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个人简介

刘红云,博士,教授,博士生导师,主要研究方向为 泌乳生物学及奶牛泌乳调控 , 聚焦奶牛乳品质形成与乳腺健康,在建立并优化奶牛乳腺泌乳功能研究平台的基础上,阐明了不同生理阶段和不同日粮构成对奶牛泌乳的调节机制并构建泌乳多层次调控网络;揭示了限制性氨基酸(AA)及其小肽促进乳蛋白合成的差异代谢与利用机制;解析了奶牛乳腺应对氧化应激的重要内源性信号通路,解明了热应激影响乳腺泌乳的分子机理,提出了缓解乳腺氧化/热应激的营养策略。 现为国家奶牛产业技术体系泌乳生理与调控岗位科学家、全国草食动物健康生产专业委员会常务理事、全国动物营养指导委员会奶牛分会委员、中国畜牧兽医学会养牛学分会和动物营养学分会理事、浙江省细胞生物学会理事,J. Anim. Physiol. Anim. Nutr. 副主编、Animals编委。 近5年,共主持国家自然科学基金面上项目(×4)、国家重点研发计划子课题(×2)、浙江省杰出青年科学基金等项目近20项;获省部级科技进步和发明创业二等奖各1项(排名均为第二);授权国家发明专利4件,受理1件,转化1件;以通讯作者在J. Dairy Sci.(×4)、J. Nutr.(×2)、Oxidative Med. Cell. Longev.(×2)、Prog. Lipid Res.等杂志发表SCI论文26篇,总IF5=144.5,其中IF5 >5.0 16篇(单篇最高15.323); 在Anim. Nutr.、中国农业科学等国内期刊发表论文8篇。参编《反刍动物营养生理》、《动物分子营养学》等著作和《动物细胞生物学》、《养牛学》等本科生规划教材6部;作为会议主席主办奶畜泌乳生物学国际研讨会1次,担任大型学术研讨会秘书长3次,应邀在国内外学术会议做特邀专家/大会报告16次。 教育与工作经历 2019年12-至今,浙江大学教授 2010年12月-2019年11月,浙江大学副教授 2008年9月-2010年12月,浙江大学讲师 2006年7月至2008年8月,浙江大学师资博士后研究 2001年9月至2006年6月,浙江大学攻读博士学位 1997年9月-2001年6月,山东农业大学动物科技学院攻读学士学位 其中 2011年11月-2012年12月,在美国康奈尔大学营养系从事访问学者研究

研究领域

· 反刍动物营养 · 泌乳生物学与奶牛泌乳调控

近期论文

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2022年 Dai WT, Liu JX, Liu HY*. Organelles coordinate milk production and secretion during lactation: insights into mammary pathology. Progress in Lipid Research. 2022, https://doi.org/10.1016/j.plipres.2022.101159(IF5年=15.323) Xu LB, Zeng J, Wang HN*, Liu HY*. Comparison of diagnostic values of maternal arginine concentration for different pregnancy complications: a systematic review and meta-analysis. Biomedicines 2022, 10, 166. https://doi.org/10.3390/biomedicines10010166 (IF5年=5.718) Li Y, Wang JQ, Mei J, LX Huang*, Liu HY*. Effects of mulberry branch and leaves silage on microbial community, rumen fermentation characteristics, and milk yield in lactating dairy cows. Fermentation. 2022, 8, 86; https://doi.org/10.3390/fermentation8020086(IF年=3.975) Hou PF,Wang CH, Zhou MM*, Liu HY*. Properties and regulation of Gly-Sar uptake and transport in bovine intestinal epithelial cells. Journal of Animal Physiology and Animal Nutrition. 2022,106:24-32(IF5年=2.322) Pengfei Hou, Wenting Dai, Yanshan Jin, Fengqi Zhao, Jianxin Liu, Hongyun Liu, Maternal exposure to di-2-ethylhexyl phthalate (DEHP) depresses lactation capacity in mice, Science of The Total Environment, 2022,837: 155813 (IF5年=7.963) Caihong Wang, Fengqi Zhao, Jianxin Liu, Hongyun Liu, The ubiquitin ligase Nedd4-2 mediates the regulation of PepT2 by mTORC1 in bovine mammary epithelial cells, Animal Nutrition, 2022, 10:12-18 (IF5年=6.383) 2021年 Wang CH, Zhao FQ, Liu JX, Liu HY*.The ubiquitin ligase Nedd4-2 mediates the regulation of PepT2 by mTORC1 in bovine mammary epithelial cells. Animal Nutrition. 2022, https://doi.org/10.1016/j.aninu.2021.11.008. (IF5年=5.497) Zhao MM,Xu LB, Zhao FQ*, Liu HY*. Regulation of milk protein synthesis by free and peptide-bound amino acids in dairy cows. Biology-Basel. 2021, 10, 1044; https://doi.org/10.3390/biology10101044(IF5年=5.079) Li YX, Shao JJ,Hou PF, Zhao FQ, Liu HY*. Nrf2-ARE signaling partially attenuates lipopolysaccharide induced mammary lesions via regulation of oxidative and organelle stresses, but not inflammatory response in mice. Oxidative Medicine and Cellular Longevity. 