Rafiq, Qasim - Aston University - School of Life & Health Sciences, Biology/Biosciences

个人简介

2013 – PhD in Regenerative Medicine Bioprocessing, Loughborough University, UK (Funded by EPSRC and Lonza Cologne AG) 2008 – MEng (Hons) Biochemical Engineering, University College London (UCL), UK 2014 – PRINCE2? Practitioner, accredited by BCS 2015 – Business Analysis Practitioner, accredited by BCS 2015 – Green Belt in Lean Six Sigma, accredited by The Knowledge Academy 2015 – Change Management Practitioner, accredited by APMG Feb 2015 - present: Lecturer in Bioprocess Engineering, School of Life and Health Sciences, Aston University, UK Feb 2013 – Feb 2015: EPSRC E-TERM Landscape Research Fellow, Loughborough University, UK Jun 2005 – Sep 2005:Assistant Reagents Technician, Genzyme Ltd, Kent, UK

研究领域

I have been working in the field of Bioprocess Engineering for over 8 years, and recently my research has focused on the bioprocessing of stem cells for their use as cell therapy and regenerative medicine products. This has included both the upstream and downstream process development, with a particular focus on the use of stirred-tank bioreactors for the expansion and harvest of stem cells. Recent focus has shifted to understanding the underlying biological environment, how the cell interacts with and is affected by the culture conditions with the aim of utilising this information to make informed advancements for bioprocess development. The research area and skills are transferable to many other areas in biotechnology including microbial fermentation, monoclonal antibody production, industrial biotechnology and synthetic biology. Bioprocess development for advanced therapeutics (cell, gene and tissue-based products) including the manufacture, translation and commercialisation of these products for clinical use.

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Rafiq, Q.A., Toward a scalable and consistent manufacturing process for the production of human mesenchymal stem cells. Cell and Gene Therapy Bioinsights. In Press. Heathman, T.R.J., Stolzing A., Fabian C., Rafiq Q.A., Coopman K., Nienow A.W., Kara B., Hewitt C.J. 2015. Scalability and process transfer of mesenchymal stromal cell production from monolayer to microcarrier culture using human platelet lysate, Cytotherapy, In Press. Rafiq, Q.A., Coopman K., Nienow A.W., Hewitt, C.J. 2015. Systematic microcarrier screening and agitated culture conditions improves human mesenchymal stem cell yield in bioreactors, Biotechnology Journal, DOI: 10.1002/biot.201400862. Rafiq, Q.A., Wilson S.L., Ortega I., Patel A.K., Jenkins S.I., Barnes A., Derfogail D., Adams C., Smith D., 2015. The early career researcher’s toolkit: translating tissue engineering, regenerative medicine and cell therapy products, Regenerative Medicine, 10, 989-1003. Heathman, T.R.J., Stolzing A., Fabian C., Rafiq Q.A., Coopman K., Nienow A.W., Kara B., Hewitt C.J. 2015. Serum-free process development: improving the yield and consistency of human mesenchymal stromal cell production. Cytotherapy, 17, 1524-1535. Nienow A.W., Hewitt C.J., Heathman T.R.J, Glyn V.A.M., Fonte G.N., Hanga M.P., Coopman K., Rafiq Q.A. 2015. Agitation conditions for the culture and detachment of hMSCs from microcarriers in multiple bioreactor platforms, Biochemical Engineering Journal, doi:10.1016/j.bej.2015.08.003 Heathman, T.R.J., Rafiq, Q.A., Chan A, Coopman K, Nienow A.W., Kara B., Hewitt C.J. 2015. Characterization of human mesenchymal stem cells from multiple donors and the implications for large scale bioprocess development. Biochemical Engineering Journal, doi:10.1016/j.bej.2015.06.018. Rafiq, Q.A., Hewitt C.J. 2015. Cell therapies: why scale matters. Pharmaceutical Bioprocessing. 3, 97-99. Heathman, T.R.J., Glyn, A., Picken A., Rafiq, Q.A., Coopman K, Nienow A.W., Kara B., Hewitt C.J. 2015. Expansion, Harvest and Cryopreservation of Human Mesenchymal Stem Cells in a Serum-free Microcarrier Process. Biotechnology and Bioengineering, 112, 1696 – 1707. Nienow, A. W.*, Rafiq, Q. A.*, Coopman, K. & Hewitt, C. J. 2014. A potentially scalable method for the harvesting of hMSCs from microcarriers. Biochemical Engineering Journal, 85, 79-88. (* These authors contributed equally to this work) Rafiq, Q. A., Brosnan, K. M., Coopman, K., Nienow, A. W. & Hewitt, C. J. 2013. Culture of human mesenchymal stem cells on microcarriers in a 5 l stirred-tank bioreactor. Biotechnology Letters, 35, 1233-1245. Rafiq, Q. A., Coopman, K., Nienow, A. W. & Hewitt, C. J. 2013. A quantitative approach for understanding small-scale human mesenchymal stem cell culture - implications for large-scale bioprocess development. Biotechnology Journal, 8, 459-71. Rafiq, Q. A., Coopman, K. & Hewitt, C. J. 2013. Scale-up of human mesenchymal stem cell culture: current technologies and future challenges. Current Opinion in Chemical Engineering, 2, 8-16.