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个人简介

学习经历 1991.09-1995.06 (原)北京农业大学 微生物系 本科生 1997.09-2002.06 中国农业大学 生物化学与分子生物学系 研究生 工作经历 1995.07-1997.08 黑龙江省微生物研究所 科员 2002.07-2004.06 中国农业大学 植物病理专业 博士后 2004.07-2005.12 中国农业大学 动物科技学院 助理研究员 2013.12-2014.11 美国科罗拉多大学(丹佛)访问学者 2006.01-2021.12 中国农业大学 动物科技学院 副研究员 2022.01-现在 中国农业大学 动物科技学院 教授 获得奖励与荣誉 猪健康养殖的营养调控技术研究与示范推广,国家科技进步二等奖,2008年,排名第6 畜禽饲料中大豆蛋白源抗营养因子研究与应用,国家科技进步二等奖,2015年,排名第8 仔猪抗病促生长用饲用酶制剂的创制和应用,天津市科技进步二等奖,2015年,排名第2 猪精准营养配方技术体系的建立与应用,神农中华农业科技奖科学研究类成果一等奖,2018-2019年度,排名第6 大豆蛋白饲料预消化技术研究与应用,辽宁农业科技贡献奖一等奖,2020年,排名第2

研究领域

生物饲料添加剂

近期论文

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Yajing Liu, Jian Wang, Chengling Bao, Bing Dong, Yunhe Cao*. Characterization of a novel GH10 xylanase with a carbohydrate binding module from Aspergillus sulphureus and its synergistic hydrolysis activity with cellulose, International Journal of Biological Macromolecules, 2021,182: 701–711. Ting Miao, Abdul Basit, Jiaqi Wen, Junquan Liu, Fengzhen Zheng, Yunhe Cao*, Wei Jiang*. High efficient degradation of glucan/glucomannan to cello-/mannan-oligosaccharide by endoglucanase via tetrasaccharide as intermediate. Food Chemistry, 2021, 350: 129175. Chengling Bao, Suozhu Liu, Zhenda Shang, Yajing Liu, Jian Wang, Wenxiu Zhang, Bing Dong, Yunhe Cao*. Bacillus amyloliquefaciens TL106 protects mice against enterohemorrhagic Escherichia coli O157:H7 induced intestinal disease through improving immune response, intestinal barrier function and gut microbiota. Journal of Applied Microbiology, 2020,131: 470–484. Wenxiu Zhang, Chengling Bao, Jian Wang, Jianjun Zang, Yunhe Cao*. Administration of Saccharomyces boulardii mafic-1701 improves feed conversion ratio, promotes antioxidant capacity, alleviates intestinal inflammation and modulates gut microbiota in weaned piglets. Journal of Animal Science and Biotechnology, 2020, 11:112. Jian Wang, Xu Yang, Yongzhi Yang, Yajing Liu, Xiangshu Piao, Yunhe Cao*. Characterization of a protease-resistant α-galactosidase from Aspergillus oryzae YZ1 and its application in hydrolysis of raffinose family oligosaccharides from soymilk, International Journal of Biology Macromolecules, 2020,158: 708–720. Yongzhi Yang, Jian Wang, Henan Guo, Yunhe Cao*. The enzymatic characters of heterologous expressed novel β-1, 4-glucosidase originated from Aspergillus freseni, 3 Biotech, 2020,10: 239. Fengzhen Zheng, Lina Song, Abdul Basit, Junquan Liu, Ting Miao, Jiaqi Wen, Yunhe Cao*, Wei Jiang*. An endoxylanase rapidly hydrolyzes xylan into major product xylobiose via transglycosylation of xylose to xylotriose or xylotetraose, Carbohydrate Polymers, 2020, 237: 116121. Jian Wang, Yajing Liu,Yongzhi Yang,Chengling Bao,Yunhe Cao*. High level expression of an acidic thermostable xylanase in Pichia pastoris and its application in weaned piglets. Journal of Animal Science, 2020, 98(1):1–10. Jian Wang, Yajing Liu, Xiaojing Guo, Bing Dong, Yunhe Cao*. High-level Expression of Lipase from Galactomyces geotrichum Mafic-0601 by Codon Optimization in Pichia pastoris and its application in hydrolysis of various oils, 3 Biotech, 2019, 9:354. Junquan Liu, Abdul Basit, Ting Miao, Fengzhen Zheng, Hang Yu, Yan Wang, Wei Jiang*, Yunhe Cao*. Secretory expression of β-mannanase in Saccharomyces cerevisiae and its high efficiency for hydrolysis of mannans to mannooligosaccharides, Applied Microbiology and Biotechnology, 2018,102: 10027–10041. Bing Dong, Shaoshuai Liu, Chunlin Wang, Yunhe Cao*. Effects of xylanase supplementation to wheat-based diets on growth performance, nutrient digestibility and