个人简介
牟海津，博士，教授，博士研究生导师，英国 Reading University 博士后，教育部新世纪优秀人才，山东省泰山学者特聘专家，国际期刊《 Marine Life Science and Technology 》领域主编，青岛市拔尖人才，青岛市政协委员，青岛市首批“未来之星”高端人才，威海市产业领军人才，中国海洋大学海洋微生物工程团队负责人。
海洋微生物工程研究室的成立可以追溯到 1953 年，是国内最早开展海洋微生物应用开发的研究团队之一。研究室以开发海洋微生物资源为主要目标，对海洋微生物的代谢产物进行基础生物学研究和功能评价，特别是发掘具有重要价值的海洋环境微生物及其基因资源，开展分子模拟与过程控制等基础研究，以基因工程、酶工程和代谢工程为手段，构建海洋微生物的工程化开发体系，实现海洋微生物应用开发与产业转化。具体工作包括：具有工业潜力的海洋微生物新菌种的高通量筛选、育种及代谢调控；海洋微生物酶的基因挖掘、理性改造与产业化应用；海洋功能糖的酶促制备、构效评价、肠道互作与功能研究；海洋特殊环境微生物的生理与代谢组学研究；海洋生物资源的高值化发酵工程技术研究。
所获奖项（第一完成人）
山东省科技进步奖二等奖 “海洋高值化工程酶的开发及功能食品的生物制造”
山东省科技进步二等奖 “海洋功能糖精准制备关键技术及其在健康产业中的应用”
农业农村部2019—2021年度全国农牧渔业丰收奖二等奖 “海洋生物工程技术在生物替抗产业中的应用”
国家海洋局海洋科学技术奖 “海藻多糖资源的生物转化工程技术研究”
中国发明协会发明创业奖创新奖二等奖 “海洋生物工程技术在新型功能糖制备中的应用”
中国科技产业化促进会科学技术奖二等奖
中国水产科学研究院科学技术二等奖
山东省优秀博士论文
第五届中国-阿拉伯技术转移与创新合作十项主推重要科技成果 “海洋功能糖开发技术与产业化应用”
“海洋高值化工程酶的开发及功能食品的生物制造”等7项成果经评价达到国际领先水平
科研成果
所从事的研究方向为海洋微生物工程。发表论文238篇，上榜2024全球2%顶尖科学家；获授权国家发明专利75项、国际发明专利4项；制定地方或团体标准8件；主编我国第一部《海洋微生物工程》。
编写教材专著
1. 《海洋微生物工程》，主编，ISBN 978-7-5670-1112-0。
2. 全国农业推广专业学位研究生教育指导委员会推荐教材《食品原料生产安全控制技术》，副主编。
3. Editorial: Marine microorganisms and their enzymes with biotechnological application, Frontiers in Microbiology, 2022，主编。
研究领域
1、海洋微生物功能酶与功能基因的发现与挖掘
2、功能低聚糖制备的生物技术研究及健康产品开发
3、海洋资源高值化生物转化技术研究与产业化建设
4、海洋生物替抗工程技术创新与示范
近期论文
查看导师新发文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
1. Low molecular weight galactomannan alleviates diarrhea induced by senna leaf in mice via intestinal barrier improvement and gut microbiota modulation. Food & Function. 2025. DOI: 10.1039/D4FO04375H
2. Heterologous expression of a recombinant ACE inhibitory peptide LYPVK and its potential antihypertensive action. International Journal of Biological Macromolecules, 2025, 300: 140274.
3. Current status and potential of bacteriocin-producing lactic acid bacteria applied in the food industry. Current Research in Food Science, 2025. DOI: 10.1016/j.crfs.2025.100997
4. Impact of 2’-fucosyllactose on adult gut microbiota composition and metabolome based on colonic fermentation and prebiotic quantitative evaluation. Journal of Food Science, 2025. DOI: 10.1111/1750-3841.70084
5. Structural characterization of bacterial fucose-containing tetrasaccharide and its potential enhancement on intestinal barrier function. Food Bioscience, 2025. DOI: 10.1016/j.fbio.2025.106256
6. Exploration of ACE inhibitory peptides from sea cucumber viscera with DPP-IV inhibitory activity: Virtual screening, characterization, and potential mechanism investigation. International Journal of Biological Macromolecules, 2025, 311: 143843.
