Pyke, Simon - University of Adelaide - Department of Chemistry

研究领域

Medicinal chemistry of small bioactive molecules and their interactions with protein targets Bio-organic chemistry & molecular toxicology of highly reactive aldehydes Application of NMR spectroscopy for the determination of molecular structure, conformation and dynamics of small organic molecules and protein-small molecule complexes Natural products chemistry.

近期论文

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66. "Student perceptions of chemistry experiments with different technological interfaces: A comparative study" S. Priest, N. M. Williamson and S. M. Pyke, J. Chem. Educ., 2014, 91, 1787-1795. 65. "Development of POGIL-style classroom activities for an introductory chemistry course" N. M. Williamson, G. F. Metha, J. Willison and S. M. Pyke, Internat. J. Innov. Sci. Maths. Educ., 2013, 21, 27-41. 64. "Learning to lead change: SaMnet's action-learning projects" W. Rifkin, M. Sharma, A. Crampton, B. Yates, K. Matthews, S. Beames, C. Varsavsky, E. Johnson, S. Jones and S. M. Pyke, Aust. J. Educ. Chem., 2012, 72, 9-16. 63. “The iPad guarantee: information literacy, the library and a reinvigorated undergraduate science program” U. Henderson and S. M. Pyke in VALA2012 Conference Proceedings (available from http://www.vala.org.au/vala2012-proceedings/vala2012-session-4-henderson). 62. “The Advancing Science by Enhancing Learning in the Laboratory (ASELL) Project: The Next Chapter” A. Yeung, S. M. Pyke, S. H. Kable, M. D. Sharma, S. C. Barrie, M. A. Buntine, K. Burke da Silva and K. F. Lim, Internat. J. Innov. Sci. Maths. Educ., 2011, 19(2), 51-72. 61. “Isolation, structural elucidation and in vivo activity of four new benzoyl ester clerodane diterpenoid derivatives from Dodonaea polyandra” B. S. Simpson, D. J. Claudie, J. P. Gerber, S. M. Pyke, J. Wang, R. A. McKinnon and S. J. Semple. J. Nat. Prod., 2011, 74, 650-657. 60. “The Development of Teaching Skills to Support Active Learning in University Science (ALIUS)” D. R. Bedgood, A. Bridgeman, M. A. Buntine, K. F. Lim, M. Gardiner, B. Yates, G. Morris, S. M. Pyke and M. Zadnik, J. Learning Design, 2010, 3(3), 10-19. 59. “The Advancing Science by Enhancing Learning in the Laboratory (ASELL) Project: The Next Chapter” S. M. Pyke, A. Yeung, S. H. Kable, M. D. Sharma, S. C. Barrie, M. A. Buntine, K. Burke da Silva and K. F. Lim in Proceedings of the 16th UniServe Science Annual Conference, Sydney, NSW, 2010. 58. “Improving student engagement in the laboratory: An initiative across all Australian universities”S. C. Barrie, M. A. Buntine, K. Burke da Silva, K. F. Lim, S. M. Pyke, M. D. Sharma, A. Yeung and S. H. Kable, 2010. Abstracts of Papers, 240th ACS National Meeting, Boston, MA, United States. 57. “The synthesis, characterization and structures of some 4-[((E)-1-{2-hydroxy-5-[(E)-2-(aryl)-1-diazenyl]phenyl}methylidene)amino]benzoic acids” Tushar S. Basu Baul , Pradip Das, Asit K. Chandra, Sivprasad Mitra, Simon M. Pyke, Dyes Pigm., 2009, 82, 379-396. 56. “Sequential and selective Buchwald-Hartwig amination reactions for the controlled functionalization of 6-bromo-2-chloroquinoline: Synthesis of ligands for the Tec Src homology 3 domain” Jessica A. Smith, Rhiannon K. Jones, Grant W. Booker and Simon M. Pyke, J. Org. Chem., 2008, 73, 8880-8892. 55.“Synthesis and cyclisations to aurones and flavones, of alkoxy-substituted aryl, arylalkynylketones”P. J. Kerr, S. M. Pyke and A. D. Ward, Aust. J. Chem., 2008, 61, 350-358. 54.“Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury” P. C. Burcham, L. M. Kaminskas, D. Tan, and S. M. Pyke, Mini Rev. Med. Chem., 2008, 8, 319-330. 53.“Antimicrobial compounds from Eremophila serrulata” C. P. Ndi, S. J. Semple, H. J. Griesser, S. M. Pyke and M. D. Barton, Phytochemistry, 2007, 68, 2684-2690. 52. “Antimicrobial compounds from the Australian desert plant Eremophila neglecta”Chi P. Ndi, S. J. Semple, H. J. Griesser, S. M. Pyke and M. D. Barton. J. Nat. Prod., 2007, 70, 1439-1443. 51.“Michael addition of acrolein to lysinyl and N-terminal residues of a model peptide: Targets for cytoprotective hydrazino drugs”, L. M. Kaminskas, S. M. Pyke & P. C. Burcham, Rapid Commun. Mass Spec., 2007, 21, 1155-1164.