2021, 8821833, https://doi.org/10.1155/2021/8821833 ( IF5年= 7.454) Lan W, Ren YF, Wang Z, Liu JX, Liu HY*. Metabolic Profile Reveals the Immunosuppressive Mechanisms of Methionyl-Methionine in Lipopolysaccharide-Induced Inflammation in Bovine Mammary Epithelial Cell. Animals. 2021, 11, 833. https://doi.org/10.3390/ani11030833 ( IF =2.942) Li Y, Lv M, Wang JQ, Tian ZH, Yu B, Wang B*, Liu, Liu JX, Liu HY*. Dandelion supplementation enhanced rumen fermentation through the interaction between ruminal microbiome and metabolome. Microorganisms. 2021, 9(1), 83; https://doi.org/10.3390/microorganisms9010083(IF年=4.128) Yao KY, Jiang LY, Liu JX, Wang DM, Liu HY, Ren DX. Effect of yellow wine lees supplementation on milk antioxidant capacity and hematological parameters in lactating cows under heat stress. Animals. 2021, 11: 2643. Gu FF, Miao C, Jiang LY, Wang DM, Liu HY, Liu JX*. Dietary supplementation with N-carbamoylglutamate initiated from the prepartum stage improves lactation performance of postpartum dairy cows. Animal Nutrition. 2021,https://doi.org/10.1016/j.aninu.2020.07.002. 2020年 Lan W, Wang Z, Liu JX, Liu HY*. Methionyl-methionine exerts anti-inflammatory effects through the JAK2-STAT5-NF-κB and MAPK signaling pathways in bovine mammary epithelial cells. Journal of Agricultural and Food Chemistry. 2020, 68 (47):13742-13750(IF5年=5.269) Wang CH, Liu H, Wang C, Liu JX, Liu HY*. Effects of dietary rumen-protected betaine on lactation performance and serum metabolites of mid-lactation Holstein dairy cows. Journal of Agricultural and Food Chemistry. 2020, 68: 13154-13159(IF5年=5.269) Chen Q, Zhao FQ, Ren YF, Han JL, Liu JX, Li Y, Liu HY*. Parenterally delivered methionyl-methionine dipeptide during pregnancy enhances mammogenesis and lactation performance over free methionine by activating PI3K-AKT signaling in methionine-deficient mice. Journal of Nutrition. 2020, https://doi.org/10.1093/jn/nxaa005 ( IF5年= 5.718) Dai WT, Zhao FQ, Liu JX, Liu HY*. ASCT2 is involved in SARS-mediated β‑Casein synthesis of bovine mammary epithelial cells with methionine supply. Journal of Agricultural and Food Chemistry. 2020, 68: 13038-13045, DOI: 10.1021/acs.jafc.9b03833 (IF5年= 5.269) Shi HB, Tai DM, Wang C, Liu JX, Loor JJ, Liu HY*. The antilipogenic effect of trans-10, cis-12 conjugated linoleic acid in bovine mammary epithelial cells is associated with proteasome activity and ATP production. Journal of Dairy Science. 2020, 103: 9096-9101(IF5年= 4.354) Wang CH, Zhao FQ, Liu JX, Liu HY*. The essential role of N-glycosylation in the transport activity of bovine peptide transporter 2. Journal of Dairy Science. 2020, https://doi.org/10.3168/jds.2019-16858(IF5年= 4.354) Dai WT, Zhao FQ, Liu JX, Liu HY*. Seryl-tRNA synthetase is involved in methionine stimulation of β-casein synthesis in bovine mammary epithelial cells. British Journal of Nutrition. 