7. Mining for novel umami peptides from sea cucumber viscera hydrolysate with ACE inhibitory activity. Journal of Agricultural and Food Chemistry, 2025. DOI: 10.1021/acs.jafc.5c04439
8. Improving activity of ACE inhibitory peptide by sequence-based rational design: Properties, function on endothelial cells, and potential antihypertensive mechanism. Food Frontiers. 2025. DOI: 10.1002/fft2.70076
9. A novel exploration of the extraction of sea cucumber glycoproteins and their potential mechanism in prediabetes intervention. Food Research International, 2025, 218: 116881.
10. Prebiotic potential of exopolysaccharide-derived oligosaccharides prepared using sandwich-integration bioprocess of acidolysis-electrodialysis and microbial fermentation. Food Chemistry: X, 2025, 29: 102718.
11. New Strategy for the Degradation of High-Concentration Sodium Alginate with Recombinant Enzyme 102C300C-Vgb and the Beneficial Effects of Its Degradation Products on the Gut Health of Stichopus japonicus. Marine Drugs, 2025. DOI: 10.3390/md23090339
12. Rational module substitution strategy to enhance ACE-inhibitory peptide activity. Food Chemistry, 2025, 494: 146191.
13. Detoxification and nutritional improvement of defatted cottonseed meal through sequential co-fermentation and the production of a low toxic cottonseed peptides. Industrial Crops & Products, 2025, 236: 121913.
14. Selecting preculture strategy for improving biomass and astaxanthin productivity of Chromochloris zofingiensis. Applied Microbiology and Biotechnology, 2024, 108:1–17.
15. Microalgal protein for sustainable and nutritious foods: A joint analysis of environmental impacts, health benefits and consumer’s acceptance. Trends in Food Science & Technology, 2024, 143: 104278.
16. Preparation, structural characterization and rheological properties of a novel fucose-containing exopolysaccharide from Clavibacter michiganensis. Food Hydrocolloids. 2024, 109850.
17. Upcycling food waste into biorefinery production by microalgae. Chemical Engineering Journal. 2024, 149532.
18. Development Strategies and Application of Antimicrobial Peptides as Future Alternatives to In-feed Antibiotics. Science of the Total Environment, 2024, 927:172150.
19. Evaluation of potential prebiotic activity of a novel fucose-containing trisaccharide prepared from bacterial exopolysaccharides. Food Bioscience, 2024, 60: 104380.
20. Identification, expression, and characterization of a marine-derived chitinase Ce0303 from Chitiniphilus eburneus with exo- and endo-hydrolytic properties. International Journal of Biological Macromolecules. 2024. DOI: 10.1016/j.ijbiomac.2024.133980
21. A novel gossypol-degradation approach by Meyerozyma guilliermondii WST-M1 and its application in the development of cottonseed meal as feed resource. Industrial Crops & Products, 2024, 220:119299.
22. Current challenges and development strategies of bacteriocins produced by lactic acid bacteria applied in the food industry. Comprehensive Reviews in Food Science and Food Safety. 2024. DOI: 10.1111/1541-4337.70038
23. Protein and lysine improvement harnessed by a signal chain of red light-emitting diode light in Chlorella pyrenoidosa. Bioresource Technology, 2024, 414: 131620.
24. Marine-derived fucose-containing carbohydrates: Review on sources, structure, and beneficial effects of gastrointestinal health. Foods, 2024, 13, 3460.
