Han, Renzhi - The Ohio State University Wexner Medical Center

个人简介

B.Sc. (1998) - Peking University Ph.D. (2003) - The University of Western Australia Postdoc (2003-2007) - Howard Hughes Medical Institute

研究领域

The research in the Han Lab is directed to understand the molecular mechanisms of genetic diseases affecting the neuromuscular system, and to develop novel therapeutic strategies to combat these devastating diseases.

近期论文

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Xu L, Zhang C, Li H, Wang P, Gao Y, Mokadam NA, Ma J, Arnold WD, Han R. (2021) Efficient precise in vivo base editing in adult dystrophic mice Nature Communications 12(1): 3719. Yang D, Liang X, Pallas B, Hoenerhoff M, Ren Z, Han R, Zhang J, Chen YE, Jin J-P, Sun F, Xu J. (2021) Production of CFTR-deltaF508 Rabbits Frontiers in Genetics 11: 627666. Xu J, Zhang J, Yang D, Song J, Pallas B, Zhang C, Hu J, Peng X, Christensen N, Han R* and Chen YE*. (2021) Gene editing in rabbits: unique opportunities for translational biomedical research. Frontiers in Genetics 12: 642444. Li H, Zhao L, Lau YS, Zhang C, Han R. (2020) Genome-wide CRISPR screen identifies LGALS2 as an oxidative stress-responsive gene with an inhibitory function on colon tumor growth. Oncogene doi: 10.1038/s41388-020-01523-5. Lau YS, Zhao L, Zhang C, Li H, Han R. (2020) Genetic disruption of the inflammasome adaptor ASC has minimal impact on the pathogenesis of Duchenne muscular dystrophy in mdx Mice. Life Sciences 257: 118069. Sui T, Xu L, Lau YS, Liu D, Liu T, Gao Y, Lai L, Han R, Li Z. (2020) Correction: Development of muscular dystrophy in a CRISPR-engineered mutant rabbit model with frame-disrupting ANO5 mutations. Cell Death Dis doi: 10.1038/s41419-020-2659-x: . Zhang M, Wang B, Urabe G, Ozer G, Han R, Kent C, Guo L. (2020) Angioplasty-induced epigenomic remodeling entails BRD4 and EZH2 hierarchical regulations bioRxiv doi: https://doi.org/10.1101/2020.03.12.989640: . Dwivedi P, Kiran S, Han S, Dwivedi M, Khatik R, Fan R,Mangrio F, Du K, Zhu Z, Yang C, Huang F, Ejaz A, Han R, Si T, Xu R. (2020) Magnetic targeting and ultrasound activation of liposome-microbubble conjugate for enhanced delivery of anti-cancer therapies. ACS Applied Materials & Interfaces 12(21): 23737-23751. Wang P, Xu L, Gao Y and Han R. (2020) BEON: A functional fluorescence reporter for quantification and enrichment of adenine base editing activity. Mol Ther 28(7): 1696-1705. Zhang C, Li H and Han R. (2020) An open-source video tracking system for mouse locomotor activity analysis. BMC Res Notes 13(1): 48. Brown P, RELISH Consortium and Zhou Y. (2019) Large expert-curated database for benchmarking document similarity detection in biomedical literature search. Database doi: 10.1093/database/baz085. Xu L, Liu Y, Han R. (2019) BEAT: A python program to quantify base editing from Sanger sequencing. CRISPR J 2(4): 223-229. Xu L#, Lau YS#, Gao Y#, Li H, Han R. (2019) Life-long AAV-mediated CRISPR genome editing in dystrophic heart improves cardiomyopathy without causing serious lesions in mdx mice. Mol Ther 27: 1407-1414. Lau YS, Xu L, Gao Y, Han R. (2018) Automated muscle histopathology analysis using CellProfiler. Skelet Muscle 8: 32. Sui T, Xu L, Lau YS, Liu D, Liu T, Gao Y, Lai L*, Han R*, Li Z*. (2018) Development of muscular dystrophy in a rabbit model with Ano5 mutations generated by CRISPR/Cas9. Cell Death Dis 9: 609. Xu L, Gao Y, Lau YS, Han R. (2018) Adeno-Associated Virus-Mediated Delivery of CRISPR for Cardiac Gene Editing in Mice. J Vis Exp doi: 10.3791/57560. Sui T, Lau YS, Liu D, Liu T, Xu L, Gao Y, Lai L*, Li Z*, Han R*. (2018) A novel rabbit model of Duchenne muscular dystrophy generated by CRISPR/Cas9. Dis Model Mech 11: dmm032201. Xu J, Xu L, Lau YS, Gao Y, Moore SA, Han R. (2018) A novel ANO5 splicing variant in a LGMD2L patient leads to production of a truncated aggregation-prone Ano5 peptide. J Pathol Clin Res 4: 135-145. El Refaey M, Xu L, Gao Y, Canan BD, Adesanya TMA, Warner SC, Akagi K, Symer DE, Mohler PJ, Ma J, Janssen PML, Han R. (2017) In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice. Circ Res 121: 923-929. Xu L, Zhao L, Gao Y, Xu J, Han R. (2017) Empower multiplex cell and tissue-specific CRISPR-mediated gene manipulation with self-cleaving ribozymes and tRNA. Nucleic Acids Res 45: e28.