王平原 - 中国海洋大学 - 海洋生物多样性与进化研究所

个人简介

王平原教授博士生导师中国海洋大学“青年英才工程”第一层次特聘教授 Dr. Pingyuan Wang Education: B.Sc.Chemistry, Central China Normal University (2006-2010) Ph. D .Medicinal Chemistry and Pesticide science, Central China Normal University and Shanghai Institute of Materia Medica, Chinese Academy of Sciences (2010-2016) Work Experience： Postdoc Department of Pharmacology & Toxicology, University of Texas Medical Branch (2016.06-2021.06) Professor Institute of Evolution & Marine Biodiversity, Ocean University of China (2020.9- ) Research Interests: Design, synthesis and biological evaluations of small molecules as chemical probes for probing function or pharmacological tools for cancer, inflammations, CNS disorders and other human diseases. 发表 J. Med. Chem. 、 Euro. J. Med. Chem. 、 Org. Lett. 等 SCI 论文 20 余篇，其中第一作者 ( 含共一 )SCI 文章 12 篇；申请专利 8 项，授权 2 项；获得美国德克萨斯大学颁发的 Herin 转化研究奖 “Herin Translational Research Award” ；受邀多次为 Cancers 和 Cells 等杂志审稿人。

研究领域

基于海洋天然产物的药物先导物发现以神经系统疾病、肿瘤和炎症等人类重大疾病为导向，运用基于天然产物和老药新用的新型小分子药物发现策略，围绕钠通道、 GPCR 和 cAMP 信号转导通路为靶标，进行分子靶向的药物先导化合物发现及其作用机制研究。 Design, synthesis and biological evaluations of small molecules as chemical probes for probing function or pharmacological tools for cancer, inflammations, CNS disorders and other human diseases.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. P. Wang , D. van der Hoeven, N. Ye, H. Chen, Z. Liu, X. Ma, D. Montufar-Solis, K. M. Rehl, K. Cho, S. Thapa, W. Chen, R. van der Hoeven, J. A. Frost, J. F. Hancock, J. Zhou. Scaffold repurposing of fendiline: identification of potent KRAS plasma membrane localization inhibitors. Eur . J . Med. Chem . 2021, 217, 113381. 2. P. Wang , D. E. Felsing, H. Chen, S. J. Stutz, R. E. Murphy, K. A. Cunningham, J. A. Allen, J. Zhou. Discovery of Potent and Brain Penetrant GPR52 Agonists that Suppress Psychostimulant Behavior. J. Med. Chem. 2020, 63 , 13951-13972. 3. P. Wang , P.A. Wadsworth, N. M. Dvorak, A. K. Singh, H. Chen, Z. Liu, R. Zhou, L. M. F. Holthauzen, J. Zhou, F. Laezza. Design, Synthesis, and Pharmacological Evaluation of Analogs Derived from the PLEV Tetrapeptide as Protein-Protein Interaction Modulators of Voltage-Gated Sodium Channel 1.6. J. Med. Chem. 2020, 63 , 11522-11547. 4. P. Wang , U. Luchowska-Stańska, B. V. Basten, H. Chen, Z. Liu, J. Wiejak, P. Whelan, D. Morgan, E. Lochhead, G. Barker, H. R., S. J. Yarwood, J. Zhou. Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators. J. Med. Chem. 2020, 63 , 5159-5184. 5. P. Wang , D. E. Felsing, H. Chen, S. R. Raval, J. A. Allen, J. Zhou. Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists. ACS Med. Chem. Lett. 2019, 10, 792-799. 6. Y. Wang,# P. Wang ,# Y. Wang, G. Yang, A. Zhang, Z. Miao. An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy. J. Med. Chem. 2016, 59 , 9575-9598. 7. P. Wang , S. Song, Z. Miao, G. Yang, A. Zhang. InBr3-Mediated One-Pot Synthesis of 2-(Polyhydroxylatedalkyl)-N-aryl-/-alkylpyrroles from 1,2-Cyclopropa-3-pyranone and Amines. Org. Lett. 2013, 15 , 3852-3855.