25. High-efficiency expression of alginate lyase in Pichia pastoris facilitated by Vitreoscilla hemoglobin. International Journal of Biological Macromolecules, 2024. DOI: 10.1016/j.ijbiomac.2024.137027
26. Realization process of microalgal biorefinery: the optional approach toward carbon net-zero emission. Science of the Total Environment, 2023. DOI: 10.1016/j.scitotenv.2023.165546
27. Antibacterial activity of bifunctional bacterial cellulose composite grafted with glucose oxidase and l-arginine. Cellulose, 2023. DOI: 10.1007/s10570-023-05406-2
28. High-efficiency heterologous expression of nattokinase based on a combinatorial strategy. Process Biochemistry, 2023. DOI: 10.1016/j.procbio.2023.08.008
29. Stimulating carbon and nitrogen metabolism of Chlorella pyrenoidosa to treat aquaculture wastewater and produce high-quality protein in plate photobioreactors. Science of the Total Environment. 2023. DOI: 10.1016/j.scitotenv.2023.163061
30. Technological readiness of commercial microalgae species for foods. Critical Reviews in Food Science and Nutrition, 2023. DOI: 10.1080/10408398.2023.2194423
31. Structural characterization of a novel fucosylated trisaccharide prepared from bacterial exopolysaccharides and evaluation of its prebiotic activity. Food Chemistry. 2023, 420: 136122.
32. Butyrogenic effect of galactosyl and mannosyl carbohydrates and their regulation on piglet intestinal microbiota. Applied Microbiology and Biotechnology, 2023. DOI: 10.1007/s00253-023-12436-0
33. High-efficiency fermentation of nattokinase by recombinant PSP2 using oyster peptide as a substrate. Foods, 2023, 12, 1252.
34. A novel gluco-fucobiose with potential prebiotic activity prepared from the exopolysaccharides of Clavibacter michiganensis M1. Food Chemistry, 2022, 377: 132001.
35. Fucose-containing bacterial exopolysaccharides: sources, biological activities, and food applications. Food Chemistry: X, 2022, 13: 100233.
36. Marine-derived uronic acid-containing polysaccharides: Structures, sources, production, and nutritional functions. Trends in Food Science & Technology, 2022, 122: 1-12.
37. Fucoxanthin from marine microalgae: A promising bioactive compound for industrial production and food application. Critical Reviews in Food Science and Nutrition, 2022. DOI: 10.1080/10408398.2022.2054932
38. Response mechanism of Vibrio parahaemolyticus at high pressure revealed by transcriptomic analysis. Applied Microbiology and Biotechnology, 2022. DOI: 10.1007/s00253-022-12082-y
39. Complete-genome sequence and in vitro probiotic characteristics analysis of Bifidobacterium pseudolongum YY-26, a potential probiotic. Journal of Applied Microbiology, 2022. DOI: 10.1111/jam.15730
40. Genome analysis and 2'-fucosyllactose utilization characteristics of a new Akkermansia muciniphila strain isolated from mice feces. Molecular Genetics and Genomics, 2022. DOI: 10.1007/s00438-022-01937-8
41. Effects of intestinal microflora on physiological metabolism and pathogenicity of Vibrio. Frontiers in Microbiology, 2022. DOI: 10.3389/fmicb.2022.947767
42. Amelioration of hydrolyzed guar gum on high-fat diet-induced obesity: Integrated hepatic transcriptome and metabolome. Carbohydrate Polymers. 2022. DOI: 10.1016/j.carbpol.2022.120051
43. Characterization of a recombinant antimicrobial peptide BMGlv2 heterologously expressed in Trichoderma reesei. International Journal of Molecular Sciences, 2022, 23, 10291.
44. Structural characterization of fucose-containing disaccharides prepared from exopolysaccharides of Enterobacter sakazakii. Carbohydrate Polymers. 2021, 252: 117139.
45. Improving the kinetic stability of a hyperthermostable β-mannanase by a rationally combined strategy. International Journal of Biological Macromolecules, 2021, 167:405-414.
