Woodhall, Gavin - Aston University - School of Life & Health Sciences, Pharmacy

个人简介

1998–2002 Post-doctoral researcher, University of Bristol. 1995–1998 Postdoctoral fellow University of Montreal, Canada. 1994–1995 Postdoctoral Fellow University of Southampton. 1991–1994 PhD University of Southampton

研究领域

Electrophysiological studies on neurones of the entorhinal cortex (EC). The role of presynaptic metabotropic glutamate and NMDA receptors in epilepsy in the EC The role of cannabinoids in the EC The role of primary motor cortex in epilepsy and Parkinson’s disease (in collaboration with Dr. Ian Stanford and Dr. Stephen Hall). The EC is part of the temporal lobe, a brain region which is especially prone to epilepsy. My research focuses on how epilepsy leads to changes the presynaptic control of neurotransmitter release onto neurones in the deep and superficial layers of the EC, and on the relationship between control of action potential evoked and action potential independent release of glutamate and GABA. I am also interested in the role of presynaptic CB1 cannabinoid receptors in control of GABA release in the normal and chronically epileptic EC. I am currently setting up a human tissue laboratory to investigate these questions in human brain slices. I am also interested in primary motor cortex (M1), and am currently investigating neuronal network oscillations in this area, with a view to understanding how activity in M1 is altered through synaptic plasticity in epilepsy and Parkinson’s disease. These experiments are complemented by investigations in man via MEG studies (Steve Hall).

近期论文

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Lacey MG, Gooding-Williams G, Prokic EJ, Yamawaki N, Hall SD, Stanford IM, and Woodhall GL (2014). Spike firing and IPSPs in layer V pyramidal neurons during beta oscillations in rat primary motor cortex (M1) in vitro. PLOS ONE (in press) Greenhill SD, Chamberlain SEL, Lench A, Massey PV, Yuill, KY, Woodhall GL, Jones RSG. (2014) Background synaptic activity in rat entorhinal cortex shows a progressively greater dominance of inhibition over excitation from deep to superficial layers. PLoS ONE (in press) Hall S.D., Yamawaki N., Clauss R., Fischer A., Woodhall G.L., Stanford I.M. (2009) Desynchronization of pathological low frequency brain activity by the hypnotic drug zolpidem. Brain (submitted)* Sims R.E.., Woodhall G.L., Wilson C.L., Stanford I.M. (2008) Functional characterization of GABAergic pallido-pallidal and striato-pallidal synapses in the rat globus pallidus in vitro. Eur. J. Neurosci. (in press).* Morgan N., Stanford I.M., Woodhall G.L. (2008)Modulation of network oscillatory activity and GABAergic synaptic transmission by CB1 cannabinoid receptors in the rat medial entorhinal cortex.Neural Plasticity (in press) Loucif, A.J.C., Woodhall G.L, Sehirli U.S., Stanford I.M. (2008) Depolarisation and suppression of burst firing in the mouse subthalamic nucleus by dopamine D1-like receptor activation of a cyclic nucleotide gated non-specific cation conductance. Neuropharm. 55, 94-105. Yang J, Woodhall GL, Jones RS. (2008) Evidence for mobile presynaptic NMDA receptors at cortical synapses.J Physiol. (586(Pt 20):4905-24) Yamawaki N, Hall, SD, Stanford IM & Woodhall GL (2008) Pharmacologically induced and stimulus evoked neuronal oscillatory activity in the primary motor cortex in vitro.Neuroscience 151(2):386-95 Woodhall GL, Ayman G, Jones RSG. (2007)Differential control of two forms of glutamate release by group III metabotropic glutamate receptors at rat entorhinal synapses Neuroscience 148 (1) 7-21 Thompson SE, Ayman G, Woodhall GL, Jones RSG (2006)Depression of glutamate and GABA release by Presynaptic GABA(B) receptors in the entorhinal cortex in normal and chronically epileptic rats. Neurosignals 15 (4) 202-215 Yang J, Woodhall GL, Jones RS. (2006) Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats. Journal of Neuroscience. 26(2):406-10. Woodhall GL, Bailey SJ, Thompson SE, Evans DI, Jones RS. (2005)Fundamental differences in spontaneous synaptic inhibition between deep and superficial layers of the rat entorhinal cortex. Hippocampus. 15(2):232-45. Jones RS, Woodhall GL. (2005)Background synaptic activity in rat entorhinal cortical neurones: differential control of transmitter release by presynaptic receptors. Journal of Physiology. 562(Pt 1):107-20. Cunningham, MO, Woodhall, GL, Thompson, SE, Dooley, DJ and Jones, RSG (2004)Dual effects of gabapentin and pregabalin on glutamate release at rat entorhinal synapses in vitro European Journal of Neuroscience 20 1566-1576.