Ellis, Tom - Imperial College London - Department of Bioengineering

个人简介

Dr Tom Ellis is a senior lecturer leading research in synthetic biology and synthetic genome engineering in the Department of Bioengineering. He has track record in synthetic biology, being author of over 20 publications in synthetic biology including work in Nature Methods, Nature Biotechnology, PNAS and Nature Reviews. He is leader of the UK-funded project to build a synthetic yeast chromosome for the international synthetic yeast project (Sc2.0). He co-leads the teaching of Imperial’s synthetic biology undergraduate module and has won multiple awards for teaching and for supervision of 4 of the UK’s most successful iGEM teams. His research focuses on developing the foundational tools for accelerating, automating and scaling design-led synthetic biology, focusing on research projects in yeast (S. cerevisiae) and E. coli model organisms, as well as industrially relevant microbes such as Acetobacter, Geobacillus and Bacillus.

研究领域

Below are some of the more interesting images related to my work in synthetic biology... even lab work with bacteria and yeast can be colourful and interesting on some days.

近期论文

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Storch M, Casini A, Mackrow B, Ellis T, Baldwin GSet al., 2017, BASIC: A Simple and Accurate Modular DNA Assembly Method., Methods Mol Biol, Vol: 1472, Pages: 79-91 Awan AR, Shaw WM, Ellis T, 2016, Biosynthesis of therapeutic natural products using synthetic biology., Adv Drug Deliv Rev, Vol: 105, Pages: 96-106 Blount BA, Driessen MRM, Ellis T, 2016, GC Preps: Fast and Easy Extraction of Stable Yeast Genomic DNA, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322 Borkowski O, Ceroni F, Stan GB, Ellis Tet al., 2016, Overloaded and stressed: whole-cell considerations for bacterial synthetic biology., Curr Opin Microbiol, Vol: 33, Pages: 123-130 Borkowski O, Gilbert C, Ellis T, 2016, On the record with E. coli DNA, SCIENCE, Vol: 353, Pages: 444-445, ISSN: 0036-8075 Ceroni F, Blount BA, Ellis T, 2016, Sensing the Right Time to Be Productive., Cell Syst, Vol: 3, Pages: 116-117, ISSN: 2405-4712 Ellis T, Cai Y, 2016, Synthetic Biology in Europe., ACS Synth Biol, Vol: 5 Florea M, Hagemann H, Santosa G, Abbott J, Micklem CN, Spencer-Milnes X, Garcia LDA, Paschou D, Lazenbatt C, Kong D, Chughtai H, Jensen K, Freemont PS, Kitney R, Reeve B, Ellis Tet al., 2016, Engineering control of bacterial cellulose production using a genetic toolkit and a new cellulose-producing strain, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 113, Pages: E3431-E3440, ISSN: 0027-8424 Florea M, Reeve B, Abbott J, Freemont PS, Ellis Tet al., 2016, Genome sequence and plasmid transformation of the model high-yield bacterial cellulose producer Gluconacetobacter hansenii ATCC 53582., Scientific Reports, Vol: 6, ISSN: 2045-2322 Reeve B, Martinez-Klimova E, de Jonghe J, Leak DJ, Ellis Tet al., 2016, The Geobacillus Plasmid Set: A Modular Toolkit for Thermophile Engineering., ACS Synth Biol Webb AJ, Kelwick R, Doenhoff MJ, Kylilis N, MacDonald JT, Wen KY, McKeown C, Baldwin G, Ellis T, Jensen K, Freemont PSet al., 2016, A protease-based biosensor for the detection of schistosome cercariae, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322 Bricio C, Liu X, Li X, Rehak M, Ellis T, Smith Cet al., 2015, High-throughput picodroplet-based analysis of biosynthetic libraries, Pages: 709-710 Casini A, Storch M, Baldwin GS, Ellis Tet al., 2015, Bricks and blueprints: methods and standards for DNA assembly, NATURE REVIEWS MOLECULAR CELL BIOLOGY, Vol: 16, Pages: 568-576, ISSN: 1471-0072 Ceroni F, Algar R, Stan G-B, Ellis Tet al., 2015, Quantifying cellular capacity identifies gene expression designs with reduced burden, NATURE METHODS, Vol: 12, Pages: 415-+, ISSN: 1548-7091 Lu M, Williamson N, Boschetti C, Ellis T, Yoshimi T, Tunnacliffe Aet al., 2015, Expression-level dependent perturbation of cell proteostasis and nuclear morphology by aggregation-prone polyglutamine proteins., Biotechnol Bioeng, Vol: 112, Pages: 1883-1892 Pothoulakis G, Ellis T, 2015, Using Spinach aptamer to correlate mRNA and protein levels in Escherichia coli., Methods Enzymol, Vol: 550, Pages: 173-185 Storch M, Casini A, Mackrow B, Fleming T, Trewhitt H, Ellis T, Baldwin GSet al., 2015, BASIC: A New Biopart Assembly Standard for Idempotent Cloning Provides Accurate, Single-Tier DNA Assembly for Synthetic Biology, ACS SYNTHETIC BIOLOGY, Vol: 4, Pages: 781-787, ISSN: 2161-5063 Wright O, Delmans M, Stan G-B, Elis Tet al., 2015, Gene Guard: A Modular Plasnnid System Designed for Biosafety, ACS SYNTHETIC BIOLOGY, Vol: 4, Pages: 307-316, ISSN: 2161-5063 Algar RJR, Ellis T, Stan G-B, 2014, Modelling essential interactions between synthetic genes and their chassis cell, IEEE 53rd Annual Conference on Decision and Control (CDC), Publisher: IEEE, Pages: 5437-5444 Cai Y, Ellis T, 2014, The Sixth International Meeting on synthetic Biology (SB6.0) Special Issue Editorial, ACS SYNTHETIC BIOLOGY, Vol: 3, Pages: 107-107, ISSN: 2161-5063