46. A multi-functional genetic manipulation system and its use in high-level expression of a β-mannanase mutant with high specific activity in Pichia pastoris. Microbial Biotechnology. 2021. DOI: 10.1111/1751-7915.13812
47. Surface charged amino acid-based strategy for rational engineering of kinetic stability and specific activity of enzymes: linking experiments with computational modeling. International Journal of Biological Macromolecules, 2021. DOI: 10.1016/j.ijbiomac.2021.03.198
48. Improvement of the catalytic ability of a thermostable and acidophilic β‐mannanase using a consensus sequence design strategy. Frontiers in Microbiology, 2021. DOI: 10.3389/fmicb.2021.722347
49. Potassium alginate oligosaccharides alter gut microbiota and have potential to prevent the development of hypertension and heart failure in spontaneously hypertensive rats. International Journal of Molecular Sciences, 2021, 22, 9823.
50. Genome sequence analysis of Cronobacter phage PF-CE2 and proposal of a new species in the genus Pseudotevenvirus. Archives of Virology. 2021. DOI: 10.1007/s00705-021-05255-z
51. Regulation of virulence factors expression during the intestinal colonization of Vibrio parahaemolyticus. Foodborne Pathogens and Disease, 2021. DOI: 10.1089.fpd.2021.0057
52. High-level expression of a thermophilic and acidophilic β-mannanase from Aspergillus kawachii IFO 4308 with significant potential in mannooligosaccharide preparation. Bioresource Technology, 2020, 295: 122257.
53. Partially degraded chitosan-based flocculation to achieve effective deodorization of oyster (Crassostrea gigas) hydrolysates. Carbohydrate Polymers, 2020. DOI: 10.1016/j.carbpol.2020.115948
54. Bacteriostatic effect of lipopeptides from Bacillus subtilis N-2 on Pseudomonas putida using soybean meal by solid-state fermentation. Marine Life Science & Technology, 2020. DOI: 10.1007/s42995-020-00028-0
55. Enzymatic preparation of low-molecular-weight polysaccharide rich in uronic acid from the seaweed Laminaria japonica and evaluation of its hypolipidemic effect in mice. Food & Function, 2020, 11, 2395–2405.
56. Properties of hydrolyzed guar gum fermented in vitro with pig fecal inocula and its favorable impacts on microbiota. Carbohydrate Polymers, 2020, 237: 116116.
57. High-efficiency expression of a superior β-mannanase engineered by cooperative substitution method in Pichia pastoris and its application in preparation of prebiotic mannooligosaccharides. Bioresource Technology, 2020. DOI: 10.1016/j.biortech.2020.123482
58. Dietary galactosyl and mannosyl carbohydrates: In-vitro assessment of prebiotic effects. Food Chemistry, 2020. DOI: 10.1016/j.foodchem.2020.127179
59. Expression and characterization of an alginate lyase and its thermostable mutant in Pichia pastoris. Marine Drugs, 2020, 18(6), 305.
60. A thermostable glucose oxidase from Aspergillus heteromophus CBS 117.55 with broad pH stability and digestive enzyme resistance. Protein Expression and Purification, 2020, 176: 105717.
61. A New Cold-active Glucose Oxidase from Penicillium: High-Level Expression and Application in Fish Preservation. Frontiers in Microbiology, 2020. DOI: 10.3389/fmicb.2020.606007
学术兼职
⚫ 中国民间中医医药研究开发协会海洋医学分会 会长
⚫ 中国农业机械学会农副产品加工分会 副主任委员
⚫ 全国饲料产业技术创新战略联盟 副理事长兼专家委员会副主任
⚫ 全国无抗产业科技创新联盟 副理事长
⚫ 山东省农业机械学会水产专委会 主任委员
⚫ 国际权威期刊《 Marine Life Science and Technology 》 领域主编
⚫ 《 Frontiers in Microbiology 》 副主编
⚫ 国际食物营养与安全协会 International association of dietetic nutrition and safety 理事
⚫ 中国海洋学会海洋生物工程专业委员会 常务委员
⚫ 中国食品药品企业质量安全促进会功能食品分会专家委员
⚫ 教育部环境食品学重点实验室学术委员会 委员
⚫ 山东省食品科学技术学会 常务理事
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