2020,123(5): 489-498(IF5年= 4.816) Yao KY, Wei ZH, Xie YY, Wang DM, Liu HY, Fang D, Ma MR, Liu JX. Lactation performance and nitrogen utilization of dairy cows on diets including unfermented or fermented yellow wine lees mix. Livestock Science. 2020, 236: 104025 (IF5年= 1.905) 2019年 Wang CH, Sun YL, Zhao FQ, Liu JX, Liu HY*. Functional Characterization of Peptide Transporters in Bovine Mammary Epithelial Cells. Journal of Agricultural and Food Chemistry. 2019, 67: 213-219(IF5年= 5.269) Han JL, Shao JJ, Chen Q, Sun HZ, Guan LL, Li YX, LiuJX,Liu HY*. Transcriptional changes in the hypothalamus, pituitary and mammary gland underlying decreased lactation performance in mice under heat stress. FASEB Journal. 2019, doi.org/10.1096/fj.201901045R (IF5年= 5.955) Zou YX, Shao JJ, Li YX, Zhao FQ, Liu JX, Liu HY*. Protective Effects of Inorganic and Organic Selenium on Heat Stress in Bovine Mammary Epithelial Cells. Oxidative Medicine and Cellular Longevity. 2019, https://doi.org/10.1155/2019/1503478 ( IF5年= 7.454) Chen Q, Wang CH, Zhao FQ, LiuJX,Liu HY*. Effects of methionine partially replaced by methionyl-methionine dipeptide on intestinal function in methionine-deficient pregnant mice. Journal of Animal Physiology and Animal Nutrition. 2019,103:1610–1618(IF5年= 2.322) Shi HB, Wang L, Luo J, Liu JX, Juan L*, Liu HY*. Fatty acid elongase 7 (ELOVL7) plays a role in the synthesis of long chain unsaturated fatty acids in goat mammary epithelial cells. Animals. 2019, 9, 389; doi:10.3390/ani9060389 ( IF = 2.942) Wang BB, Wang C, Guan RW, Shi K, Wei ZH, Liu JX, Liu HY*. Effects of Dietary Rumen-Protected Betaine Supplementation on Performance of Postpartum Dairy Cows and Immunity of Newborn Calves. Animals. 2019, 9:167; doi:10.3390/ani9040167 ( IF = 2.942) Xu QB, Liu HY, Zhao FQ, Wu YM, Huang XB, Liu ZX, JX Liu. Mechanism of peptide absorption in the isolated forestomach epithelial cells of dairy cows. Journal of the Science of Food & Agriculture. 2019; 99: 100–108(IF5年= 2.945) 2018年 Chen Q, Dai WT, Sun YL, Zhao FQ, Liu JX, Liu HY*. Methionine partially replaced by methionyl-methionine dipeptide improves reproductive performance over methionine alone in methionine-deficient mice. Nutrients. 2018, 10, 1190; doi:10.3390/nu10091190 (IF5年= 6.349) Lin XJ, Li SS, Zou YX, Zhao FQ, Liu JX, Liu HY*. Lysine stimulates protein synthesis via promoting the expression of ATB0,+ and activating the mTOR pathway in bovine mammary epithelial cells. Journal of Nutrition. 2018, 148:1426–1433 (IF5年= 5.718) Dai WT, White RR, Liu JX, Liu HY*. Seryl-tRNA synthetase-mediated essential amino acids regulate β-casein synthesis via cell proliferation and mammalian target of rapamycin (mTOR) signaling pathway in bovine mammary epithelial cells. Journal of Dairy Science. 2018, 101:1-13(IF5年= 4.354) Wang CH, Zhao FQ, Liu JX, Liu HY*. Dipeptide (methionyl-methionine) transport and its effect on β-casein synthesis in bovine mammary epithelial cells. Cellular Physiology and Biochemistry. Cellular Physiology Biochemistry. 