaBalpha, the NF-kappaB inhibitorin Journal of General Virology89.pp. 1881-1889 Full Text UEA Repository(Article) Tennant, L., Renard, C., Chardon, P., Powell, P.(2007)Regulation of porcine classical and non classical MHC class I expressionin Immunogenetics59.pp. 377-389 UEA Repository(Article) Tennant, L. M., Renard, C., Chardon, P., Powell, P. P., Cells, Cultured, Promoter Regions, Genetic(2007)Regulation of porcine classical and nonclassical MHC class I expressionin Immunogenetics 59.pp. 377-89 Full Text UEA Repository(Article) La Rocca, S., Herbert, R., Crooke, H., Drew, T., Wileman, T., Powell, P.(2005)Loss of interferon regulatory factor 3 in cells infected with classical swine fever virus involves the N-terminal protease, Nproin Journal of Virology79.pp. 7239-7247 UEA Repository(Article) Bensaude, E., Turner, J., Wakeley, P., Sweetman, D., Pardieu, C., Drew, T., Wileman, T., Powell, P.(2004)Classical swine fever virus induces proinflammatory cytokines and tissue factor expression and inhibits apoptosis and interferon synthesis during the establishment of long-term infection of porcine vascular endothelial cellsin Journal of General Virology85.pp. 1029-1037 UEA Repository(Article) Vallee, I., Tait, S., Powell, P.(2001)African swine fever virus infection of procine aortic endothelial cells leads to inhibition of inflammatory responses, activation of the thrombotic state and apoptosisin Journal of Virology75.pp. 10372-10382 UEA Repository(Article)