Baylis, Howard - University of Cambridge

研究领域

We am aim to understand how signalling within and between cells is used to regulate the physiology and development of animals. In particular we are studying how signalling networks that use the second messengers calcium and inositol 1,4,5-trisphosphate (IP3) are used to control the biology of C. elegans. Our research is always driven by a desire to integrate a mechanistic understanding of cell and molecular processes with whole animal function as revealed and measured by development, physiological function or behaviour. In one current project we are defining the mechanism by which cell signalling pathways regulate RNAi. In another we are dissecting interactions between calcium signalling and presenilins. Presenilins are of particular interest because mutations in human presenilins cause familial Alzheimer’s disease. In addition to this work I have an ongoing interest in collaborating with other laboratories to generate C. elegans models of human disease. To tackle these questions we use a combination of approaches including; RNAi and genetics to perturb and analyse gene function, protein interaction techniques, cell biological and microscopical approaches to address function and assays of whole animal function.

近期论文

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Nagy AI, Vázquez-Manrique RP, Lopez M, Christov C, Sequedo MD, Herzog M, Herlihy AE, Bodak M, Gatsi R and Baylis HA (2015) IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans. EMBO Rep. 16, 341-350. DOI 10.15252/embr.201439585 Baylis H A and Vazquez-Manrique R P (2011) Genetic analysis of IP3 and calcium signalling pathways in C. elegans. Biochim. Biophys. Acta-Gen. Subj. 1820, 1253-1268 DOI: 10.1016/j.bbagen.2011.11.009 Walker D S, Vazquez-Manrique R P, Gower N J D, Gregory E, Schafer W R and Baylis H A (2009) Inositol 1,4,5-trisphosphate signalling regulates the avoidance response to nose touch in Caenorhabditis elegans. PLoS Genet 5(9): e1000636. doi:10.1371/journal.pgen.1000636 Parker S P, Walker D S, Ly S and Baylis H A (2009) Caveolin-2 is required for apical lipid trafficking and suppresses basolateral recycling defects in the intestine of Caenorhabditis elegans. Mol Biol Cell 20, 1763-1771, Kwan C S M, Vazquez-Manrique R P, Ly S, Goyal K and Baylis H A (2008) TRPM channels are required for rhythmicity in the ultradian defecation rhythm of C. elegans. BMC Phys 8:11doi:10.1186/1472-6793-8-11 Vazquez-Manrique R P, Nagy A I, Legg J C, Bales O A M, Ly S and Baylis H A (2008) Phospholipase C-ε Regulates Epidermal Morphogenesis in Caenorhabditis elegans. PLoS Genet 4(3): e1000043. doi:10.1371/journal.pgen.1000043