Brown, Guy - University of Cambridge - Department of Biochemistry

个人简介

Prof. Guy C. Brown received his Ph.D. in 1986 from the Biochemistry Department at Cambridge, then had a College Research Fellowship from St Catharine's College for 3 years. He then moved to the Department of Physiology, University College London, with a Wellcome Trust Post-doctoral Fellowship, and after 18 months transferred to a Royal Society Research Fellowship at the Department of Biochemistry at UCL. In 1994 he returned to Cambridge with the Royal Society Research Fellowship, and is now a Professor of Cellular Biochemistry at the Department of Biochemistry, University of Cambridge. He has published about 150 scientific papers. His research has been funded by: the Medical Research Council, the Biotechnology & Biological Sciences Research Council, the European Union, the Wellcome Trust, the British Heart Foundation, and Alzheimer’s Research UK.

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Neher JJ, Emmrich JV, Fricker M, Mander PK, Thery C, Brown GC (2013) Phagocytosis executes delayed neuronal death after focal brain ischemia. Proc Natl Acad Sci 110:E4098-107. Hornik TC, Neniskyte U & Brown GC (2013) Inflammation induces Multinucleation of Microglia via PKC inhibition of Cytokinesis, generating highly phagocytic Multinucleated Giant Cells. J. Neurochem. In press Emmrich J. Hornik T Neher J & Brown GC (2013) Rotenone induces neuronal death by microglial phagocytosis of neurons. FEBS J. 280, 5030-5038. Fricker M, Vilalta A, Tolkovsky AM, Brown GC (2013) Caspase inhibitors protect neurons by enabling selective necroptosis of inflamed microglia. J Biol Chem. 288, 9145-52. Neniskyte U, Brown GC (2013) Lactadherin/MFG-E8 is essential for microglia-mediated neuronal loss and phagoptosis induced by amyloid β. J Neurochem. 126, 312-7. Brown GC & Neher JJ (2012) Eaten alive! Cell death by primary phagocytosis: ‘phagoptosis’. Trends Biochem. Sci. 37, 325-332. Fricker M, Neher JJ, Zhao JW, Théry C, Tolkovsky AM, Brown GC (2012) MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation. J Neurosci. 32, 2657-66. Fricker M, Oliva-Martin MJ, Brown GC (2012) Primary phagocytosis of viable neurons by microglia activated with LPS or Abeta is dependent on calreticulin/LRP phagocytic signalling. Journal of Neuroinflammation, 13, 9. Neher JJ, Neniskyte U, Zhao ZW, Bal-Price A, Tolkovsky AM & Brown GC (2011) Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death. J Immunol. 186, 4973-83. Barauskaite J, Grybauskiene R, Morkuniene R, Borutaite V, Brown GC (2011) Tetramethylphenylenediamine protects the isolated heart against ischaemia-induced apoptosis and reperfusion-induced necrosis. Br J Pharmacol. 162:1136-42.