Griffiths, Helen R - Aston University - School of Life & Health Sciences, Biology/Biosciences

个人简介

2015- date Pro-Vice-Chancellor International Relations, Aston University 2009-2014 Executive Dean, LHS 2005–date Professor in Biomedical Sciences, Aston University 1998-2005 Reader in Molecular Biosciences, Aston University 1991-98 Lecturer in Pathology (0.5 FTE), University of Leicester 1989-91 Lecturer in Clinical Chemistry, University of Birmingham 1986-89 PhD, University of Birmingham 1985-86 Research Associate, Dept Immunology, University of Birmingham 1981-85 BSc. Hons, Biochemistry (Class I), University of Bath

研究领域

Nutrient-gene interaction - effects on cellular and plasma omics Interplay between lipids/sphingolipids and reactive oxygen species Immune cell dysfunction during inflammation and ageing Monocyte-endothelial cell dysfunction during inflammation Intracellular redox regulation of cell survival and adaptation Reversible protein oxidation during signalling, and the effects of irreversible modification on function

近期论文

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For a list of full publications with abstracts please go to the database PubMed and enter the search term – Griffiths HR. Perrie, Y, Crofts, F, Devitt, A, Griffiths, HR, Kastner, E & Nadella, V 2016, 'Designing liposomal adjuvants for the next generation of vaccines' Advanced Drug Delivery Reviews, vol. 99, no. Part A, pp. 85-96,10.1016/j.addr.2015.11.005 Ikwuobe, J, Bellary, S & Griffiths, HR 2016, 'Innovative biomarkers for predicting type 2 diabetes mellitus: relevance to dietary management of frailty in older adults' Biogerontology, vol. First online,10.1007/s10522-016-9634-z Pararasa, C, Ikwuobe, J, Shigdar, S, Boukouvalas, A, Nabney, IT, Brown, JE, Devitt, A, Bailey, CJ, Bennett, SJ & Griffiths, HR 2016, 'Age-associated changes in long-chain fatty acid profile during healthy aging promote pro-inflammatory monocyte polarization via PPAR?' Aging Cell, vol. 15, no. 1, pp. 128-139,10.1111/acel.12416 Pararasa, C, Ikwuobe, J, Shigdar, S, Boukouvalas, A, Nabney, IT, Brown, JE, Devitt, A, Bailey, CJ, Bennett, SJ & Griffiths, HR 2016, 'Age-associated changes in long-chain fatty acid profile during healthy aging promote pro-inflammatory monocyte polarization via PPAR?' Aging Cell, vol. 15, no. 1, pp. 128-139,10.1111/acel.12416 Dias, IHK, Brown, CLR, Polidori-Nelles, MC, Lip, GYH & Griffiths, HR 2015, 'LDL-Lipids from patients with hypercholesterolaemia and Alzheimer' s disease are inflammatory to microvascular endothelial cells: mitigation by statin intervention' Clinical Science, vol. 129, no. 12, pp. 1195-1206,10.1042/CS20150351 Bennett, SJ, Augustyniak, EM, Dunston, CR, Brown, RA, Shantsila, E, Lip, GYH, Torr?o, RDC, Pararasa, C, Hussein, AR, Ladouce, R, Friguet, B & Griffiths, HR 2015, 'CD4+T cell surface alpha enolase is lower in older adults' Mechanisms of Ageing and Development, vol. 152, pp. 56–62,10.1016/j.mad.2015.09.005 Bürkle, A, Moreno-Villanueva, M, Bernhard, J, Blasco, M, Zondag, G, Hoeijmakers, JHJ, Toussaint, O, Grubeck-Loebenstein, B, Mocchegiani, E, Collino, S, Gonos, ES, Sikora, E, Gradinaru, D, Dollé, M, Salmon, M, Kristensen, P, Griffiths, HR, Libert, C, Grune, T, Breusing, N, Simm, A, Franceschi, C, Capri, M, Talbot, D, Caiafa, P, Friguet, B, Slagboom, PE, Hervonen, A, Hurme, M & Aspinall, R 2015, 'MARK-AGE biomarkers of ageing' Mechanisms of Ageing and Development, vol. 151, pp. 2-12,10.1016/j.mad.2015.03.006 Zong, G, Scott, A, Griffiths, H, Zock, P, Dietrich, T & Newson, R 2015, 'Serum a-tocopherol has a nonlinear inverse association with periodontitis among US adults' Free Radical Biology and Medicine, vol. 86, no. Suppl.1, PP67, pp. S41-S42,10.1016/j.freeradbiomed.2015.07.142 Dias, IHK, Ademowo, OS, Newey, E & Griffiths, HR 2015, 'The Nrf2-ARE activation protect neurones against oxidative stress' Free Radical Biology and Medicine, vol. 86, no. Suppl.1, PP34, pp. S30-S31,10.1016/j.freeradbiomed.2015.07.109 Meredith, S, Spickett, C, Parekh, G, Schouten, J, Griffiths, H & Davis, P 2015, 'Investigating the ability of antibodies to recognize specific oxidized protein epitopes' Free Radical Biology and Medicine, vol. 86, no. Suppl.1, PP36, pp. S31,10.1016/j.freebiomed.2015.07.0111 McBean, GJ, Aslan, M, Griffiths, HR & Torr?o, RC 2015, 'Thiol redox homeostasis in neurodegenerative disease' Redox biology, vol. 5, pp. 186-194,10.1016/j.redox.2015.04.004 Zong , G, Scott, AE, Griffiths, HR, Zock , PL, Dietrich, T & Newson, RS 2015, 'Serum a-tocopherol has a nonlinear inverse association with periodontitis among US adults' Journal of Nutrition, vol. 145, no. 5, pp. 893-899,10.3945/jn.114.203703 Augustyniak, E, Adam, A, Wojdyla, K, Rogowska-Wrzesinska, A, Willetts, R, Korkmaz, A, Atalay, M, Weber, D, Grune, T, Borsa, C, Gradinaru, D, Chand Bollineni, R, Fedorova, M & Griffiths, H 2015, 'Validation of protein carbonyl measurement: a multi-centre study' Redox biology, vol. 4, pp. 149–157,10.1016/j.redox.2014.12.014 Perrie, Y, Griffiths, HR & Jones, D 2015, 'Enhancing vaccine design strategies: applications for protein science, proteomics and adjuvants' Journal of Pharmacy and Pharmacology, vol. 67, no. 3, pp. 287-289,10.1111/jphp.12414 Ruskovska, T, Bennett, SJ, Brown, CR, Dimitrov, S, Kamcev, N & Griffiths, HR 2015, 'Ankyrin is the major oxidised protein in erythrocyte membranes from end-stage renal disease patients on chronic haemodialysis and oxidation is decreased by dialysis and vitamin C supplementation' Free Radical Research, vol. 49, no. 2, pp. 175-185,10.3109/10715762.2014.991725 Pararasa, C, Bailey, CJ & Griffiths, HR 2015, 'Ageing, adipose tissue, fatty acids and inflammation' Biogerontology, vol. 16, no. 2, pp. 235-248,10.1007/s10522-014-9536-x Marshall, LJ, Oguejiofor, W, Willetts, RS, Griffiths, HR & Devitt, A 2015, 'Developing accurate models of the human airways' Journal of Pharmacy and Pharmacology, vol. 67, no. 3, pp. 464-472,10.1111/jphp.12340 Taylor, S, Lam, M, Pararasa, C, Brown, JEP, Carmichael, AR & Griffiths, HR 2015, 'Evaluating the evidence for targeting FOXO3a in breast cancer: a systematic review' Cancer Cell International, vol. 15, no. 1,10.1186/s12935-015-0156-6 Dunston, CR, Herbert, R & Griffiths, HR 2015, 'Improving T cell-induced response to subunit vaccines: opportunities for a proteomic systems approach' Journal of Pharmacy and Pharmacology, vol. 67, no. 3, pp. 290-299,10.1111/jphp.12383