Silvi, Mattia - University of Nottingham

个人简介

Dr. Mattia Silvi was born in Rieti (Italy) and obtained his BSc degree in Analytical Chemistry and MSc degree in Organic Chemistry at the University Sapienza (Rome, Italy) working in the laboratory of Prof. Marco Bella. He then carried out his doctoral studies at the Institute of Chemical Research of Catalonia, ICIQ (Tarragona, Spain) under the supervision of Prof. Paolo Melchiorre, working in the fields of organocatalysis and photochemistry (2011-2015). He spent part of his PhD at the University of Michigan (Ann Arbor, MI, United States) in the group of Prof. John P. Wolfe working in the field of palladium and silver catalysed organic reactions (2014). After his PhD he was awarded a Marie Skłodowska-Curie European Individual Fellowship and moved to the University of Bristol (United Kingdom) in the group of Prof. Varinder K. Aggarwal FRS, where he worked in the fields of boron chemistry, photochemistry and prostanoids synthesis (2016-2019). In 2019 he was awarded a Nottingham Research Fellowship to start his independent career at the GSK Carbon Neutral Laboratories, University of Nottingham (United Kingdom). Mattia is the recipient of a 2020 EPSRC New Investigator Award and was selected as outstanding reviewer for 2020 by the RSC for the journal Chemical Science. His research interests lie within the fields of sustainable organic chemistry, radical chemistry, photochemistry and asymmetric catalysis.

研究领域

Solar light is a green and inexhaustible energy source. In our laboratory, we explore the use of visible light for the development of novel methodologies in organic chemistry. Projects ongoing involve the generation of reactive radical species under remarkably mild conditions harnessing the potential of photoredox catalysis. The main target is to develop novel convenient reactivity platforms to transform cheap and available organic feedstocks into valuable molecules.

近期论文

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DAVENPORT, RAFFAEL, SILVI, MATTIA, NOBLE, ADAM, HOSNI, ZIED, FEY, NATALIE and AGGARWAL, VARINDER KUMAR, 2020. Visible Light-Driven Strain-Increase Ring Contraction Allows the Synthesis of Cyclobutyl Boronic Esters. Angewandte Chemie (International ed. in English). SILVI, MATTIA and AGGARWAL, VARINDER K., 2019. Radical Addition to Strained sigma-Bonds Enables the Stereocontrolled Synthesis of Cyclobutyl Boronic Esters JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 141(24), 9511-9515 SILVI, MATTIA, SCHROF, RAFFAEL, NOBLE, ADAM and AGGARWAL, VARINDER K., 2018. Enantiospecific Three-Component Alkylation of Furan and Indole CHEMISTRY-A EUROPEAN JOURNAL. 24(17), 4279-4282 SILVI, MATTIA and MELCHIORRE, PAOLO, 2018. Enhancing the potential of enantioselective organocatalysis with light NATURE. 554(7690), 40-48 VERRIER, CHARLIE, ALANDINI, NURTALYA, PEZZETTA, CRISTOFER, MOLITERNO, MAURO, BUZZETTI, LUCA, HEPBURN, HAMISH B., VEGA-PENALOZA, ALBERTO, SILVI, MATTIA and MELCHIORRE, PAOLO, 2018. Direct Stereoselective Installation of Alkyl Fragments at the beta-Carbon of Enals via Excited Iminium Ion Catalysis ACS CATALYSIS. 8(2), 1062-1066 PELSS, ANDREJS, GANDHAMSETTY, NARASIMHULU, SMITH, JAMES R., MAILHOL, DAMIEN, SILVI, MATTIA, WATSON, ANDREW J. A., PEREZ-POWELL, ISABEL, PREVOST, SEBASTIEN, SCHUTZENMEISTER, NINA, MOORE, PETER R. and AGGARWAL, VARINDER K., 2018. Reoptimization of the Organocatalyzed Double Aldol Domino Process to a Key Enal Intermediate and Its Application to the Total Synthesis of Delta(12)-Prostaglandin J(3) CHEMISTRY-A EUROPEAN JOURNAL. 24(38), 9542-9545 SILVI, MATTIA, VERRIER, CHARLIE, REY, YANNICK P., BUZZETTI, LUCA and MELCHIORRE, PAOLO, 2017. Visible-light excitation of iminium ions enables the enantioselective catalytic beta-alkylation of enals NATURE CHEMISTRY. 9(9), 868-873 SILVI, MATTIA, SANDFORD, CHRISTOPHER and AGGARWAL, VARINDER K., 2017. Merging Photoredox with 1,2-Metallate Rearrangements: The Photochemical Alkylation of Vinyl Boronate Complexes JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 139(16), 5736-5739 FILIPPINI, GIACOMO, SILVI, MATTIA and MELCHIORRE, PAOLO, 2017. Enantioselective Formal alpha-Methylation and alpha-Benzylation of Aldehydes by Means of Photo-organocatalysis ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 56(16), 4447-4451 GARLETS, ZACHARY J., SILVI, MATTIA and WOLFE, JOHN P., 2016. Synthesis of Cyclic Guanidines via Silver-Catalyzed Intramolecular Alkene Hydroamination Reactions of N-Allylguanidines ORGANIC LETTERS. 18(10), 2331-2334 JOHN J. MURPHY, MATTIA SILVI and PAOLO MELCHIORRE, 2016. Enamine-Mediated Catalysis (n - π*). In: EDWIN VEDEJS and SCOTT DENMARK, eds., Lewis Base Catalysis in Organic Synthesis, Vol. 2. Wiley. 857 - 902 SILVI, MATTIA, ARCEO, ELENA, JURBERG, IGOR D., CASSANI, CARLO and MELCHIORRE, PAOLO, 2015. Enantioselective Organocatalytic Alkylation of Aldehydes and Enals Driven by the Direct Photoexcitation of Enamines JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 137(19), 6120-6123 SILVI, MATTIA, CHATTERJEE, INDRANIL, LIU, YIANKAI and MELCHIORRE, PAOLO, 2013. Controlling the Molecular Topology of Vinylogous Iminium Ions by Logical Substrate Design: Highly Regio- and Stereoselective Aminocatalytic 1,6-Addition to Linear 2,4-Dienals ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 52(41), 10780-10783 SILVI, MATTIA, RENZI, POLYSSENA, ROSATO, DEBORAH, MARGARITA, CRISTIANA, VECCHIONI, ALESSIO, BORDACCHINI, IVAN, MORRA, DIEGO, NICOLOSI, ALESSANDRO, CARI, RICCARDO, SCIUBBA, FABIO, SCHIETROMA, DANIELE M. SCARPINO and BELLA, MARCO, 2013. Enantioselective Aza-Michael Addition of Imides by Using an Integrated Strategy Involving the Synthesis of a Family of Multifunctional Catalysts, Usage of Multiple Catalysis, and Rational Design of Experiment CHEMISTRY-A EUROPEAN JOURNAL. 19(30), 9973-9978 SILVI, MATTIA, CASSANI, CARLO, MORAN, ANTONIO and MELCHIORRE, PAOLO, 2012. Secondary Amine-Catalyzed Asymmetric gamma-Alkylation of alpha-Branched Enals via Dienamine Activation HELVETICA CHIMICA ACTA. 95(10), 1985-2006