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个人简介

教育背景: 2005.09 - 2009.07,南京大学,化学,学士 2010.01 - 2015.04,波士顿大学,化学生物学、合成生物学,博士 工作经历: 2015 - 2018,劳伦斯伯克利国家实验室和加州大学伯克利分校,博士后 2018 - 至今,武汉大学化学与分子科学学院,教授、博士生导师 获奖荣誉: 国家海外高层次人才引进计划,湖北省高层次人才,“3551 光谷人才计划”,入选 “南鄂英才计划”

研究领域

化学生物学,合成生物学,天然产物药物,生物工程

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Zhuo-Kun Chen, Shuo Zheng, Yan Long, Kui-Ming Wang, Bo-Lin Xiao, Jin-Bang Li, Wei Zhang*, Heng Song,* and Gang Chen*, High-throughput screening identifies ibuprofen as an sEV PD-L1 inhibitor for synergistic cancer immunotherapy, Molecular Therapy, 2024, 32, 3580-3596. 2. Shuo Zheng, Xinlei Xu, Tian Gao, and Heng Song*, One-Pot Microbial Cell Factory Strategy for the Production of Protocatechuic Acid from Polyethylene Terephthalate Waste, ACS Sustainable Chemistry&Engineering, 2024, 12, 5632-5639. 3. Weihua Wang, Chu Han, Shengjie Xie, Zisong Cong, Zixuan Yang, Yuxin Feng, Limin Xiang,and Heng Song*,A High-Contrast Autolysosome Probe for Detecting Interactionbetween Autophagosomes and Autolysosomes in Mitophagy, Chinese Journal of Chemistry, 2024, 42, 858-866. 4. Xinying Ge#, Yan Long#, Jun Wang#, Bo Gu, Zixuan Yang, Yinyin Feng, Shuo Zheng, Yingying Li, Wupeng Yan* and Heng Song*,Regulation of P450 TleB catalytic flow for the synthesis of sulfur-containing indole alkaloids by substrate structure-directed strategy and protein engineering,Science China Chemistry, 2023, 66. 5. Shengbo Li, Xuemei Wang, Zhiyao Yan, Tian Wang, Zhenbing Chen, Heng Song* and Yongbin Zheng*, Microneedle Patches with Antimicrobial and Immunomodulating Properties for Infected Wound Healing, Advanced Science, 2023, 2300576. 6. Shengjie Xie, Zisong Cong, Weihua Wang, Shanshan Qin, Xiaocheng Weng*, Heng Song*, Xiang Zhou, Mitochondria-targeting NIR AIEgens with cationic amphiphilic chaacter for imaging and efficient photodynamic therapy, Chemical Communication, 2023, 59, 2592. 7. Zhiqin Xu, Yaling Mo, Zhengwen Li, Shurong Ban* and Heng Song*, New small-molecule alcohol synthesis by breaking the space limitation of the “aromatic cage”in Pseudomonas sp. AK1 BBOX, Organic Biomolecular Chemistry, 2023, 21, 6397–6404 8. Zhen Q. Wang#, Heng Song#(共同一作), Edward J. Koleski, Noritaka Hara, Dae Sung Park, Gaurav Kumar, Yejin Min, Paul J. Dauenhauer and Michelle C. Y. Chang*,A dual cellular–heterogeneous catalyst strategy for the production of olefins from glucose,Nature Chemistry, 2021, 13, 1178–1185. 9. Zhuoran Jiang, Chao Wang, Zixin Wu, Kun Chen, Wei Yang, Hexiang Deng*, Heng Song* and Xiang Zhou*, Enzymatic deamination of the epigenetic nucleoside N6-methyladenosine regulates gene expression, Nucleic Acids Research, 2021, 49, 12049-12069. 10. Yunbin Wu, Rui Xu, Yuxin Feng, Heng Song*, Rational Design of a De Novo Enzyme Cascade for Scalable Continuous Production of Antidepressant Prodrugs, ACS Catalysis, 2022, 12, 3767-3775. 11. Yan Long#, Shuo Zheng#, Yuxin Feng, Zixuan Yang, Xinlei Xu, and Heng Song*, Kinetic Solvent Isotope Effect in P450-Mediated Cyclization in Indolactams: Evidence for Branched Reactions and Guide for Their Modulation in Heterocycle Chemoenzymatic Synthesis, ACS Catalysis, 2022, 12, 9857-9863. 12. Xuemei Wang#, Shengbo Li#, Siqi Wang, Shuo Zheng, Zhenbing Chen*, Heng Song*, Protein Binding Nanoparticles as an Integrated Platform for Cancer Diagnosis and Treatment, Advanced Science, 2022, 2202453. 13. Zisong Cong#, Shengjie Xie#, Zhuoran Jiang, Shuo Zheng, Weihua Wang, Wenyan Wang and Heng Song*, In vivo photodynamic therapy based on Near-Infrared AIE cationic polymers, Chemical Engineering Journal, 2022, 431, 133748. 14. Jie Wang#, Zhuoran Jiang#, Yurong Wei#, Wenjie Wang, Fubing Wang, Yanbing Yang*, Heng Song*, and Quan Yuan*, Multiplexed identification of bacterial biofilm infections based on machine-learning-aided lanthanide encoding, ACS Nano, 2022, 16, 2, 3300–3310. 15. Wenyan Wang, Shuo Zheng, Yinhui Hong, Xinlei Xu, Xiang Feng, and Heng Song*, Hydrogel-metal-organic-framework nanoparticle composites for immobilization of active biomacromolecules, ACS Applied Nano Materials. 2022, 5, 2, 2222–2230. 16. Shengbo Li#, Xuemei Wang#, Jing Chen, Jiahe Guo, Meng Yuan, Gui Wan, Chengqi Yan, Wenqing Li, Hans-Günther Machens,Yuval Rinkevich, XiaofanYang*, Heng Song* and Zhenbing Chen*, Calcium ion cross-linked sodium alginate hydrogels containing deferoxamine and copper nanoparticles for diabetic wound healing, International Journal of Biological Macromolecules, 2022, 202, 657-670. 17. Yuxin Feng,# Yan Long,# Jiahe Guo,# Xiaofan Yang* and Heng Song*, Redox- and pH-responsive water-soluble flexible organic frameworks realize synergistic tumor photodynamic and chemotherapeutic therapy, Macromolecular Rapid Communications, 2022, DOI: 10.1002/marc.202200690. 18. Siqi Wang, Zisong Cong, Zhiqin Xu, Shurong Ban* and Heng Song*, Fluorescent dyes with multiple quaternary ammonium centers for specific image discrimination and Gram-positive antibacterial activity, Organic & Biomolecular Chemistry. 2022, 20, 3980-3987. 19. Yaxuan Qian#, Zhuoran Jiang#, Yan Long#, Houguo Fei, Heng Song*, Cunlan Guo*, Electro-Enzymatic Aromatic Nitration via Electric Field and Electro-mediator, ACS Sustainable Chemistry&Engineering, 2022, 10, 6667-6674.

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