个人简介

Ph.D., Yale University B.S., North Carolina State

研究领域

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Biochemistry/Molecular Biology

Genetic regulatory mechanisms in yeast. George Sprague is no longer active in research but is still active in the Biology Department teaching program. During his research career he used yeast as a model to investigate basic problems in genetics and cell biology. His primary interests were: Transcriptional regulatory mechanisms that determine cell type Mechanisms by which signal transduction pathways are regulated and signaling specificity is maintained Mechanisms by which cell polarity decisions are executed sprague research Localization of Bud4p, a protein required for the axial budding pattern. Bud4p was fused to green fluorescence protein (GFP) and visualized by virtue of the intrinsic fluorescence of GFP. Although the budding pattern of yeast cells changes when they are shifted from glucose rich to glucose limiting conditions, the localization of Bud4p does not change. sprague research The three yeast cell types and the regulatory proteins encoded by the MAT locus are depicted. These proteins, together with Mcm1, which is encoded elsewhere in the genome, govern expression of three sets of genes: a-specific genes, α-specific genes, and a1·α2-repressed genes. Figure taken from: Sprague GF, PNAS 2005;102:959-960. sprague research Three MAPK pathways in yeast share common components and also contain pathway-specific factors.