2018,49:479-488 (IF5年=4.354) Dai WT, Wang QJ, Zhao FQ, Liu JX, Liu HY*. Understanding the regulatory mechanisms of milk production using integrative transcriptomic and proteomic analyses: improving inefficient utilization of crop by-products as forage in dairy industry. BMC Genomics. 2018, 19:403 (IF5年= 4.478) Wang CH, Wang C, Liu JX, Liu HY*. Proteomic analysis of the effects of lutein on mammary gland metabolism in dairy cows. Journal of Dairy Research. 2018, 85 :152-156(IF5年= 2.019) Dai WT, YX Zou, White R, Liu JX, Liu HY*. Transcriptomic profiles of the bovine mammary gland during lactation and the dry period. Functional & Integrative Genomics. 2018, 18: 125–140 (IF5年= 3.616) Sun HZ, Wand DM, Liu HY, Liu JX. Metabolomics integrated with transcriptomics reveals a subtle liver metabolic risk in dairy cows fed different crop by-products. Proteomics. 2018, 18:1800122 (IF5年= 3.476) Xu QB, Liu ZX, Liu HY, Zhao FQ, Huang XB1, Wu YM*, Liu JX*. Functional characterization of oligopeptide transporter 1 of dairy cows. Journal of Animal Science and Biotechnology. 2018, 9:7 (IF5年= 4.392) Wang DM, Zhang BX, Wang JK, Liu HY, Liu JX*. Effect of dietary supplements of biotin, intramuscular injections of vitamin B12, or both on postpartum lactation performance in multiparous dairy cows. Journal of Dairy Science. 2018,101:7851-7856 (IF5年=3.432) Wang DM, Zhang BX, Wang JK, Liu HY, Liu JX*. Effects of dietary 5,6-dimethylbenzimidazole supplementation on vitamin B12 supply, lactation performance, and energy balance in dairy cows during the transition period and early lactation. Journal of Dairy Science. 2018, 101:2144–2147. (IF5年=3.432) 2017年 Dai WT, Chen Q, Wang QJ, White R, Liu JX, Liu HY*. Complementary transcriptomic and proteomic analyses reveal regulatory mechanisms of milk protein production in dairy cows consuming different forages. Scientific Reports. 2017, 7:44234 (IF5年= 5.133) Li SS, Wang QJ, Lin XJ, Jin XL, Liu L, Wang CH, Chen Q, Liu JX, Liu HY*. The use of “Omics” in lactation research in dairy cows. International Journal of Molecular Sciences. 2017, 18, 983 (IF5年= 6.132) Sun HZ, Shi K, Wu XH, Xue MY, Wei ZH, Liu JX, Liu HY*. Lactation-related metabolic mechanism investigated based on mammary gland metabolomics and 4 biofluids’ metabolomics relationships in dairy cows. BMC Genomics. 2017, 18: 936-950 (IF5年= 4.478) Dai WT, Wang QJ, Zou YX, White R, Liu JX, Liu HY*. Comparative proteomic analysis of the lactating and non-lactating bovine mammary gland. Journal of Dairy Science. 2017,100:5928–5935(IF5年= 4.354) Zhang B, Liu H, Liu JX, Liu HY*. Effects of dietary protein level on growth performance and nitrogen excretion of dairy heifers. Asian-Australasian Journal of Animal Sciences. 2017,30:386-391(IF5年= 2.604) Li SS, Loor JJ*, Liu HY, Liu L, Hosseini A, Zhao WS, Liu JX*. Optimal ratios of essential amino acids stimulate β-casein synthesis via activation of the mammalian target of rapamycin signaling pathway in MAC-T cells and bovine mammary tissue explants. Journal of Dairy Science. 