Perlmutter, Patrick - Monash University

研究领域

Organic synthesis 1.Total Synthesis. Current targets include: The Pervilleines, the Salvinorins, the Pamaycins, the steroids and the Abietanes. 2.Asymmetric catalysis based on our chiral benzoxazines. 3.New imaging agents based on kangaroo paw pigments. 4.New imaging agents based on cocaine. 5.New auxiliaries for stereocontrolled oxidative coupling reactions. Biological and medicinal chemistry 1.Peptide-based vaccines for cancer. 2.Beta-amino acid derived hybrid peptides as tools in biology. 3.Structured beta-peptide templates for biomineralisation. 4.New, super-stabilised beta-peptides as new materials for nanotechnology.

近期论文

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Peptide based vaccines: from discovery to application. Purcell, A. W.; Dudek, N. L.; Perlmutter, P.; Aguilar, M.-I.; Williamson, N. A. Curr. Op. Mol. Therap., 2009, in press. Catalytic, asymmetric hydrosilylations, Mayes, P. A.; Perlmutter, P. in Modern Reduction Methods(Andersson, P. G.; Munslow, I. eds) Wiley-VCH, 2008. 87-105. a,b-Amino Acid – Derived Hybrid Peptides – new opportunities in Peptidomimetics. Aguilar, M.-I; Purcell, A. W.; Smith, A. I.; Perlmutter, P. Org. & Biomol. Chem., 2007, 5, 2884-2890. b-Amino Acids. Versatile Peptidomimetics. Aguilar, M.-I.; Lew, R. A.; Perlmutter, P.; Smith, A. I.; Steer, D. L. Curr. Med. Chem. 2002, 9, 811-822. Use of b-amino acids in the design of substrate-based peptidase inhibitors. Lew, R. A.; Boulos, E.; Stewart, K. M.; Perlmutter, P.; Harte, M. F.; Bond, S.; Reeve, S. B.; Norman, M. U.; Lew, M. J.; Aguilar, M.-I.; Smith, A. I. Peptides: The Wave of the Future, 2001, 553-554. The total synthesis of 20-norsalvinorin A. 1. Bergman, Y. E.; Mulder, R. J.; Perlmutter, P. J. Org. Chem., 2009, 74, 2589-2591. Surface acoustic waves as an energy source for drop scale organic synthesis. Kulkarni, K.; Friend, J.; Yeo, L. Perlmutter, P. Lab Chip 2009, 9, 754-755. A simple, efficient imine synthesis. Bergman, Y. E.; Thienthong, N.; Perlmutter, P. Synth. Commun.2009, 39, 2683-2693. One-Pot Synthesis of 3,4-Dihydropyrimidine-2-(1H)-ones Using CsF-Celite as Catalyst.Chancharunee, S.; Pinhom, P.; Pohmakotr, M.; Perlmutter, P. Synth. Commun. 2009, 39, 880-886. Microwave-assisted selenium dioxide mediated selective oxidation of 1-tetralones to 1,2-naphthoquinones. Gelman, D. M.; Perlmutter, P. Tetrahedron Lett.2009, 50, 39-40. The enantioselective total synthesis and unambiguous proof of the absolute stereochemistry of pervilleine C. Kulkarni, K.; Zhao, A. Y.; Purcell, A. W.; Perlmutter, P.Synlett 2008, 2209-2212. Large scale synthesis of triacylglycerols containing DHA. Andrews, P. C.; Fraser, B. H.; Junk, P. C.; Massi, M.; Perlmutter, P.; Thienthong, N.; Wijesundera, C.; Tetrahedron2008, 64, 9197-9202. The synthesis of Fmoc-O-allyl beta-serine. Bergman, Y.; Ciampini, M.; Jalal, S.; Lagiakos, H.; Aguilar, M.-I.; Perlmutter, P., Tetrahedron: Asymm. 2008, 19, 2861-2863.