ZHU, Ye - National University of Singapore - Department of Chemistry, Faculty of Science

个人简介

ACADEMIC QUALIFICATIONS 2006—2012 University of Chicago (Illinois, United States)Ph.D., Chemistry, June 2012 Advisor: Professor Viresh H. Rawal Candidacy committee: Professors Stephen B.H. Kent and Hisashi Yamamoto Dissertation committee: Professors Hisashi Yamamoto and Sergey A. Kozmin Thesis: “Studies on Squaramide-Catalyzed Phospha-Michael Addition and Palladium-Catalyzed Indole Functionalization Reactions” M.S., Chemistry, August 2007 2002—2006 Peking University (Beijing, China) B.S., Chemistry, July 2006 Advisor: Professor Xinsheng Zhao (Department of Chemistry) Thesis: “Nucleic Acid Aptamer Biosensors for Electrochemical Detection of Proteins” Interdisciplinary Research (Principal Research Fund) Advisor: Professor Zhijian Chen (Department of Physics) “Engineered OLED Through Self-assembly Guided by Theoretical Calculation” EMPLOYMENT HISTORY National University of Singapore (Republic of Singapore) Assistant Professor of Chemistry 2018—Present Bristol-Myers Squibb (New Jersey, United States) Senior Research Investigator 2017—2018 Research Investigator II 2014—2017 POSTDOCTORAL EXPERIENCE Massachusetts Institute of Technology (Massachusetts, United States) Postdoctoral Fellow 2012—2014 Advisor: Professor Stephen L. Buchwald

研究领域

Chemical synthesis of biologically relevant molecules remains the rate-limiting step in drug discovery and development despite the tremendous progress that has been made in academia and industry. Our research focuses on inventing and developing enabling chemical tools to address significant synthetic challenges facing biomedical sciences and pharmaceutical industry, thus accelerating creation of potential new medicines. To achieve this goal, our effort is directed towards: Innovating chemo-, regio-, and stereo-selective catalytic reactions that are compatible with polar groups and heterocycles; Designing and developing novel strategies for late-stage functionalization of synthetic scaffolds and natural products; Discovering molecular recognitions between biomolecules and artificial receptors in three-dimensional chemical space.

近期论文

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Ivan Keng Wee On, Wenyang Hong, and Ye Zhu ’’Remote control over both site-selectivity and atroposelectivity of Suzuki–Miyaura coupling through distal ionic interactions’’ Tetrahedron Letters 2023, in press. [open access] (Invited contribution to special issue on Remote Fuctionalization) Ivan Keng Wee On, Wenyang Hong, and Ye Zhu ’’Crossing the ortho-hurdle: Ionic stereocontrol enables atroposelective Suzuki−Miyaura coupling’’ Chem Catalysis 2023, in press. [PDF] DOI:10.1016/j.checat.2023.100523 Mingfeng Li, Xiu Li Chia, Chong Tian and Ye Zhu ’’Mechanically planar chiral rotaxanes through catalytic desymmetrization’’ Chem 2022, 8, 2843–2855. DOI:10.1016/j.chempr.2022.08.009 Mingfeng Li, Xiu Li Chia, and Ye Zhu “Tethered photocatalyst-directed palladium-catalysed C–H allenylation of N-aryl tetrahydroisoquinolines” Chemical Communications 2022, 58, 4719–4722. DOI: 10.1039/D2CC01064J Yazhou Lou, Junqiang Wei, Mingfeng Li, and Ye Zhu “Distal Ionic Substrate–Catalyst Interactions Enable Long-Range Stereocontrol: Access to Remote Quaternary Stereocenters through a Desymmetrizing Suzuki–Miyaura Reaction” Journal of the American Chemical Society 2022, 144, 123–129. DOI: 10.1021/jacs.1c12345 Bin Zheng, Chao Hang, Jason Zhu, Geoffrey E. Purdum, Melda Sezen-Edmonds, Daniel S. Treitler, Miao Yu, Changxia Yuan, Ye Zhu, Adam Freitag, Siwei Guo, Guanghui Zhu, Ben Hritzko, James Paulson, Jonathan G. Shackman, Brian L. He, Weiqing Fu, Hua Chia Tai, Sloan Ayers, Hyunsoo Park, Martin D. Eastgate, Ben Cohen, Amanda Rogers, Qinggang Wang, and Michael A. Schmidt “P(III) vs P(V): A P(V) Reagent for Thiophosphoramidate Linkages and Application to an Asymmetric Synthesis of a Cyclic Dinucleotide STING Agonist” The Journal of Organic Chemistry 2022, 87, 1934–1940. Kyle W. Knouse, Justine N. deGruyter, Michael A. Schmidt, Bin Zheng, Julien C. Vantourout, Cian Kingston, Stephen E. Mercer, Ivar M. Mcdonald, Richard E. Olson, Ye Zhu, Chao Hang, Jason Zhu, Changxia Yuan, Qinggang Wang, Peter Park, Martin D. Eastgate, and Phil S. Baran “Unlocking P(V): Reagents for Chiral Phosphorothioate Synthesis” Science 2018, 361, 1234–1238. Gregory Beutner, Ronald Carrasquillo, Peng Geng, Yi Hsiao, Eric C. Huang, Jacob Janey, Kishta Katipally, Sergei Kolotuchin, Thomas La Porte, Andrew Lee, Paul Lobben, Federico Lora-Gonzalez, Brendan Mack, Boguslaw Mudryk, Yuping Qiu, Xinhua Qian, Antonio Ramirez, Thomas M. Razler, Thorsten Rosner, Zhongping Shi, Eric Simmons , Jason Stevens, Jianji Wang, Carolyn Wei, Steven R. Wisniewski , and Ye Zhu “Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes” Organic Letters 2018, 20, 3736–3740. Nachiket Likhite, Sivaraj Ramasamy, Shankar Tendulkar, Shunmugaraj Sathasivam, Michael Luzung, Ye Zhu, Neil Strotman, Jeffrey Nye, Adrian Ortiz, Susanne Kiau, Martin D. Eastgate, and Rajappa Vaidyanathan “Development of a Safe and Robust Process for the Large-Scale Preparation of a Vinyl Bromide from a Ketone Using a (PhO)3P/Br2-Derived Reagent” Organic Process Research & Development, 2016, 20, 977–981.