2017, 100(8):6676-6688 (IF5年=3.432) 2016年 Jin XL, Wang K, Liu HY*, Hu FL, Zhao FQ, Liu JX*. Protection of bovine mammary epithelial cells from hydrogen peroxide-induced oxidative cell damage by resveratrol. Oxidative Medicine and Cellular Longevity. 2016, 4: 1-15 ( IF5年=5.608) Wang CH, Zhao FQ, Liu JX, Liu HY*. Peptide transport and metabolism by the lactating mammary gland reply. Journal of Nutrition. 2016, 146: 384-385. ( IF5年= 5.075) Jin XL, Wang K, Liu L, Liu HY*, Zhao FQ, Liu JX*. Nuclear factor-like factor 2-antioxidant response element signaling activation by tert-butylhydroquinone attenuates acute heat stress in bovine mammary epithelial cells. Journal of Dairy Science. 2016, 99:1-10 (IF5年=3.432) Zhang B, Wang C, Wei ZH, Sun HZ, Xu GZ, Liu J, Liu HY*. The effects of dietary phosphorus on the growth performance and phosphorus excretion of dairy heifers. Asian-Australasian Journal of Animal Sciences. 2016, 29(7):960-964. (IF5年=1.907) Sun HZ, Wang B, Wang JK, Liu HY, Liu JX*. Biomarker and Pathway Analyses of Urine Metabolomics in Dairy Cows when Corn Stover Replaces Alfalfa Hay. Journal of Animal Science and Biotechnology. 2016, 7:49 (IF5年=4.392) 2015年 Yang JX, Wang CH, Xu QB, Zhao FQ, Liu JX, Liu HY*. Methionyl-methionine promotes α-s1 casein synthesis in bovine mammary gland explants by enhanceing intracellular substrate availability and activating JAK2-STAT5 and mTOR mediated signaling pathways. Journal of Nutrition. 2015, 145: 1748-1753 (IF5年= 5.075) Liu HY, Zhu WZ, Lu BY, Wei ZH, Ren DX*. Effect of feed selenium supplementation on milk selenium distribution and mozzarella quality. Journal of Dairy Science. 2015, 98 1-9 (IF5年=3.432) Jin XL, Wei ZH, Liu L, Liu HY*, Liu JX*. Comparative studies of two methods for miRNA isolation from milk whey. Journal of Zhejiang University Science-B. 2015, 16: 533-540 (IF5年=2.054) Wang DM, Chacher B, Liu HY, Wang JK, Lin J, Liu JX*. Effects of γ- aminobutyric acid on feed intake, growth performance and expression of related genes in growing lambs. Animal. 2015, 9: 445-448 (IF5年=2.571) Sun HZ, Wang DM, Wang B, Wang JK*, Liu HY, Guan LL, Liu JX*. Metabolomics of Four Biofluids from Dairy Cows: Potential Biomarkers for Milk Production and Quality. Journal of Proteome Research. 2015, 14 (2): 1287–1298 (IF5年=3.946) 中文代表性论文 任怡飞, 刘建新, 刘红云*. 自噬对奶牛乳腺发育和功能影响的研究进展. 中国畜牧杂志. 2019,55(9):11-17 李泳欣, 邹艺轩, 刘建新, 刘红云*. 奶牛氧化应激及天然植物抗氧化提取物研究进展. 浙江大学学报(农业与生命科学版)2018, 44(5):549-554 韩佳良, 刘建新, 刘红云*. 热应激对奶牛泌乳性能的影响及其机制. 中国农业科学. 2018,51(16):3162-3170 张彬,刘赫,释凯,王翀,刘建新, 刘红云*. 荷斯坦奶牛首次产犊月龄对其头胎产奶量的影响调查. 中国畜牧杂志, 2018,54 (1):131-133 叶艇, 曹志军, 李胜利, 刘建新, 刘红云*. 基于“牛精英”项目的畜牧学科研究生教育改革探索. 中国校外教育. 2017, 10: 118-120 王贝贝, 释凯, 刘建新, 刘红云*. 干奶期热应激对奶牛新生犊牛机体健康及头胎母牛繁殖与产奶性能的影响. 中国畜牧杂志. 2017,53(9): 8-11 张彬, 阿明古丽·牙生, 孟秀荣, 曹志军, 李胜利, 刘建新, 刘红云*. 强化饲喂对哺乳犊牛生长性能影响的调查研究. 中国畜牧杂志. 2016, 52(10):34-37 刘兰, 刘红云*, 刘建新. 奶牛乳腺氨基酸代谢利用及其信号通路. 动物营养学报. 2016, 28(2): 345-352 释凯,李勇,任大喜,刘建新, 刘红云*. 有机硒对奶牛生产性能的影响及富硒乳制品开发研究.中国畜牧杂志. 2015,51(24):44-48

学术兼职

现为国家奶牛产业技术体系泌乳生理与调控岗位科学家、全国草食动物健康生产专业委员会常务理事、全国动物营养指导委员会奶牛分会委员、中国畜牧兽医学会养牛学分会和动物营养学分会理事、浙江省细胞生物学会理事,J. Anim. Physiol. Anim. Nutr. 副主编、Animals编委。

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