gut microbes in weanling pigs. Asian-Australasian Journal of Animal Sciences, 2018, 31(9): 1491–1499. Wenhan Yang, Yongzhi Yang, Lingdi Zhang, Hang Xu, Xiaojing Guo, Xu Yang, Bing Dong, Yunhe Cao*. Improved thermostability of an acidic xylanase from Aspergillus sulphureus by combined disulphide bridge introduction and proline residue substitution. Scientific Reports, 2017, 7: 1587. Honglei Pei, Xiaojing Guo, Wenhan Yang, Junnan Lv, Yiqun Chen and Yunhe Cao*. Directed evolution of a b-1,3-1,4-glucanase from Bacillus subtilis MA139 for improving thermal stability other characteristics. Journal of Basic Microbiology, 2015, 55: 869–878. Wei Fang, He Gao, Yunhe Cao*. Anshan Shan*. Cloning and expression of a xylanase xynB from Aspergillus niger IA-001 in Pichia pastoris. Journal of Basic Microbiology, 2014, 54(S1): S190–S199. Junnan Lv, Yiqun Chen, Honglei Pei, Wenhan Yang, Zhimin Li, Bing Dong*, Yunhe Cao*. Cloning, Expression, and Characterization of β-mannanase from Bacillus subtilis MAFIC-S11 in Pichia pastoris. Applied Biochemistry and Biotechnology, 2013,169: 2326–2340. Yunhe Cao, Defa Li*. Impact of increased demand for animal protein products in asian countries: Implications on global food security,Animal Frontiers, 2013, 3: 49–55. Yiqun Chen,Bo Zhang,Honglei Pei,Junnan Lv,Wenhan Yang,Yunhe Cao*,Bing Dong*. Directed Evolution of Penicillium janczewskii zalesk α-Galactosidase Toward Enhanced Activity and Expression in Pichia pastoris,Applied Biochemistry and Biotechnology, 2012,168: 638–650. Yihang Li, Xiang Chen, Yiqun Chen, Zhimin Li, Yunhe Cao*. Effects of β-Mannanase Expressed by Pichia pastoris in Corn-Soybean Meal Diets on Broiler Performance, Nutrient Digestibility, Energy Utilization and Immunoglobulin Levels,Animal Feed Science and Technology, 2010, 159: 59–67. Yihang Li,Bo Zhang,Xiang Chen,Yiqun Chen,Yunhe Cao*. Improvement of Aspergillus sulphureus endo-β-1,4-xylanase expression in Pichia pastoris by codon optimization and analysis of the enzymic characterization,Applied Biochemistry and Biotechnology, 2010,160: 1321–1331. Wenqing Lu,Chunlin Wang, Ruiguo Li, Yunhe Cao*. In vitro evaluation of feed enzyme compound produced by Aspergillus sulphureus in solid-state fermentation. Journal of Animal Science and Biotechnology, 2010, 1(1): 54–58. Jiayun Qiao, Bing Dong, Yihang Li, Bo Zhang, Yunhe Cao*. Cloning of a β-1,3-1,4-glucanase gene from Bacillus subtilis MA139 and its functional expression in Escherichia coli, Applied Biochemistry and Biotechnology, 2009, 152: 334–342. Yunhe Cao, Jiayun Qiao,Yihang Li,Wenqing Lu*. De novo synthesis, constitutive expression of Aspergillus sulphureus β-xylanase gene in Pichia pastoris and partial enzymic characterization, Applied Microbiology and Biotechnology, 2007,76: 579–585. 郭昱含,杨勇智,郭贺楠,王剑,曹云鹤*. 米曲霉来源α-半乳糖苷酶基因galA在毕赤酵母中的表达及其对豆浆中大豆寡糖的酶解效果, 动物营养学报,2018, 30(11): 4569–4579. 陈轶群,杨雯涵,郭晓晶,韩帅娟,杨勇智,曹云鹤*. α-半乳糖苷酶对生长猪生长性能及营养物质体内外消化率的影响,中国畜牧杂志,2015,51(11): 38–43. 杨雯涵,郭晓晶,陈轶群,吕俊楠,谢飞,曹云鹤*. 一种酸性木聚糖酶在毕赤酵母中的分泌表达及体外活性评价研究,中国农业科技导报,2013,15(5): 59–66. 马威,沈志娜,陈轶群,李志民,曹云鹤*. 枯草芽孢杆菌β-甘露聚糖酶在毕赤酵母中的分泌表达,生物技术通讯,2010,21(2): 247–250. 张波,陈轶群,李志民,李一航,曹云鹤*. 扬奇青霉α-半乳糖苷酶基因agl1在大肠杆菌中的表达与纯化研究, 中国畜牧杂志,2009,45(23): 57–60. 邓萍,曹云鹤*,陆文清,郭小华. 黑曲霉木聚糖酶基因xynB的克隆及其在大肠杆菌中的高效表达,农业生物技术学报,2006,14(5):774–778. 曹云鹤,陈小玲,贺平丽,陆文清*. 硫色曲霉木聚糖酶基因xynA的克隆、表达及酶学性质分析,生物技术通讯,2006,17(6): 878–881. 姜伟、曹云鹤 主编,普通高等教育“十二五”规划教材《发酵工程实验教程》(科学出版社,2014年6月第一次印刷) 主编著作 普通高等教育“十二五”规划教材《发酵工程实验教程》(科学出版社,2014年6月第一次印刷,姜伟、曹云鹤 主编)

学术兼职

北京畜牧兽医学会第十一届理事会理事 国家饲料标委会微生物与酶制剂工作组委员 西藏农牧学院第3批柔性引进人才及校外兼职导师

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